Animal Core

动物核心

基本信息

批准号：
10588973
负责人：
Kristin Nicole Grimsrud
金额：
$ 9.78万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588973
关键词：
Acclimatization Age Animal Model Animals Area Authorization documentation Autopsy Bariatrics Behavior Biology Cannulations Caring Clustered Regularly Interspaced Short Palindromic Repeats Collection Communicable Diseases Comparative Pathology Complex Containment Data Data Collection Dedications Derivation procedure Diabetes Mellitus Diabetic mouse Disease Enrollment Ensure Environment Fee-for-Service Plans Gender Generations Genetic Gnotobiotic Goals Health Health Services Health Status Histopathology House mice Housing Human Resources IACUC Immunohistochemistry Individual Institution Laboratories Maintenance Metabolic Mission Modeling Molecular Monitor Movement Mus Obesity Operative Surgical Procedures Pathology Phenotype Physiological Privatization Procedures Production Qualifying Quarantine Reproducibility Research Research Personnel Resources Rodent Scientist Service delivery model Services Specialist Students Surgical Models Telemetry Testing Transgenic Organisms Veterinarians Virus Work animal care authority bariatric surgery behavioral phenotyping cohort comorbidity cost cost effective environmental enrichment for laboratory animals genetic manipulation genome editing germ free condition implantation insight laboratory facility medical specialties meetings metabolic phenotype mouse model operation programs public repository repository

项目摘要

ABSTRACT—ANIMAL CORE The goal of the Center is to provide complex metabolic, physiologic, and behavioral phenotyping and consulting services to characterize living mouse models on a fair fee-for-service basis. To do so requires a Center to receive, house, feed, monitor, and maintain the health of mice submitted for phenotyping by investigators. Therefore, the Animal Core will import and provide optimal husbandry care and high-quality animal health services for mice sent and enrolled for testing at the Center, provide a number of specialty services, including surgical manipulation services, molecular, and pathology, upon request, and make facilitate access to disease-relevant mouse models from repositories or derive and create mouse models of diabetes and/or obesity de novo for testing at the Center. The Animal Core will be staffed by a Leader, co-Leader, and Core Coordinator. The Animal Core will fulfill its mission by pursuing the following 3 Specific Aims: Specific Aim 1: Receive, house, feed, monitor and maintain health of mice. Specific Aim 2: Manage, organize, and coordinate movement of mice for phenotyping. Specific Aim 3: Expand utilization of the Center to investigators with or without mice. The Animal Core will have the institutional resources and authority to import and acclimate mice meeting certain minimal health standards for further phenotypic analysis with minimal delay into dedicated vivarium facilities. This high-throughput and multifunctional Core will broaden the availability of metabolic models and phenotyping tests by enabling investigator mice to be analyzed, expediting data generation and interpretation, and ultimately complete testing projects in a timely fashion and for reasonable cost.

摘要—动物核心该中心的目标是提供复杂的代谢、生理和行为表型分析以及在公平的收费基础上提供活体小鼠模型表征的咨询服务。接收、饲养、喂养、监测和维护提交表型分析的小鼠健康的中心因此，动物核心将进口并提供最佳的饲养护理和高质量。动物健康服务中心为送去并登记在中心进行检测的小鼠提供多项专业服务根据要求提供服务，包括手术操作服务、分子和病理学服务，并提供便利从存储库获取与疾病相关的小鼠模型或衍生并创建糖尿病小鼠模型和/或从头开始肥胖症在中心进行测试，动物核心将配备一名领导者、联合领导者和核心协调员。动物核心将通过追求以下 3 个具体目标来履行其使命：具体目标 1：接收、安置、喂养、监测和维持小鼠的健康。具体目标 2：管理、组织和协调小鼠的运动以进行表型分析。具体目标 3：将中心的利用范围扩大到有或没有小鼠的研究人员。动物核心将拥有机构资源和权力来进口和适应小鼠会议进一步表型分析的某些最低健康标准，并尽可能减少进入专用饲养室的延迟这种高通量和多功能的核心将扩大代谢模型和的可用性。通过对研究小鼠进行分析、加快数据生成和解释来进行表型测试，并最终以合理的成本及时完成测试项目。