Admin Core

管理核心

基本信息

批准号：
10909442
负责人：
ANGELA L. JEFFERSON
金额：
$ 31.04万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10909442
关键词：
Academic Medical Centers Advisory Committees Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease therapeutic Alzheimer&apos s disease therapy Basic Science Biological Markers Clinical Clinical Research Clinical and Translational Science Awards Collaborations Data Development Discipline Disease Pathway Educational workshop Ensure Evaluation Event Faculty Fostering Funding Future Genetic Goals Grant Growth Health Historically Black Colleges and Universities Individual Infrastructure Injury Institution Investigator-Initiated Research Leadership Link Memory Mission Multi-Institutional Clinical Trial National Institute on Aging Outcome Participant Pathway interactions Policies Positioning Attribute Principal Investigator Protocols documentation Research Research Activity Research Institute Research Personnel Research Training Resource Sharing Resources Science Scientist Site Strategic Planning Structure Techniques Training Activity Translational Research Universities career cohort cooperative study data exchange data management data sharing data storage site early-career faculty graduate student health equity improved medical schools medical specialties meetings neuroimaging next generation novel operation pharmacologic programs repository sharing platform training opportunity undergraduate student vascular contributions

项目摘要

PROJECT SUMMARY – ADMINISTRATIVE CORE The Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) Administrative Core is central to achieving the overall mission of the VADRC and will leverage strong institutional resources to provide excellent administrative oversight for a scalable infrastructure to position Vanderbilt University Medical Center and Vanderbilt University for a future successful P30 application. Under the proven leadership of Dr. Angela Jefferson, supported by Associate Directors, Dr. Consuelo Wilkins and Dr. Charles Sanders, the Administrative Core is uniquely positioned to achieve this goal. Our interdisciplinary Core leadership will ensure that all programmatic objectives of the VADRC are accomplished by coordinating and integrating VADRC Cores and scaling these Center functions into a thriving P30-funded ADRC. Core leadership will drive the Center’s scientific direction emphasizing non-amyloid pathways of injury, including understanding vascular contributions to Alzheimer’s disease and related dementias, discovering novel disease pathways using advanced techniques, and improving pharmacological therapies for Alzheimer’s disease and related dementias. The Administrative Core will serve as the institutional hub for all local Alzheimer’s disease research activities by providing strategic planning, scientific direction, campus-wide integration, and essential infrastructure. Core leadership will identify opportunities for growth while harnessing strengths of existing programs. The Administrative Core will establish and facilitate administrative structure, Center governance, and oversight for Center operations. These functions include managing budgetary oversight, ensuring compliance with regulatory requirements, facilitating ongoing internal and external review and evaluation of VADRC activities, and coordinating fiscal, operational, and regulatory functions to ensure effective utilization of Center resources. The Administrative Core will actively support local research activities and contribute to collaborative national research initiatives and resource sharing to advance the goals of the National Alzheimer’s Project Act. Leadership will establish a scalable data sharing platform to support a future P30 Data Management and Statistical Core. Such infrastructure will promote coordinating and integrating VADRC activities for data transfer that serve local investigator needs and support national research efforts (e.g., National Alzheimer’s Coordinating Center, National Centralized Repository for Alzheimer’s Disease and Related Dementias). Additionally, the Administrative Core will support VADRC participation in multi-site clinical trials. Finally, the Core will be integral in fostering professional development of the next generation of clinicians and scientists in Alzheimer’s disease. Collectively, the VADRC Administrative Core will be instrumental in establishing and facilitating harmonized integration between all Center investigators, collaborators, Core functions, institutional resources, and national partners, which will facilitate a smooth transition to a future P30-funded VADRC.

项目摘要——行政核心探索性范德比尔特阿尔茨海默病研究中心 (VADRC) 行政核心是实现 VADRC 的总体使命，并将利用强大的机构资源，提供优秀的对可扩展基础设施的行政监督，以定位范德比尔特大学医学中心和在安吉拉博士的可靠领导下，范德比尔特大学未来将成功申请 P30。杰斐逊在副主任康苏埃洛·威尔金斯 (Consuelo Wilkins) 博士和查尔斯·桑德斯 (Charles Sanders) 博士的支持下，行政 Core 具有实现这一目标的独特优势，我们的跨学科 Core 领导力将确保所有人都能实现这一目标。 VADRC 的计划目标是通过协调和整合 VADRC 核心和将这些中心职能扩展为 P30 资助的蓬勃发展的 ADRC 核心领导层将推动该中心的发展。强调非淀粉样蛋白损伤途径的科学方向，包括了解血管的贡献阿尔茨海默病和相关痴呆症，利用先进技术发现新的疾病途径技术，并改进阿尔茨海默病和相关痴呆症的药物治疗。行政核心将作为所有当地阿尔茨海默病研究活动的机构中心提供战略规划、科学方向、校园范围内的整合和必要的核心基础设施。领导层将发现增长机会，同时利用现有计划的优势。行政核心将建立并促进行政结构、中心治理和监督这些职能包括管理预算监督、确保遵守规定。监管要求，促进对 VADRC 活动进行持续的内部和外部审查和评估，协调财政、运营和监管职能，以确保中心资源的有效利用。行政核心将积极支持当地的研究活动，并为国家合作做出贡献研究计划和资源共享，以推进《国家阿尔茨海默病项目法案》的目标。领导层将建立一个可扩展的数据共享平台，以支持未来的 P30 数据管理和统计核心。此类基础设施将促进 VADRC 数据活动的协调和整合。满足当地研究人员需求并支持国家研究工作（例如国家阿尔茨海默病协调中心，国家阿尔茨海默氏病和相关痴呆症中央存储库）。此外，行政核心将支持 VADRC 参与多中心临床试验。核心将成为促进下一代超级明星和科学家专业发展的组成部分总的来说，VADRC 行政核心将有助于建立和实施阿尔茨海默病。促进所有中心研究人员、合作者、核心职能、机构之间的协调整合资源和国家合作伙伴，这将有助于向未来 P30 资助的 VADRC 平稳过渡。