Core-003: Functional Assessment Core

Core-003：功能评估核心

• 批准号: 9087507
• 负责人: Daniel E Michele
• 金额: $ 26.81万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9087507
• 关键词: Adopted; Affect; Animal Model; Animal Organ; Animals; Area; Biology; Biophysics; Collaborations; Communities; Data; Development; Disease; Disease Pathway; Education; Engineering; Equipment; Experimental Designs; Financial Support; Future; Goals; Health; Hereditary Disease; Human; Inbred Strain; Individual; Institution; Integrative Medicine; Knowledge; Laboratories; Lead; Ligaments; Measurement; Measures; Mechanics; Methodology; Michigan; Mission; Modeling; Molecular; Mus; Muscle function; Musculoskeletal; Musculoskeletal Diseases; Organ; Organism; Outcome; Output; Patients; Phenotype; Physiological; Physiology; Procedures; Rattus; Recommendation; Research; Research Personnel; Resolution; Resource Sharing; Resources; Rodent; Sampling; Services; Standardization; Structure; Techniques; Technology; Tendon structure; Testing; Tissues; Training; Universities; Validation; base; bone; cost; design; genetic manipulation; genetic technology; improved; in vivo; insight; investigator training; neuromuscular function; new technology; operation; pre-clinical therapy; research study; technology development; therapy development; wasting

Michigan Integrative Musculoskeletal Health Core Center – Core D Project Summary Functional assessment of musculoskeletal phenotypes in animal models is critical to identifying mechanisms of how diseases affect the integrative health and function of patients suffering from various musculoskeletal conditions. The ability to study musculoskeletal phenotypes across a wide-ranging scale requires considerable expertise and highly specialized training in physiology, biophysics, and engineering, as well as access to costly, high-resolution, state-of-the-art equipment. While occasionally the expertise and equipment for single approaches can be developed in a single laboratory, developing these approaches can be cost prohibitive, redundant, and can lead to proliferation of non-uniform techniques across the field. The Functional Assessment Core (Core D) will bring together the animal, organ, tissue, and in some cases cellular level phenotyping capabilities currently used within individual laboratories at the University of Michigan into a cohesive and easily accessible core service that can be used by the entire musculoskeletal research community. Core D will integrate individual laboratory approaches to musculoskeletal biology and engineering by including state-of-the-art measurements in bone mechanics, muscle function and mechanics, and tendon mechanics. This will be implemented through prioritization of experiments for hypothesis-based testing, coordination of cross-core experiments, execution of high precision phenotyping studies, and collaboration among investigators within and external to the institution. Core D will also focus on expanding its offerings to both enhance the capabilities of the current Research Community and to further expand the breadth and depth of the Core Center. Four Aims are proposed: the Core will provide expertise and guidance on the design of experiments in Aim 1, and access in Aim 2 to state-of-the-art technologies and experts to allow quantification of animal, organ, and tissue function and to provide training in these methodologies. Further, in Aim 3, the Core will provide guidance with interpretation of results and make recommendations for future studies. Lastly, the overall goal of Aim 4 is to enable the research community through ongoing technology development and education. By providing the framework for testing samples, training investigators, and sharing resources, the Core will accomplish its goals of high level support for musculoskeletal phenotyping and the sharing of standard operating procedures among the greater musculoskeletal research community.

密歇根综合肌肉骨骼健康核心中心 – 核心 D 项目概要 动物模型中肌肉骨骼表型的功能评估对于识别至关重要 疾病如何影响患者的综合健康和功能的机制 各种肌肉骨骼状况研究肌肉骨骼表型的能力。 广泛的规模需要大量的专业知识和高度专业化的生理学培训， 生物物理学和工程学，以及获得昂贵的、高分辨率的、最先进的技术 虽然偶尔可以使用单一方法的专业知识和设备。 在单个实验室中开发，开发这些方法可能成本高昂， 冗余，并且可能导致整个领域内非统一技术的扩散。 功能评估核心（核心 D）将动物、器官、组织和 在某些情况下，目前各个实验室使用的细胞水平表型分析能力 将密歇根大学整合为一个具有凝聚力且易于访问的核心服务 Core D 将整合各个实验室。 肌肉骨骼生物学和工程学的方法，包括最先进的技术 骨力学、肌肉功能和力学以及肌腱力学的测量。 这将通过基于假设的测试的实验优先顺序来实现， 协调跨核心实验，执行高精度表型研究，以及 核心 D 也将重点关注机构内部和外部研究人员之间的合作。 其产品可以增强当前研究社区的扩展能力 为进一步拓展核心中心的广度和深度，提出了四个目标： 核心将为目标 1 中的实验设计提供专业知识和指导，并访问 目标 2 借助最先进的技术和专家来量化动物、器官和 此外，在目标 3 中，核心将提供这些方法的培训。 提供结果解释的指导并为未来的研究提出建议。 最后，目标 4 的总体目标是使研究界能够通过持续的 通过提供测试样本的框架， 培训调查人员并共享资源，核心将实现其高水平目标 支持肌肉骨骼表型分析和标准操作程序共享 属于更大的肌肉骨骼研究界。