Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)

百岁老人及其后代对阿尔茨海默病的抵抗力/抵抗力 (RADCO)

基本信息

批准号：
10532568
负责人：
Stacy Andersen
金额：
$ 33.3万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10532568
关键词：
Address Administrative Supplement African American African American population Age Aging Alzheimer&apos s Disease Alzheimer’s disease biomarker Amyloid beta-42 Anatomy Area Autopsy Binding Sites Biological Blood specimen Boston Brain Brain imaging COVID-19 Centenarian Characteristics Clinical Data Cognition Cognitive Collection Communities Consensus Data Data Analyses Data Collection Databases Diffusion Magnetic Resonance Imaging Disease Marker Enrollment Ensure Fasting Funding Future Gene Expression Generations Genetic Markers Genetic Transcription Goals Heart Hispanic Human Image Image Analysis Impaired cognition Impairment International Investigation Knowledge Portal Lead Light Link Location Longevity Los Angeles Magnetic Resonance Imaging Measures Memory Mission Modality Modeling Molecular Morphologic artifacts Neurocognitive Neuropsychological Tests Neuropsychology New York City Noise Outcome Output Parents Participant Pathologic Patient Recruitments Phenotype Physiologic pulse Plasma Population Predisposition RNA Race Resistance Resolution Resource Sharing Rest Sampling Sampling Studies Scanning Secure Septuagenarian Site Spouses Standardization Statistical Data Interpretation Structure System Techniques Testing Time Tissues Training Travel Universities Utah Work aged arterial spin labeling base biobank cognitive ability cognitive function cohort connectome cytokine data acquisition data de-identification data integration data management data repository data sharing design experience image processing imaging facilities metropolitan neurofilament neuroimaging neuropathology normal aging offspring parent grant parent project participant enrollment phenotypic biomarker phenotypic data preservation prisma recruit research study resilience statistics success symposium time interval tool transcriptomics virtual willingness

项目摘要

PROJECT SUMMARY/ABSTRACT The NIA funded parent project, 1U19AG073172, “Resilience/Resistance to Alzheimer’s Disease in Centenarians and their Offspring (RADCO)” seeks to characterize cognitive resilience or brain resistance to AD and to discover the underlying and hopefully translatable biological mechanisms that enable centenarian cognitive superagers to maintain cognitive function typical of cognitively intact septuagenarians. To address reviewers’ concerns that African Americans (n=88 or 7.2%) are underrepresented in the RADCO sample and that too few centenarians (n=75 or 15% of the total neuroimaged sample) undergo neuroimaging, this administrative supplement application seeks to fund a fourth phenotyping and biospecimen core and neuroimaging core site at Georgia State University (GSU). The GSU site will enhance the diversity of the RADCO cohort by enrolling 234 African Americans, thus increasing the proportion of the RADCO sample that is African American from 7.2% (88/1216) to 22.2% (322/1450). GSU is also able to be a fourth neuroimaging site for RADCO as it has a Prisma MRI platform and routinely performs the key structural and resting state functional pulse sequences that are identical to those used by the three current neuroimaging centers of the Neuroimaging Core as well as the Human Connectome-Aging project. We anticipate that about half (n=103) of the Atlanta-based participants will undergo neuroimaging. Of these 103 additional neuroimaged participants, we estimate 44 will be centenarians. These 44 centenarians added to the RADCO-wide sample of 150 centenarians will bring the proportion of centenarians who are neuroimaged to 34% (194/573). Dr. Vonetta Dotson’s expertise and demonstrated success in engaging the local African American community for enrollment in research studies provides RADCO with the opportunity to substantially increase our African American participant enrollment that will provide an adequately powered sample to discern race-specific differences and similarities in determinants or markers of cognitive superaging. The conduct of this African American participant enrollment effort at GSU provides the added benefit and rare opportunity to collaborate with the Georgia State/Georgia Tech Center for Advanced Brain Imaging (CABI), led by Vince Calhoun, to increase our sample of participants undergoing the rigorously standardized neuroimaging component of the Study.

项目概要/摘要 NIA 资助的父项目 1U19AG073172，“阿尔茨海默病的恢复力/抵抗力” 百岁老人及其后代 (RADCO)”旨在描述 AD 的认知弹性或大脑抵抗力并发现潜在的、有望转化的生物机制，使百岁老人能够认知超级老人维持认知功能完整的七十多岁老人的典型认知功能。审稿人担心非裔美国人（n=88 或 7.2%）在 RADCO 样本中代表性不足，并且接受神经影像检查的百岁老人（n=75 或总神经影像样本的 15%）太少，这行政补充申请旨在资助第四个表型分析和生物样本核心项目乔治亚州立大学 (GSU) 的神经影像核心站点将增强乔治亚州立大学 (GSU) 的多样性。 RADCO 队列招募了 234 名非裔美国人，从而增加了 RADCO 样本的比例非洲裔美国人从 7.2% (88/1216) 到 22.2% (322/1450) 也能够成为第四个神经影像学。 RADCO 的站点，因为它拥有 Prisma MRI 平台，并定期执行关键的结构和静息状态功能脉冲序列与当前三个神经影像中心使用的脉冲序列相同我们预计大约有一半 (n=103) 的神经影像核心和人类连接组老化项目。亚特兰大的参与者将接受神经影像检查，在这 103 名额外的神经影像参与者中，我们估计将有 44 名百岁老人。这 44 名百岁老人被添加到 RADCO 范围内的 150 名百岁老人中。百岁老人将使接受神经影像检查的百岁老人比例达到 34% (194/573)。多特森的专业知识和在吸引当地非裔美国人社区参与方面取得的成功研究性学习的入学为 RADCO 提供了大幅提高非洲研究能力的机会美国参与者注册将提供足够有力的样本来辨别特定种族认知超老化的决定因素或标记的差异和相似之处。 GSU 的美国参与者注册工作提供了额外的好处和难得的合作机会与文斯·卡尔霍恩 (Vince Calhoun) 领导的佐治亚州/佐治亚州高级脑成像技术中心 (CABI) 合作，增加接受严格标准化神经影像学部分的参与者样本学习。