Mediterranean Dietary Intervention in Pediatric Hyperlipidemia

地中海饮食干预小儿高脂血症

• 批准号: 9339286
• 负责人: Marguerite Engler
• 金额: $ 9.05万
• 依托单位: NATIONAL INSTITUTE OF NURSING RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9339286
• 关键词: Adult; Affect; Anti-Inflammatory Agents; Anti-inflammatory; Area; Arteries; Atherosclerosis; Behavior Therapy; Biological Availability; Biological Markers; Blood Vessels; Cardiovascular system; Child; Childhood; Cholesterol; Coronary heart disease; Development; Diet; Dietary Factors; Dietary Intervention; Dietary Supplementation; Endothelial Cells; Event; Genetic; Goals; Health; Hyperlipidemia; Mediterranean Diet; Nitric Oxide; Omega-3 Fatty Acids; Plague; Platelet aggregation; Prevention; Risk; Science; Therapeutic; Triglycerides; Vasodilator Agents; early onset; endothelial dysfunction; high risk; improved; insight; lipid disorder; polyphenol

Atherosclerosis is a global concern and is a leading cause of cardiovascular events.1 Studies have shown that childhood cholesterol levels predict adult cholesterol levels, suggesting that children with high cholesterol levels are at high risk for atherosclerosis and early onset of coronary heart disease (CHD). Endothelial dysfunction, an important early event in the development of CHD,is present in children with high cholesterol levels before the formation of plagues within the arteries. The primary management of high cholesterol is lifestyle modification such as diet. Studies have shown that the Mediterranean diet is effective for the prevention of CHD. The cardioprotective effect of the Mediterranean diet may be attributed to the anti-oxidative and anti-inflammatory activities of the polyphenols abundant in the Mediterranean diet. Polyphenols are also known to improve vascular function by increasing the bioavailability of nitric oxide (NO), a potent endothelial-derived vasodilator. Several lines of evidence indicate that omega-3 fatty acid supplements also enhance endothelial function by stimulating release of NO from the endothelial cells, decreasing triglyceride concentration, and inhibiting platelet aggregation. Understanding the effect of dietary factors on biomarkers may provide insight into therapeutic strategies to reduce the burden of hyperlipidemia in children.

动脉粥样硬化是全球关注的问题，是心血管事件的主要原因。1研究表明，儿童胆固醇水平可以预测成人胆固醇水平，这表明胆固醇水平高的儿童患动脉粥样硬化和早期冠心病心脏病（CHD）的高风险。 内皮功能障碍是CHD发展的重要早期事件，在动脉内瘟疫之前具有高胆固醇水平的儿童。 高胆固醇的主要管理是生活方式的修改，例如饮食。 研究表明，地中海饮食对预防CHD有效。 地中海饮食的心脏保护作用可能归因于地中海饮食中多酚的抗氧化和抗炎活性。 还已知多酚通过增加一氧化氮（NO）的生物利用度（一种有效的内皮衍生的血管扩张剂）来改善血管功能。 几条证据表明，Omega-3脂肪酸补充剂还通过刺激从内皮细胞中释放NO，降低甘油三酸酯的浓度并抑制血小板聚集来增强内皮功能。 了解饮食因素对生物标志物的影响可能会提供对减轻儿童高脂血症负担的治疗策略的见解。