Core A: Administrative Core

核心A：行政核心

• 批准号: 10472763
• 负责人: DAVID ALAN BENNETT
• 金额: $ 26.61万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472763
• 关键词: Academic Medical Centers; Achievement; Address; Administrator; Advisory Committees; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapeutic; Biological Markers; Black Populations; Brain; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Communication; Communities; Data; Dementia; Development; Diagnosis; Disease; Ensure; Etiology; Exercise; Faculty; Family Study; Funding; Funding Mechanisms; Future; Generations; Genetic Diseases; Goals; Infrastructure; Institution; International; Investments; Knowledge; Latino; Leadership; Monitor; NCI Scholars Program; National Institute on Aging; Pathogenesis; Pharmacology; Phenotype; Population Study; Precision Health; Reporting; Research; Research Institute; Research Personnel; Resource Sharing; Resources; Review Committee; base; cohort; collaborative environment; data hub; design; education research; health equity; innovation; meetings; neuroimaging; new therapeutic target; precision medicine; summer internship; user-friendly

ABSTRACT – ADMINISTRATIVE CORE The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s dementia and related dementias (AD/ADRD). The Administrative (Admin) Core will exercise overall scientific leadership of the Rush ADRC to set the overall direction of the Rush ADRC, ensure optimal utilization of Rush ADRC resources, promote the implementation of the ADRD NAPA milestones, and serve as a resource for other aging and AD/ADRD activities at the national and local level. It will 1) ensure that each of the other Cores, and trainees reach their goals and greatest potential by establishing effective communication and interaction through the Executive Committee; 2) guide the use of institutional resources for the ADRC; 3) support a user- friendly mechanism to facilitate the use of Rush ADRC resources by the wider aging and AD/ADRD research community, locally, nationally, and internationally, through the Resource Distribution Committee; 4) identify and support high quality development projects and Rush ADRC Research Scholars; 5) ensure active and constructive participation in collaborative efforts with other organizations, advance research and knowledge of AD/ADRD, including RUMC, NIA ADRCs and other efforts; 6) monitor achievements and modify goals and future directions through the External Advisory Committee. These aims are supported through the careful design and integration of the Administrative Core with the other seven Cores and Research Education Component that comprise the Rush ADRC. The Rush ADRC addresses many of the NAPA Milestones including: 1) population studies via 3 community-based cohort studies and two affiliated cohort studies funded as R01s conducted by Rush ADRC investigators that are all harmonized to the ROS Core. They include multi-level, multi-region omic data for precision medicine and health equity as two cohorts are exclusively of Blacks and one of Latino and the two other studies are predominantly non-Latino white, 2) disease mechanisms via deep brain phenotyping, 3) translational clinical research – pharmacological through the generation of potential subjects for clinical trials, 4) biomarkers & diagnosis via neuroimaging and biofluid biomarkers, and 5) enabling infrastructure via our Resource Sharing Hub at https://www.radc.rush.edu/.

摘要 – 行政核心 拟议的 Rush ADRC 的总体目标是创建一个跨学科环境，以支持 阿尔茨海默病的病因、发病机制、诊断、治疗和预防的创新研究 和相关痴呆症 (AD/ADRD) 行政 (Admin) 核心将行使全面的科学领导作用。 Rush ADRC 的总体方向，确保 Rush ADRC 的最佳利用 资源，促进 ADRD NAPA 里程碑的实施，并作为其他资源 国家和地方层面的老龄化和 AD/ADRD 活动 它将 1) 确保其他每个核心，以及 学员通过建立有效的沟通和互动来实现他们的目标和最大潜力 通过执行委员会； 2) 指导 ADRC 机构资源的使用； 3) 支持用户； 通过更广泛的老龄化和AD/ADRD研究促进Rush ADRC资源的友好机制 4）通过资源分配委员会在地方、国家和国际范围内确定和 支持高质量的发展项目和Rush ADRC研究学者5）确保积极和 建设性地参与与其他组织的合作，推进研究和知识 AD/ADRD，包括 RUMC、NIA ADRC 和其他工作；6) 监控成果并修改目标； 通过外部咨询委员会确定未来的方向。 这些目标是通过行政核心与其他核心的精心设计和整合来支持的。 组成 Rush ADRC 的七个核心和研究教育组件 Rush ADRC 致力于解决这一问题。 NAPA 的许多里程碑包括：1) 通过 3 项基于社区的队列研究和 2 项人口研究 由 Rush ADRC 研究人员进行的作为 R01 资助的附属队列研究，这些研究均与 ROS Core。它们包括用于精准医疗和健康公平的多层次、多区域组学数据。 队列完全是黑人和拉丁裔，另外两项研究主要是非拉丁裔 白色，2）通过深部脑表型分析的疾病机制，3）转化临床研究 - 药理学 通过产生潜在的临床试验受试者，4）通过神经影像学进行生物标志物和诊断， 生物流体生物标志物，以及 5) 通过我们的资源共享中心启用基础设施 https://www.radc.rush.edu/。