Mouse Biology Shared Resource

小鼠生物学共享资源

• 批准号: 10624418
• 负责人: KC KENT LLOYD
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624418
• 关键词: Autopsy; Bariatrics; Basic Cancer Research; Biology; Breeding; CRISPR/Cas technology; Cancer Center Support Grant; Cancer Model; Center Core Grants; Clinical Pathology; Cohort Studies; Comprehensive Cancer Center; Consultations; Cryopreservation; Dedications; Derivation procedure; Disease model; Doctor of Philosophy; Embryo; Ensure; Funding; Gene Targeting; Generations; Genome; Genotype; Germ; Gnotobiotic; Goals; Health; Health Insurance Portability and Accountability Act; Image; Individual; Infrastructure; Intracytoplasmic Sperm Injections; Knock-in Mouse; Knock-out; Maintenance; Malignant Neoplasms; Microinjections; Microscopic; Microsurgery; Mission; Monitor; Mus; Mutagenesis; Mutant Strains Mice; Operative Surgical Procedures; Pathology; Phenotype; Point Mutation; Preparation; Process; Production; Productivity; Quality Control; Reproducibility; Reproductive Techniques; Research; Research Personnel; Research Support; Resource Sharing; Resources; Resuscitation; Scanning; Services; Slide; Speed; Stains; Technology; Telemetry; Training; Transgenic Organisms; Vendor; anticancer research; assisted reproduction; blastocyst; congenic; cost effectiveness; digital; disorder prevention; embryonic stem cell; experience; genome editing; germ free condition; homologous recombination; in vivo; interest; member; mouse model; patient derived xenograft model; preclinical study; professor; programs; response; screening; tissue preparation; transcriptome; translational cancer research

MOUSE BIOLOGY SHARED RESOURCE (MBSR) PROJECT SUMMARY/ABSTRACT The Mouse Biology Shared Resource (MBSR) provides unique, sophisticated, and comprehensive resources and services using mutant mice and murine cancer models for basic and translational cancer research for UC Davis Comprehensive Cancer Center (UCDCCC) members. The MBSR has provided research support to cancer researchers at the UCDCCC since its inception. The MBSR offers scientific expertise, customer assistance, technical training, specialized capabilities, unique services, and dedicated infrastructure for mouse embryo manipulation, genome mutagenesis, husbandry, production, phenotyping, and HIPAA-compliant patient derived xenograft (PDX) services. The overall objective of the MBSR is to provide UCDCCC members access to technologies, services, and scientific consultation that assists, facilitates, and supports the application of mouse models in cancer-related research. The MBSR is physically located in dedicated facilities strategically located between the Davis and Sacramento campuses in close proximity to and fully accessible by all UCDCCC members. By ensuring in vivo experimental reproducibility, reliability, cost-effectiveness, and quality control, the MBSR supports and promotes scientific interaction and productivity of UCDCCC researchers using mouse models to study cancer. Oversight and management of the MBSR is provided by the Director, K. C. Kent Lloyd, DVM, PhD, a Professor of Surgery (SOM) and Associate Director for SRs for the UCDCCC, who has extensive experience in mouse mutagenesis, phenotyping, and mouse modeling of disease, including cancer. The interests and productivity of UCDCCC members have generated increasing demand for mutant mouse services. With new genome editing capabilities (e.g., CRISPR/Cas9) and expansion of PDX models, the contributions made by the MBSR to cancer research is projected to continue to expand over the next 5 years. To enhance the scientific interaction and productivity of UCDCCC members, the MBSR will continue to provide cancer-related research support services. The Specific Aims for the MBSR are to: 1) Provide mouse modeling and creation services; 2) Provide mouse husbandry and maintenance services; and 3) Provide mouse genotyping and phenotyping services.

小鼠生物学共享资源 (MBSR) 项目概要/摘要 小鼠生物学共享资源 (MBSR) 提供独特、复杂且全面的资源 使用突变小鼠和小鼠癌症模型进行 UC 基础和转化癌症研究的服务和服务 戴维斯综合癌症中心 (UCDCCC) 成员。 MBSR 提供​​了研究支持 UCDCCC 自成立以来一直致力于癌症研究人员的工作。 MBSR 提供​​科学专业知识、客户 协助、技术培训、专业能力、独特的服务和鼠标专用基础设施 胚胎操作、基因组突变、饲养、生产、表型分析和 HIPAA 合规 患者来源的异种移植（PDX）服务。 MBSR 的总体目标是为 UCDCCC 成员提供 获得技术、服务和科学咨询，以协助、促进和支持 小鼠模型在癌症相关研究中的应用。 MBSR 实际位于专用设施中 地理位置优越，位于戴维斯校区和萨克拉门托校区之间，靠近并完全可到达 所有 UCDCCC 成员。通过确保体内实验的可重复性、可靠性、成本效益和 质量控制、MBSR 支持和促进 UCDCCC 的科学互动和生产力 研究人员使用小鼠模型来研究癌症。 MBSR 的监督和管理由 K. C. Kent Lloyd 主任，DVM，博士，外科教授 (SOM) 和 SR 副主任 UCDCCC，在小鼠诱变、表型分析和小鼠模型方面拥有丰富的经验 疾病，包括癌症。 UCDCCC会员的兴趣和生产力产生了越来越多的影响 对突变小鼠服务的需求。具有新的基因组编辑功能（例如 CRISPR/Cas9）和扩展 随着 PDX 模型的增多，MBSR 对癌症研究的贡献预计将继续扩大 未来5年。为了增强 UCDCCC 成员的科学互动和生产力，MBSR 将继续提供癌症相关研究支持服务。 MBSR 的具体目标是： 1) 提供鼠标建模及创作服务； 2）提供小鼠饲养及维护服务；和 3）提供小鼠基因分型和表型分析服务。