Mouse Production, Testing, and Research Support Core

鼠标生产、测试和研究支持核心

基本信息

批准号：
10685453
负责人：
KC KENT LLOYD
金额：
$ 38.85万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10685453
关键词：
Accreditation Alzheimer&apos s Disease Authorization documentation Autopsy Bioinformatics Biology Biometry Blood Blood specimen Brain Breeding Caring Cognitive Communication Containment Data Dedications Diet Direct Costs Disease Surveillance Electrophysiology (science)Ensure Faculty Female Future Genotype Goals Harvest Health Healthcare Individual Infrastructure Intervention Investigation Ketoses Ketosis Label Leadership Liquid substance Longevity Methods Monitor Mus Phenotype Production Readiness Research Research Project Grants Research Support Resources Sampling Schedule Scientist Services Structure Technical Expertise Testing Therapeutic Tissue Preservation Translations Update Wild Type Mouse Work aged authority behavioral phenotyping clinical application cohort experience male metabolic phenotype mouse model mutant neurobehavioral neurochemistry neuropathology operation phenotypic data preclinical study programs sample collection

项目摘要

Project Summary – Mouse Production, Testing, and Research Support Core (Core C) Core C, the Mouse Production, Testing, and Research Support Core, will provide mice and mouse services for study in all four research projects proposed in this program project. Specifically, the Core will expand and manage breeding colonies of mutant and wildtype mice, provide husbandry and health care, administer test diets, and ensure the identity, availability, and accessibility of all mice that will be used for research. In addition, the Core will harvest, collect, label, record, and preserve tissue and fluid (e.g., blood, brain) samples from individual mice and deliver samples to the appropriate project(s) for analysis. Moreover, the Core will be responsible for conducting specific cognitive and behavioral phenotyping tests on mouse lines. Finally, the Core will provide expertise in preclinical studies using Alzheimer's disease mouse models and facilitate future translation to clinical applications. Data collected and recorded from these tests will be delivered to Core B, the Biostatistics and Bioinformatics Core and to the relevant research project(s) for analysis and interpretation, respectively. Core C will also work closely with Core A, the Administrative Core, to streamline and efficiently coordinate activities between all four research projects. With its technical and faculty expertise and committed program infrastructure, Core C is uniquely prepared to accomplish these objectives.

项目概要 – 鼠标生产、测试和研究支持核心（核心 C） Core C，即小鼠生产、测试和研究支持核心，将提供小鼠和小鼠具体来说，核心将为本计划项目中提出的所有四个研究项目提供研究服务。扩大和管理突变型和野生型小鼠的繁殖群体，提供饲养和医疗保健，管理测试饮食，并确保将用于实验的所有小鼠的身份、可用性和可及性此外，核心还将收获、收集、标记、记录和保存组织和液体（例如血液、大脑）样本，并将样本运送到适当的项目进行分析。核心将负责对小鼠品系进行特定的认知和行为表型测试。最后，核心将提供使用阿尔茨海默病小鼠模型进行临床前研究的专业知识和促进未来从这些测试中收集和记录的数据转化为临床应用。交付给核心 B、生物统计学和生物信息学核心以及相关研究项目核心 C 也将分别与核心 A（行政核心）密切合作，以凭借其技术和师资力量，简化并有效地协调所有四个研究项目之间的活动。凭借专业知识和坚定的计划基础设施，Core C 为实现这些目标做好了独特的准备。