NORTHWESTERN Alzheimer's Disease Research Center

西北阿尔茨海默病研究中心

• 批准号: 10469445
• 负责人: ROBERT J VASSAR
• 金额: $ 344.35万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10469445
• 关键词: Accreditation; Address; Administrator; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Area; Autopsy; Award; Biological Markers; Biology; Biometry; Businesses; Clinical; Clinical Investigator; Cognitive aging; Collaborations; Consultations; DNA; Data; Data Store; Dementia; Development; Disease; Early Diagnosis; Education; Education and Outreach; Educational Status; Ensure; Etiology; Extramural Activities; Faculty; Family; Fellowship; Funding; Goals; Grant; Healthcare; Heterogeneity; Human Resources; Image; Individual; Institution; Intervention; Laboratories; Leadership; Life; Microglia; Modality; Nerve Degeneration; Neuropsychology; Parents; Participant; Pathology; Pathway interactions; Patient Recruitments; Patients; Plasma; Play; Positron-Emission Tomography; Primary Progressive Aphasia; Research; Research Personnel; Research Priority; Research Support; Resources; Risk Factors; Role; Scientist; Slide; Standardization; Syndrome; Time; Tissue Sample; Tissues; Training; Training Programs; Translational Research; Underrepresented Populations; Underserved Population; United States; Universities; Work; aging brain; base; beneficiary; brain tissue; clinical diagnosis; cognitive neuroscience; cohort; data management; design; diagnostic criteria; education research; imaging biomarker; innovation; interest; member; middle age; multidisciplinary; multimodal neuroimaging; neuroinflammation; neuropathology; novel; outreach; participant retention; programs; protein TDP-43; ranpirnase; recruit; responsible research conduct; statistics; tau Proteins; translational approach

PROJECT SUMMARY - OVERALL COMPONENT The Northwestern ADRC is in its 25th year. This renewal application describes the progress of the past cycle and a plan of action for the next 5 years, during which we will pursue the following principal goals: 1) Support innovative research at Northwestern University on the biology, early diagnosis, risk factors, and treatment of dementias by bringing together basic and clinical investigators. 2) Participate in national collaborations that leverage the strengths of the NIA Centers by using the UDS-3 and FTLD Module and transmitting data to NACC, and participating in ADNI, ADCS, NCRAD, LOAD, ADGC, and FTLD-related consortia. 3) Serve a leadership role in FTLD neuropathology, primary progressive aphasia (PPA), dementias associated with TDP-43 pathology, mid-life onset AD (MOAD), microglia and neuroinflammation, and unusually successful brain aging (SuperAging) in keeping with the unique strengths of the Northwestern ADRC in this area of aging and dementia research. 4) Train fellows and junior faculty and attract new investigators to dementia research through accredited clinical fellowships, Development Project awards, and training grants. 5) Ensure that patients, families, and underserved populations are beneficiaries of relevant advances through education, outreach, and novel life enrichment programs. The cores of the ADRC are configured to serve the specific goals listed above. The Administrative Core will be responsible for the clinical, scientific and fiscal leadership of the entire ADRC, as well as the coordination with national consortia and the selection of Development Projects. The Clinical Core will maintain a cohort of well- characterized subjects recruited to address ongoing research priorities. The Data Management and Statistics Core will ensure that the data are stored in ways that maximize collaboration and that biostatistical consultation plays a key role in the design and interpretation of research. The Neuropathology Core will characterize patients who come to autopsy according to up-to-date criteria, and distribute tissue, slides, DNA, and data for local and national collaborations. The Outreach, Recruitment and Engagement Core will work with the Clinical Core to enhance participant recruitment and retention in the ADRC, and will develop innovative life enrichment programs to serve patients and their families. The Research Education Component will oversee diversity recruitment for researchers and junior faculty and coordinate training requirements for the Responsible Conduct of Research. The Imaging Biomarker Core will perform up-to-date multimodal neuroimaging of Clinical Core participants, including amyloid and tau PET. The Executive Committee, composed of all key personnel, will formulate ADRC priorities based on local and national mandates and will review requests for patients, controls, tissue, and data.

项目概要 - 总体组成部分 西北 ADRC 已成立 25 年。此更新申请描述了上一个周期的进度 以及未来5年的行动计划，在此期间我们将追求以下主要目标： 1) 支持西北大学在生物学、早期诊断、危险因素和疾病方面的创新研究 通过汇集基础和临床研究人员来治疗痴呆症。 2) 通过使用 UDS-3 参与利用 NIA 中心优势的国家合作 和FTLD模块并向NACC传输数据，并参与ADNI、ADCS、NCRAD、LOAD、 ADGC 和 FTLD 相关联盟。 3) 在 FTLD 神经病理学、原发性进行性失语症 (PPA)、痴呆症方面发挥领导作用 与 TDP-43 病理学、中年发病 AD (MOAD)、小胶质细胞和神经炎症相关，以及 异常成功的大脑老化（超级老化），符合西北地区的独特优势 ADRC 致力于衰老和痴呆症研究这一领域。 4) 通过认可培训研究员和初级教师并吸引新的研究人员参与痴呆症研究 临床奖学金、开发项目奖和培训补助金。 5) 确保患者、家庭和服务不足的人群成为相关进步的受益者 通过教育、外展和新颖的生活丰富计划。 ADRC 的核心被配置为服务于上面列出的特定目标。行政核心将是 负责整个 ADRC 的临床、科学和财务领导，以及与 国家财团和开发项目的选择。临床核心将维持一批优秀的 为解决正在进行的研究重点而招募的特定受试者。数据管理与统计 Core 将确保以最大化协作和生物统计咨询的方式存储数据 在研究的设计和解释中发挥着关键作用。神经病理学核心将表征 根据最新标准进行尸检的患者，并分发组织、切片、DNA 和数据 地方和国家合作。外展、招聘和参与核心将与临床部门合作 加强 ADRC 参与者招募和保留的核心，并将开发创新的生活丰富方式 为患者及其家人提供服务的计划。研究教育部分将监督多样性 招聘研究人员和初级教师并协调负责人的培训要求 研究的进行。成像生物标志物核心将执行临床的最新多模式神经成像 核心参与者包括淀粉样蛋白和 tau PET。执行委员会由所有主要人员组成， 将根据地方和国家的要求制定 ADRC 优先事项，并将审查患者的请求， 控制、组织和数据。