WG2: Virology and Cure

WG2：病毒学和治疗

• 批准号: 9262317
• 负责人: DAVID J MCDONALD
• 金额: $ 0.78万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9262317
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Area; Biological; Biological Assay; Biology; CD4 Positive T Lymphocytes; Cardiovascular system; Cells; Collaborations; Comorbidity; Development; Discipline; Fertilization; Fostering; Funding; Goals; Grant; HIV; HIV Infections; HIV/HCV; Health; Hepatitis C co-infection; Immune; Impairment; In Vitro; Integration Host Factors; Journals; Link; Lymphoid Tissue; Mentors; Molecular; Morbidity - disease rate; Paper; Pathogenesis; Pathway interactions; Patients; Prevention; Public Health; Publishing; Research; Research Personnel; Research Priority; Resources; Scientist; T-Lymphocyte Subsets; Tissues; Translating; Vaccines; Viral; Virus Latency; Virus Replication; Work; adverse outcome; base; career; clinical investigation; co-infection; design; effective therapy; improved; in vivo; latent infection; meetings; member; novel; pandemic disease; reactivation from latency; reproductive tract; small molecule; success; transmission process; virology; working group

Project Summary Virology and Cure Research priorities in the ART era have shifted, and strategies to block HIV transmission, eradicate latent HIV reservoirs through a functional or sterilizing cure, and mitigate adverse outcomes of co-infections and comorbidities in infected patients are now major priorities. WG 2 consists of 24 CFAR members whose research is focused on the molecular and cell biological aspects of HIV related to these priorities: viral replication, restriction factors, and transmission (prevention); latency, reactivation, and elimination of reservoirs (cure); enhanced morbidity due to viral co-infections. The group has published 189 papers during the last funding cycle. The primary goal of WG2 is to promote interactions and collaborations between researchers at CWRU and beyond to unravel the biology behind HIV transmission, latency, and viral co-infections and translate these into effective therapies. WG2 promotes this scientific agenda through a variety of activities including (1) facilitating collaborative research by sponsoring seminars, journal clubs, research-in-progress meetings, and targeted meetings to discuss HIV initiatives, (2) forming and participating in national research consortia to promote and disseminate HIV research, and (3) mentoring and promoting the careers of junior investigators. Through these activities, WG2 will promote the following Specific Aims: • To develop new interactions among investigators from various disciplines. • To stimulate the formation of multi-investigator projects. WG2 success will be defined by the advancement of new collaborative projects, including: • To stimulate cross-fertilization between working groups. In summary, WG2 is focused on promoting key scientific priorities for HIV research in the ART era. This agenda will be supported through targeted activities designed to foster collaborations within the CWRU/UH CFAR, develop supporting resources in the CFAR Cores and led and participate in national consortia in these areas. The WG2 has placed emphasis on engaging new investigators and has an excellent record of supporting the work of Mentored Scientist Pilot Grant and Catalytic Fund awardees.

项目摘要病毒学和治疗 艺术擦除的研究重点已经发生了变化，以及阻止艾滋病毒传播的策略，放射线潜伏 通过功能或消毒治疗，HIV水库，减轻共同感染和合并症的不良结果 在受感染的患者中，现在是重点。 WG 2由24个CFAR成员组成，其研究是 侧重于与这些优先级相关的HIV的分子和细胞生物学方面：病毒复制，限制 因素和传播（预防）；储层的潜伏期，重新激活和消除（治疗）；增强 病毒共感染引起的发病率。该小组在上一个融资周期中发表了189篇论文。 WG2的主要目标是促进CWRU及其他地区研究人员之间的互动和合作 阐明HIV传播，潜伏期和病毒共同感染背后的生物学，并将其转化为有效 疗法。 WG2通过各种活动，包括（1）支持协作，促进了这一科学的Agernda 赞助的SEMIAR，期刊俱乐部，进行研究的会议以及针对性会议的研究 讨论艾滋病毒倡议，（2）成立和参与国家研究联盟以促进和传播 艾滋病毒研究，以及（3）心理和促进初级研究人员的职业。通过这些活动，WG2 将促进以下特定目标： •开发来自各个学科的研究人员之间的新互动。 •刺激多投票程序项目的形成。 WG2成功将由 新合作项目的进步，包括： •刺激工作组之间的交叉施用。 总之，WG2专注于促进艺术时代的艾滋病毒研究的关键科学重点。这 议程将通过旨在促进CWRU/UH中的合作的有针对性活动来支持 CFAR，在CFAR内核中开发支持资源，并在这些中领导并参与国家财团 区域。 WG2重点是吸引新的调查人员，并有很好的支持记录 指导的科学家飞行员赠款和催化基金获奖者的工作。