Vanderbilt Alzheimer's Disease Research Center

范德比尔特阿尔茨海默病研究中心

基本信息

批准号：
10470722
负责人：
ANGELA L. JEFFERSON
金额：
$ 168.97万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10470722
关键词：
Academic Medical Centers Adult African American African American population Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer&apos s disease therapeutic American Autopsy Award Awareness Basic Science Biological Markers Cerebrovascular Disorders Clinical Clinical Sciences Clinical Trials Cognitive Collaborations Communities Data Data Collection Data Set Dementia Development Early identification Educational Activities Educational Curriculum Educational workshop Elderly Elements Enrollment Environment Faculty Recruitment Fostering Foundations Functional disorder Funding Future Genetic Goals Grant Growth High Prevalence Incidence Infrastructure Injury Institution Intervention Knowledge Memory Mentorship Mission Molecular Participant Pathway interactions Phenotype Population Positioning Attribute Postdoctoral Fellow Prevention Prevention strategy Protocols documentation Relationship-Building Research Research Activity Research Infrastructure Research Institute Research Personnel Research Project Grants Resources Science Scientist Strategic Planning Students Techniques Technology Tennessee Training Translating Translational Research Universities Work bench to bedside clinical biomarkers clinical care clinical practice cohesion cohort community engagement community partnership cooperative study data acquisition dementia risk early-career faculty faculty support imaging genetics innovation interdisciplinary collaboration neuroimaging next generation novel therapeutics outreach precision medicine programs ranpirnase recruit repository resilience symposium tool training opportunity treatment strategy vascular injury

项目摘要

PROJECT SUMMARY – OVERALL This P20 application seeks to establish the Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) at Vanderbilt University Medical Center and Vanderbilt University in Nashville, Tennessee. The VADRC will leverage and build upon the foundational elements of the Vanderbilt Memory and Alzheimer’s Center created in 2012, including established outreach and recruitment pipelines as well as clinical, neuroimaging, genetic, and biospecimen data collection, processing, storage, and dissemination protocols. Simultaneously, the VADRC will establish essential infrastructure appropriate for a future P30 Alzheimer’s Disease Research Center with a focus on identifying molecular factors that increase Alzheimer’s disease risk or promote resilience. The VADRC mission will be to enhance knowledge to solve the complexities underlying the pathophysiology, early identification, and treatment of Alzheimer’s disease and related dementias. Our mission and goals align with the 2011 National Alzheimer’s Project Act. During the P20 award, we will establish Administrative, Clinical, and Biomarker Cores that work in harmony to facilitate and enhance innovative basic, translational, and clinical science in Alzheimer’s disease and related dementia across Vanderbilt’s campus. This effort will leverage rich precision medicine techniques and tools available at Vanderbilt and innovative pathways to identify novel therapeutics while supporting faculty recruitment and retention, integrated team science, and mentorship at all levels. The P20 mechanism will provide essential research resources and foster a strong intellectual community to support existing studies and enable new opportunities for transformative research. Within the Clinical Core, we will complete comprehensive clinical, cognitive, neuroimaging, genetic and biospecimen assessment on a newly established research cohort of aging adults ranging from cognitively unimpaired to mild Alzheimer’s disease, including neuropathological analyses as participants come to autopsy. Cross-Core and interdisciplinary collaborations throughout campus and with national repositories (including the National Alzheimer’s Coordinating Center) will support data collection, sharing, and dissemination. The VADRC will also enhance clinical relationships, community partnerships, and educational opportunities to promote awareness, increase research participation, and provide an interdisciplinary training environment. The Center will serve as the institutional hub of all research and educational opportunities in Alzheimer’s disease. Simultaneously, the VADRC will contribute to national efforts to advance Alzheimer’s disease research, clinical care, and educational activities by establishing relationships with other Alzheimer’s Disease Research Centers, contributing to national initiatives, and enhancing collaborations to maximize contributions to the field. The Center will be the first of its kind in the region and would help to serve the growing population of Tennesseans and southern Americans suffering from Alzheimer’s disease and related dementias.

项目概要——总体该 P20 申请旨在建立探索性范德比尔特阿尔茨海默病研究中心（VADRC）在范德比尔特大学医学中心和田纳西州纳什维尔的范德比尔特大学。 VADRC 将利用范德比尔特记忆和阿尔茨海默病的基本要素并以此为基础中心创建于 2012 年，包括已建立的外展和招募渠道以及临床、神经影像、遗传和生物样本数据收集、处理、存储和传播协议。同时，VADRC 将建立适合未来 P30 阿尔茨海默病的必要基础设施疾病研究中心专注于识别增加阿尔茨海默病风险的分子因素 VADRC 的使命是增强知识以解决潜在的复杂性。阿尔茨海默病和相关痴呆症的病理生理学、早期识别和治疗。使命和目标与 2011 年国家阿尔茨海默氏症项目法案一致。在 P20 奖期间，我们将设立。行政、临床和生物标志物核心协调一致，促进和增强创新基础、范德堡大学校园内阿尔茨海默病和相关痴呆症的转化和临床科学。这项工作将利用范德比尔特大学丰富的精准医学技术和工具以及创新识别治疗性小说的途径，同时支持教师招聘和保留，综合团队 P20 机制将提供必要的研究资源并促进各个层面的科学和指导。一个强大的知识界来支持现有的研究并为变革提供新的机会在临床核心领域，我们将完成全面的临床、认知、神经影像、遗传学研究。对新建立的老年人研究队列进行生物样本评估，范围从认知能力到未受到轻度阿尔茨海默病的影响，包括参与者进行尸检时的神经病理学分析。整个校园以及与国家存储库（包括国家阿尔茨海默病协调中心）将支持数据收集、共享和传播。 VADRC 还将加强临床关系、社区伙伴关系和教育机会，提高认识、增加研究参与并提供跨学科培训环境。该中心将成为阿尔茨海默病所有研究和教育机会的机构中心。同时，VADRC 将为国家推进阿尔茨海默病研究、临床治疗的努力做出贡献。通过与其他阿尔茨海默病研究中心建立关系来开展护理和教育活动，为国家举措做出贡献，并加强合作以最大限度地为该领域做出贡献。该中心将成为该地区第一个此类中心，并将有助于为不断增长的田纳西州人口提供服务以及患有阿尔茨海默病和相关痴呆症的南美洲人。