Northwestern University Clinical and Translational Science Institute (NUCATS)

西北大学临床与转化科学研究所 (NUCATS)

• 批准号: 10653872
• 负责人: Richard D'Aquila
• 金额: $ 396.83万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-12 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10653872
• 关键词: Acceleration; Achievement; Address; Adopted; Adult; Analgesics; Applied Research; Area; Arts; Automobile Driving; Biomedical Research; Biometry; Biotechnology; Businesses; Cancer Center; Cardiology; Caring; Chemistry; Chicago; Child; Child Health; Childhood; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Community Physician; Comprehensive Cancer Center; Data Science; Dermatology; Development; Diagnostic; Ecosystem; Education; Engineering; Environment; Evaluation; Evolution; Fostering; Funding; Future; Goals; Health; Healthcare; High Density Lipoproteins; Hospitals; Housing; Human; Hypersensitivity; Immunology; Individual; Industrialization; Informatics; Information Technology; Infrastructure; Institution; Institutional Policy; Institutional Review Boards; Intensive Care; Interdisciplinary Study; Lead; Learning; Letters; Location; Longevity; Lymphoma; Marketing; Maternal-fetal medicine; Medical Device; Medicine; Methods; Mission; Nanotechnology; Neurology; Neurosurgical Procedures; Nursing Faculty; Office Management; Patient Outcomes Assessments; Patients; Pediatric Hospitals; Pharmacology; Physical Medicine; Physical Rehabilitation; Physiology; Population; Population Sciences; Preventive Medicine; Process; Public Health; Rehabilitation therapy; Reporting; Reproducibility; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Role; Schools; Science; Speed; Surveys; System; Testing; Therapeutic; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Universities; Urology; Vision; Work; arm; cancer clinical trial; care systems; clinical care; clinical encounter; clinical practice; college; commercialization; design; digital; drug development; empowerment; experimental study; health care delivery; improved; innovation; materials science; medical schools; nanobiosensor; news; novel; outreach; particle; precision medicine; programs; research study; therapeutic development; tool; undergraduate student

Contact PD/PI: LLOYD-JONES, DONALD M ABSTRACT. The Northwestern University Clinical and Translational Sciences Institute (NUCATS) serves as an integrated hub to advance Clinical and Translational Science (CTS) at three distinct scales: locally, at Northwestern University (NU) and our 3 nationally-renowned clinical partners; regionally, across Chicago and in collaboration with the other two Chicago CTSA hubs and our many community stakeholder partners; and, nationally, through our active participation in the CTSA Consortium. By leveraging continuous CTSA funding since 2008, as well as substantial financial and in-kind support from NU and our partners, NUCATS has succeeded at all three scales, evolving into a mature, balanced, highly-functioning CTSA with a broad portfolio of leading-edge programs spanning T0 through T4. Looking to the future, we recognize that there continue to be exciting strategic opportunities for innovation and improvement, and NUCATS is not afraid to experiment upon itself to achieve our mission of speeding transformative research discoveries to patients and the population, in order to improve human health. We will build on this legacy through five broad-based Global Objectives, which focus on: expanding and further integrating research into clinical care systems and processes, with the ultimate goal that every clinical encounter can be an opportunity for research participation, precision medicine, and learning to improve human health for all; accelerating local, regional, and national CTS by enhancing our existing integrated digital research infrastructure to develop and apply new, leading-edge informatics and data science tools to catalyze research, education, collaboration, engagement, evaluation, and dissemination; broadening our community and stakeholder engagement and advance team science to enable high-functioning, stakeholder-engaged, multi-disciplinary research teams that have impact across the spectrum of CTS; developing, demonstrating, disseminating, and adopting innovative and sustainable CTS methods and processes to accelerate translation and foster a culture of rigor, reproducibility, evaluation, and continuous improvement across the CTSA consortium; and innovating, testing, and disseminating novel training programs to cultivate, equip, and empower the diverse translational research workforce of tomorrow. We propose to leverage CTSA funding to address key strategic opportunities and critical barriers to CTS, not only at NUCATS, but across Chicagoland and the CTSA consortium. In doing so, we anticipate that NUCATS will continue be a central player in the ongoing evolution of the role of CTSA Program in accelerating CTS to improve human health. Page 236 Project Summary/Abstract Contact PD/PI: LLOYD-JONES, DONALD M

联系人 PD/PI：LLOYD-JONES, DONALD M 抽象的。西北大学临床与转化科学研究所 (NUCATS) 一个综合中心，在三个不同的层面上推进临床和转化科学（CTS）：本地、在 西北大学 (NU) 和我们的 3 个全国知名临床合作伙伴；在区域范围内，横跨芝加哥和 与另外两个芝加哥 CTSA 中心以及我们众多社区利益相关者合作伙伴合作；和， 通过我们积极参与 CTSA 联盟，在全国范围内实现这一目标。通过利用持续的 CTSA 资金 自 2008 年以来，以及来自 NU 和我们的合作伙伴的大量财政和实物支持，NUCATS 已 在所有三个层面都取得了成功，发展成为一个成熟、平衡、功能强大、拥有广泛产品组合的 CTSA 涵盖 T0 到 T4 的前沿项目。展望未来，我们认识到，仍然存在 是令人兴奋的创新和改进的战略机遇，NUCATS 不害怕尝试 实现我们的使命，即加速为患者和患者带来变革性的研究发现 人口，以改善人类健康。我们将通过五个基础广泛的全球项目来继承这一传统 目标，重点是：扩大和进一步整合研究到临床护理系统和 过程，最终目标是每次临床遭遇都可以成为参与研究的机会， 精准医疗和学习以改善所有人的健康；加速地方、区域和国家 CTS 通过增强我们现有的综合数字研究基础设施来开发和应用新的、前沿的 信息学和数据科学工具，以促进研究、教育、协作、参与、评估和 传播；扩大我们的社区和利益相关者的参与并推进团队科学，以实现 高效、利益相关者参与、跨学科的研究团队，在整个领域具有影响力 CTS 频谱；开发、展示、传播和采用创新且可持续的 CTS 加速翻译并培育严谨性、可重复性、评估和文化的方法和流程 CTSA 联盟的持续改进；创新、测试和传播新颖的 旨在培养、装备和增强未来多元化转化研究队伍的培训计划。 我们建议利用 CTSA 资金来解决 CTS 的关键战略机遇和关键障碍，而不是 仅限 NUCATS，但横跨芝加哥和 CTSA 联盟。在此过程中，我们预计 NUCATS 将继续成为 CTSA 计划在加速 CTS 发展过程中的核心角色 改善人类健康。 第236页 项目概要/摘要 联系人 PD/PI：LLOYD-JONES, DONALD M

项目成果

Examining minority stress, dyadic coping, and internalizing symptoms among male same-sex couples using actor-partner interdependence models.

使用演员-伴侣相互依赖模型检查男性同性伴侣中的少数群体压力、二元应对和内化症状。

• 发表时间: 2021-10
• 影响因子: 3.9
• 作者: Sarno, Elissa L;Bundy, Camille;Dyar, Christina;Newcomb, Michael E
• 通讯作者: Newcomb, Michael E

Myoelectric interface training enables targeted reduction in abnormal muscle co-activation.

肌电接口训练可以有针对性地减少异常肌肉协同激活。

• 发表时间: 2022-07-01
• 作者: Seo, Gang;Kishta, Ameen;Mugler, Emily;Slutzky, Marc W;Roh, Jinsook
• 通讯作者: Roh, Jinsook

A spotlight on avoidance coping to manage fear of recurrence among breast cancer survivors in an eHealth intervention.

重点关注电子健康干预中乳腺癌幸存者通过回避应对来应对复发的恐惧。

• 发表时间: 2022-10
• 影响因子: 3.1
• 作者: Hall, Daniel L;Levine, Beverly J;Jeter, Elizabeth;Chandler, Allison;Tooze, Janet A;Duffecy, Jenna;Victorson, David;Gradishar, William;Leach, Joseph;Saphner, Thomas;Smith, Mary Lou;Penedo, Frank;Mohr, David C;Cella, David;Wagner, Lynne I
• 通讯作者: Wagner, Lynne I

Implementation Barriers and Experiences of Eligible Patients Who Failed to Enroll in Collaborative Care for Depression and Anxiety.

未能参加抑郁和焦虑协作护理的合格患者的实施障碍和经历。

• 发表时间: 2023-02
• 影响因子: 5.7
• 作者: Fu, Emily;Carroll, Allison J;Rosenthal, Lisa J;Rado, Jeffrey;Burnett;Jordan, Neil;Carlo, Andrew D;Ekwonu, Adaora;Kust, Ariella;Brown, C Hendricks;Csernansky, John G;Smith, Justin D
• 通讯作者: Smith, Justin D

Pathogenic variants in arteriopathy genes detected in a targeted sequencing study: Penetrance and 1-year outcomes after return of results.

靶向测序研究中检测到的动脉病基因的致病变异：外显率和结果返回后的一年结果。

• 发表时间: 2022-10
• 作者: Sherafati, Alborz;Elsekaily, Omar;Saadatagah, Seyedmohammad;Kochan, David C;Lee, Christopher;Wiesner, Georgia L;Liu, Cong;Dellefave;Namjou, Bahram;Perez, Emma F;Salvati, Zachary M;Connolly, John J;Hakonarson, Hakon;Williams, Ma
• 通讯作者: Williams, Ma