Southern Environmental Health Study

南方环境健康研究

• 批准号: 10900880
• 负责人: Martha J. Shrubsole
• 金额: $ 264.6万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10900880
• 关键词: Address; Behavioral; Biological; Biological Markers; Biological Specimen Banks; Blood specimen; Cancer Etiology; Carcinogens; Chemicals; Cohort Studies; Collection; Communities; Coupled; Data; Disease; Dose; Environment; Environmental Carcinogens; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Pollutants; Ethnic Origin; Evaluation; Exposure to; Funding; Future; Geography; Health; Human; Incidence; Individual; Infrastructure; Investigation; Life Cycle Stages; Link; Low income; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Minority Groups; Obesity; Occupational; Outcome; Participant; Persons; Phenotype; Pollution; Predisposition; Protocols documentation; Race; Recording of previous events; Research; Resources; Risk; Risk Factors; Sampling; Surveys; Time; Tobacco smoking behavior; Unhealthy Diet; Variant; biomarker identification; built environment; cancer epidemiology; cancer risk; carcinogenesis; carcinogenicity; cohort; community engaged research; disorder risk; environment related cancer; epidemiology study; experience; exposed human population; follow-up; health inequalities; improved; instrument; metabolomics; mortality; multiple data sources; novel; physical inactivity; programs; recruit; remediation; response; sample collection; social; success; tool; unhealthy lifestyle; wearable device

SUMMARY Approximately 80% of human cancers are caused by adverse environmental exposures, unhealthy lifestyles and/or their interactions with host susceptibility factors. Previous studies have mostly focused on evaluating behavioral risk factors, such as tobacco smoking, physical inactivity, unhealthy diets and obesity. While more than 80,000 chemicals have been registered by the EPA, very few of them have been adequately investigated in relation to human cancers in epidemiologic studies. There are considerable challenges in studying environmental exposures in epidemiologic studies. Humans are exposed to large numbers of chemical and physical substances and their mixtures, typically at low levels over extended periods of time. Previous environmental epidemiologic studies have mostly evaluated exposures one at a time. However, because of a typically weak association of a given exposure with disease risk, coupled with limited tools and biomarkers for environmental assessments, most studies have failed to provide convincing evidence to link environmental exposures to cancer risk. To overcome these challenges, we propose to establish a large cohort study including ~50,000 participants with an extensive collection of survey and geospatial exposure data, as well as biological and environmental samples, to address critical issues in the environmental etiology of cancer. Utilizing a framework of community-engagement to help inform research, enhance recruitment and retention efforts, and disseminate results, we will focus on recruiting low-income and minority populations who are more likely to live in resource deprived and heavily polluted communities. We propose to include 1,500 of the study participants in a deep-exposome study to comprehensively assess the exposome, identify key biomarkers of external exposures, examine associations of external and internal metrics with cancer-related biological responses, and develop cumulative exposome risk scores. The proposed study will enable direct evaluation of associations of environmental exposures with cancer outcomes in the long term, and associations with cancer intermediate biomarkers in the short term. By integrating environmental exposure data from multiple sources, including personal exposure assessments and biologic markers of environmental exposure and responses, this proposed study will allow us to systematically and rigorously investigate environmental exposures in relation to cancer risk and provide substantial novel data to improve the understanding of both external and internal exposomes, which will pave the way for future remediation of environmentally induced cancer.

概括 大约 80% 的人类癌症是由不良环境暴露引起的， 不健康的生活方式和/或其与宿主易感因素的相互作用。之前的研究有 主要侧重于评估行为风险因素，例如吸烟、缺乏身体活动、 不健康的饮食和肥胖。虽然 EPA 已注册了 80,000 多种化学品，但 其中很少有人在流行病学研究中对它们​​与人类癌症的关系进行了充分的调查。 在流行病学研究中研究环境暴露存在相当大的挑战。 人类接触大量的化学和物理物质及其混合物， 通常在较长时间内处于低水平。先前的环境流行病学研究 大多数时候都是一次评估一项暴露。然而，由于通常弱关联 鉴于暴露于疾病风险，加上环境工具和生物标志物有限 评估中，大多数研究未能提供令人信服的证据将环境暴露联系起来 癌症风险。为了克服这些挑战，我们建议建立一项大型队列研究，包括 约 50,000 名参与者，收集了大量调查和地理空间暴露数据，以及 生物和环境样本，以解决癌症环境病因学中的关键问题。 利用社区参与框架来帮助为研究提供信息、加强招募和 保留努力并传播结果，我们将重点招聘低收入和少数族裔 更有可能生活在资源匮乏和污染严重的社区的人群。我们 建议将 1,500 名研究参与者纳入一项深度暴露研究，以全面了解 评估暴露组，确定外部暴露的关键生物标志物，检查外部暴露的关联 和与癌症相关的生物反应的内部指标，并开发累积暴露风险 分数。拟议的研究将能够直接评估环境暴露的关联 与癌症的长期结果以及与癌症中间生物标志物的关联 短期。通过整合来自多个来源（包括个人）的环境暴露数据 暴露评估以及环境暴露和反应的生物标记，建议 研究将使我们能够系统而严格地调查与 癌症风险并提供大量新数据以提高对外部和外部的了解 内部暴露体，这将为未来环境诱发的癌症的修复铺平道路。