Rush Alzheimer's Disease Research Center

拉什阿尔茨海默病研究中心

• 批准号: 10264493
• 负责人: DAVID ALAN BENNETT
• 金额: $ 312.77万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264493
• 关键词: Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Biological; Biological Markers; Biometry; Brain; Caregivers; Cell model; Clergy; Clinical; Cohort Studies; Communities; Crystallization; Data; Data Collection; Data Set; Dementia; Disease model; Education; Enrollment; Evaluation; Exercise; Faculty; Funding; Goals; Grant; Heterogeneity; Human; Impaired cognition; Incentives; Infrastructure; Institution; Latino; Leadership; Magnetic Resonance Imaging; Methodology; Molecular Profiling; Nature; Organ Donations; Participant; Pathogenesis; Patients; Persons; Pilot Projects; Positron-Emission Tomography; Prevention; Procedures; Process; Publishing; Recommendation; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Science; Source; Specimen; Strategic Planning; Structure; Systems Biology; Trust; Work; cohort; collaborative environment; community based research; computer infrastructure; computerized tools; data harmonization; data management; data sharing; distributed data; education research; ethnic minority population; follow-up; human data; innovation; multidisciplinary; neuroimaging; neuroimaging marker; neuropathology; new therapeutic target; open data; outreach; predictive modeling; programs; public health priorities; public-private partnership; racial and ethnic; racial diversity; racial minority; recruit; relational database; religious order study; repository; statistics; student mentoring; virtual

ABSTRACT – OVERALL The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on the causes, treatments, and prevention of AD/ADRD. While the proposed Rush ADRC is for a new grant, it builds on three decades of work by the current Rush ADCC. The Rush ADRC has eight cores and one component, which align with the recommendations of the 2017 NIA strategic plan, including studies that: 1) recognize the heterogeneity and multifactorial nature of dementias; 2) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; 3) employ new research paradigms, e.g., systems biology, human cell modeling; 4) enable rapid and extensive sharing of data, disease models, specimens, and support open and team science; 5) develop computational tools and infrastructure for storage, integration, and analysis of large-scale biological and patient-relevant data; 6) build multidisciplinary translational teams in virtual and real spaces; 7) develop new pre-competitive public-private partnerships; 8) change academic, publishing, and funding incentives to promote collaborative, transparent, and reproducible research; and 9) engage patients, caregivers, and citizens as direct partners in research. The Administrative Core will provide scientific leadership to the Rush ADRC as a whole. The Religious Orders Study (ROS) Core will recruit and conduct annual evaluations of Catholic clergy without dementia who agree to organ donation. The Clinical and Latino Cores will collect data harmonized with on Blacks and Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach, Recruitment, and Engagement Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical, ROS and Latino Cores, and other NIA funded initiatives. The Biomarker/Neuroimaging Core will process neuroimaging generated with other funds from all three Cores and affiliated studies, and document neuroimaging and biofluid biomarker data. The new Research and Education Component will provide structured mentoring of students and faculty at all levels. The Data Management and Statistical Core will provide the infrastructure that allows all other Cores and the REC to be maximally successful and impactful and will provide statistical support to users of ADRC resources especially junior investigators and trainees.

摘要 – 总体 拟议的 Rush ADRC 的总体目标是创建一个跨学科环境，以支持 AD/ADRD 的病因、治疗和预防方面的创新研究，同时提出了 Rush ADRC。 这是一项新的资助，它建立在当前 Rush ADCC 三十年的工作基础上。 Rush ADRC 有八项资助。 核心和一个组件，符合 2017 年 NIA 战略计划的建议，包括 研究：1）认识到痴呆症的异质性和多因素性质；2）支持广泛的研究； 分子分析填补了建立疾病预测模型所需的大规模人类数据的空白 健康；3）采用新的研究范式，例如系统生物学、人体细胞建模；4）实现快速和 广泛共享数据、疾病模型、标本，并支持开放和团队科学 5) 发展； 用于存储、集成和分析大规模生物和生物信息的计算工具和基础设施 患者相关数据；6）在虚拟和现实空间中建立多学科转化团队；7）开发新的 竞争前的公私合作伙伴关系；8）改变学术、出版和资助激励措施以促进 协作、透明和可重复的研究；9) 让患者、护理人员和公民参与其中 研究的直接合作伙伴。 行政核心将为整个 Rush ADRC 提供科学领导。 研究（ROS）核心将招募同意的无痴呆症天主教神职人员并进行年度评估 临床和拉丁裔核心将收集与黑人和拉丁裔协调一致的数据。 神经病理学核心将处理、存储、评估和进行脑部尸检。 分发临床、ROS 和拉丁裔核心获得的生物样本。 参与核心将提供广泛的教育计划，以支持外展和招聘 将种族和族裔纳入临床、ROS 和拉丁裔核心以及其他 NIA 资助的计划中。 生物标记/神经影像核心将处理由所有三个核心的其他资金生成的神经影像， 附属研究，并记录神经影像和生物流体生物标志物数据。 该组件将为各级学生和教师提供结构化指导。 统计核心将提供允许所有其他核心和 REC 最大化的基础设施 成功且有影响力，将为 ADRC 资源的用户，特别是初级用户提供统计支持 调查员和实习生。