Northwestern ADRC Non competing supplement application

西北 ADRC 非竞争性补充申请

• 批准号: 10577047
• 负责人: ROBERT J VASSAR
• 金额: $ 28.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577047
• 关键词: Administrative Supplement; Autopsy; Brain; Budgets; Chemicals; Clinical; Enrollment; Excision; Funding; Growth; Home; Hospital Departments; Hospitals; Inpatients; Medicine; Participant; Pathology; Patients; Physicians; Policies; Reagent; Research; Services; Shipping; Structure; Time; cost; hospice environment; neuropathology; pandemic disease; programs; ranpirnase; tissue processing

On behalf of the Northwestern ADRC, we are submitting this supplement application to request funding for expenses that were not requested in our P30 budget to support our brain autopsy program, because they were not required at the time of our initial application. As of January 2022, the Northwestern Memorial Hospital (NMH) Department of Pathology changed their billing policy for all hospital-incurred autopsies. Up to that date, all autopsies on any patient who was affiliated with a Northwestern Medicine physician were complimentary, including those obtained for the research participants enrolled in the Northwestern ADRC Clinical Core. All costs were covered including those for brain removal and storage and tissue processing. From January 2022 onward, this policy has changed such that free autopsies are provided only on those patients who expire while they are inpatients admitted to the hospital at NMH. Since most of our participants die at home or in hospice or at another hospital, we will require additional funding that was not requested in our prior applications, particularly in the last 5 year competing renewal, funded in 2021. As a result, the current application is requesting a supplement to cover the costs of brain autopsies carried out in the Department of Pathology at NMH for the Northwestern ADRC Clinical Core. Our Center estimates to conduct 50 brain autopsies per year at NMH. The request (see budget justification) includes the cost for brain removal and storage, tissue processing, and chemicals and reagents required for storage and processing. In addition, on occasion, our ADRC Neuropathology Core is asked to assist in brain removal for a participant at another ADRC who lives close to our facility. We are thus also asking for costs to cover brain removal, storage and shipping for those instances. Our brain autopsy program has been highly successful and even during the pandemic benefitted from the Department of Pathology's careful adjustments to allow safe brain removal of participants who have died since the pandemic began.

我们代表西北 ADRC 提交此补充申请，以请求资助 我们的 P30 预算中没有要求用于支持我们的脑尸检计划的费用，因为它们是 我们初次申请时不需要。截至 2022 年 1 月，西北纪念医院 (NMH) 病理科更改了所有医院进行尸检的计费政策。截至该日期， 对西北医学医师附属的任何患者进行的所有尸检都是免费的， 包括为参加西北 ADRC 临床核心的研究参与者获得的数据。全部 费用包括脑切除和储存以及组织处理的费用。 2022年1月起 此后，这项政策发生了变化，仅对那些在死亡期间过期的患者提供免费尸检。 他们是 NMH 医院收治的住院患者。由于我们的大多数参与者死在家里或临终关怀中心或 在另一家医院，我们将需要我们之前申请中未要求的额外资金， 特别是在 2021 年资助的过去 5 年竞争续签中。因此，当前的申请是 请求补贴以支付病理科进行的脑部尸检费用 NMH 代表西北 ADRC 临床核心。我们中心预计每年进行 50 次脑部尸检 在 NMH。该请求（参见预算理由）包括脑切除和储存、组织的费用 加工，以及储存和加工所需的化学品和试剂。此外，有时我们的 ADRC 神经病理学核心被要求协助另一位居住在 ADRC 的参与者进行脑切除手术 靠近我们的设施。因此，我们还要求支付这些人的脑切除、储存和运输费用。 实例。我们的脑部尸检计划非常成功，甚至在大流行期间也受益 病理学部经过仔细调整，以允许安全地切除患有以下疾病的参与者的大脑： 自大流行开始以来就去世了。