Validation of Video Administration of a Modified UDSv3 Cognitive Battery

改进的 UDSv3 认知电池的视频管理验证

• 批准号: 10370578
• 负责人: STEPHEN R RAPP
• 金额: $ 146.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370578
• 关键词: Academic Medical Centers; Achievement; Acute Respiratory Distress Syndrome; Address; Advisory Committees; Affect; Age; Agreement; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Assessment tool; Attention; COVID-19 pandemic; Characteristics; Classification; Clinical; Cognition; Cognitive; Data; Data Collection; Data Set; Dementia; Education; Elderly; Enrollment; Episodic memory; Ethnic Origin; Evaluation; Failure; Financial Hardship; Frail Elderly; Future; Geographic Locations; Geography; Goals; Gold; Individual; Interruption; Language; Measures; Medical center; Minority; Modality; Neuropsychology; Outcome; Participant; Persons; Population; Protocols documentation; Psychometrics; Race; Research; Rural Population; Short-Term Memory; Site; Standardization; Subgroup; Tablet Computer; Telephone; Testing; Time; Transportation; Traumatic Brain Injury; Travel; Underserved Population; United States National Institutes of Health; Update; Validation; Visit; adjudicate; adjudication; base; clinical care; cognitive testing; ethnic minority; executive function; forest; meetings; metropolitan; mild cognitive impairment; preference; prevent; programs; racial and ethnic; recruit; remote assessment; remote grading; response; satisfaction; success; tool; virtual; working group

Project Summary This multi-site R01 aims to validate video-administered cognitive assessments for use by the Alzheimer’s Disease Research Centers (ADRCs) and other research programs whose activities have been interrupted by the COVID-19 pandemic, as well as for use in future initiatives when remote testing will enhance achievement of scientific goals. While face-to-face administration is the gold standard for cognitive assessments, conditions often arise that prevent participants from attending in-person visits. These barriers include transportation challenges, limited mobility, and financial hardship. There is also evidence that underserved populations, including rural populations and racial/ethnic minorities, are less likely to enroll in studies that require travel to an academic medical center for face-to-face testing. The proposed study will address these challenges by utilizing a video-adapted battery incorporating the Uniform Data Set version 3 (UDSv3) measures with additional measures that may serve as alternatives for UDSv3 measures not adaptable to video administration. We propose to fully validate these assessment tools for remote administration in partnership with the NIA and the National Alzheimer’s Coordinating Center (NACC), and carried out by a consortium of 12 ADRCs. Pilot data was gathered from 88 Wake Forest ADRC participants, deemed by in-person testing and adjudication to have normal cognition, MCI, or dementia, who were tested either by phone or video. Data show high participant ratings of tolerability, feasibility, and preference for video versus telephone assessment. There is also high concordance between video-administered and in- person test scores. Based on this collective data, we plan to fully validate a video-version of the UDSv3 battery in a range of cognitively, ethnically, and geographically diverse participants. We propose to administer remote video cognitive assessments, paired alongside annual in-person cognitive assessments, in counterbalanced order, to 500 existing participants from 12 ADRCs utilizing a computer tablet device, including those previously adjudicated as having normal cognition, MCI and dementia. Participants’ ratings of satisfaction with test condition and preference of test modality will be obtained, in addition to the psychometric characteristics of the video battery relative to face-to-face administration, including concurrent validity, and estimates of relative bias overall and across important subgroups (age, ethnicity, cognitive status) and mode of administration of individual tests. Concordance between adjudication outcomes will also be examined to assess the ability of the battery to distinguish normal cognition, MCI and dementia. We will assess the sensitivity of the video battery to detect longitudinal change in cognition in ADRC participants by repeating counterbalanced, in-person and remote assessments 2 years following initial evaluation. Completion of this project is critical to the ongoing success of cognitive assessment in the ADRC network.

项目概要 这个多站点 R01 旨在验证视频管理的认知评估，供 阿尔茨海默病研究中心 (ADRC) 和其他研究项目的活动已 因 COVID-19 大流行而中断，以及在远程测试将增强的未来举措中使用 实现科学目标而面对面的管理是认知的黄金标准。 在评估过程中，经常会出现阻碍参与者亲自参加访问的情况。 包括交通挑战、流动性有限和经济困难。还有证据表明。 服务不足的人口，包括农村人口和少数种族/族裔，入学的可能性较小 需要前往学术医疗中心进行面对面测试的研究拟议的研究将。 通过使用包含统一数据集版本 3 的视频适配电池来应对这些挑战 (UDSv3) 措施以及可作为 UDSv3 措施替代方案的附加措施 我们建议充分验证这些远程评估工具。 与 NIA 和国家阿尔茨海默病协调中心 (NACC) 合作管理，以及 由 12 个 ADRC 组成的联盟进行，试点数据收集自 88 个维克森林 ADRC 参与者， 经现场测试和判定被认为具有正常认知、MCI 或痴呆症的人 数据显示，参与者对视频的容忍度、可行性和偏好程度较高。 电话评估与电话评估之间也存在高度一致性。 基于这些集体数据，我们计划全面验证 UDSv3 的视频版本。 我们建议对一系列认知、种族和地域不同的参与者进行电池测试。 远程视频认知评估与年度面对面认知评估相结合， 使用平板电脑设备向来自 12 个 ADRC 的 500 名现有参与者发出平衡订单，包括 那些先前被判定为具有正常认知、MCI 和痴呆症的参与者的评级。 此外，还将获得对测试条件和测试方式的偏好的满意度 与面对面管理相关的视频心理测量特征，包括 并发有效性，以及总体和重要亚组（年龄、种族、 认知状态）和各个测试之间的一致性的管理方式。 还将检查结果以评估电池区分正常认知、MCI 和 我们将评估视频电池检测 ADRC 认知纵向变化的敏感性。 通过在初次评估后 2 年内重复平衡的现场评估和远程评估来评估参与者 评估的完成对于 ADRC 认知评估的持续成功至关重要。 网络。