Visualsonics Vevo 3100 Ultrasound Imaging

Visualsonics Vevo 3100 超声成像

• 批准号: 10417498
• 负责人: Daniel E Michele
• 金额: $ 32.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10417498
• 关键词: 3-Dimensional; 4D Imaging; Aging; Anatomy; Aneurysm; Animal Model; Animals; Atherosclerosis; Blood Pressure; Blood Vessels; Cardiac; Cardiovascular Diseases; Color; Computer software; Disease; Disease model; Drug Delivery Systems; Electrocardiogram; Embryo; Equipment; Frequencies; Functional Imaging; Funding; Genetic Engineering; Heart; Image; Laboratory Animals; Longevity; Magnetic Resonance Imaging; Mechanics; Michigan; Modality; Mus; Neoplasms in Vascular Tissue; Oryctolagus cuniculus; Outcome; Pathogenesis; Phenotype; Physiological; Physiology; Preclinical Testing; Protocols documentation; Rattus; Request for Applications; Research Personnel; Resolution; Respiration; Rodent; Series; Services; Structure; Surgical Models; Telemetry; Three-Dimensional Imaging; Thrombosis; Time; Transducers; Tumor Volume; Ultrasonography; United States National Institutes of Health; Universities; Vascular Diseases; cost; end of life; experience; heart imaging; human disease; image reconstruction; imaging system; novel; novel therapeutics; operation; pre-clinical research; preclinical study; repaired; tool; ultrasound

Abstract Rodent animal models, including genetically engineered animals, surgical models, and naturally occurring disease models, remain the cornerstone of preclinical research, and are routinely used to study the mechanisms and pathogenesis of human disease and develop new therapies. High resolution ultrasound imaging is an essential phenotyping tool to be able to study internal animal anatomy and physiology non- invasively across the animal’s lifespan, during disease pathogenesis, and before or after preclinical testing of treatments. This SIG application requests funds to purchase a Visualsonics Vevo3100 Ultrasound Imaging System. This new imaging system will be essential to the operations of the Physiology Phenotyping Core, which has almost two decades of experience in providing ultrasound imaging to NIH funded investigators across the University of Michigan Campus. The new Vevo3100 will replace an aging Vevo 2100 that has reached its end of supported lifespan and routinely requires costly repairs. The Vevo3100 utilizes very high frequency linear array MX-series transducers that provide the highest resolution 2D and 3D imaging of small animal heart structure and function available, and also allow for quantitative, functional imaging of blood vessels and tumor volumes in animals as small as mouse embryos and up to large rats and rabbits. EKG and respiration gating and EKV Software provide unparalleled cine loop image reconstruction during the cardiac cycle at up to 10,000 frames per second, and enables a novel 4D Imaging Mode (3D + time) to capture 3D imaging of the heart during the cardiac cycle at near MRI levels of resolution but at a fraction of the time and cost. In addition, the VevoVasc imaging analysis and high-resolution color Doppler imaging provides a capability of analyzing consequences of vascular disease including aneurysms, atherosclerosis and the physiological effects of thrombosis. Importantly, the Vevo3100 will be incorporated into a robust, fully functional animal phenotyping core with expert ultrasound technical staff, an efficient recharge mechanism, standing animal protocols, procedural space, and laboratory animal support to ease access to novice or expert users across the university. The core also provides users access to surgical models of cardiovascular disease, telemetry recording, blood pressure, drug delivery and other phenotyping modalities which provide a pipeline for preclinical studies from disease models to experimental outcomes. For example, when combined with the blood pressure telemetry services available in the Physiology Phenotyping Core, VevoVasc allows for real-time non-invasive analysis of vascular wall mechanics. Overall, the Vevo3100 will allow the Physiology Phenotyping Core to provide new state of the art modes of functional ultrasound imaging to NIH funded users, and by replacing aging end-of-life equipment will allow the core to continue to provide ultrasound services to users into the next decade.

抽象的 啮齿动物模型，包括基因工程动物，手术模型和天然发生 疾病模型，仍然是临床前研究的基石，通常用于研究 人类疾病的机制和发病机理并发展了新的疗法。高分辨率超声 成像是能够研究内部动物解剖学和生理学的必不可少的表型工具 在动物的寿命，疾病发病机理期间以及临床前或之后的临床前检查期间， 治疗。此SIG申请要求资金购买Visualsonics VEVO3100超声成像 系统。这个新的成像系统对于生理表型核心的操作至关重要， 在为NIH资助的调查人员提供超声成像方面拥有将近二十年的经验 整个密歇根大学校园。新的VEVO3100将取代具有老化的VEVO 2100 达到了支撑寿命的结束，通常需要昂贵的维修。 VEVO3100使用很高 频率线性阵列MX系列传感器，可提供最高分辨率的2D和3D成像 动物心脏的结构和功能可用，还可以进行定量的血液功能成像 像小鼠胚胎一样小的动物中的血管和肿瘤体积，直至大鼠和兔子。自我和 呼吸门控和EKV软件在心脏期间提供无与伦比的Cine Loop图像重建 以每秒10,000帧的速度循环，并启用一种新颖的4D成像模式（3D +时间）捕获3D 心脏周期中心脏成像的分辨率接近MRI水平，但在很短的时间内 成本。此外，Vevovasc成像分析和高分辨率颜色多普勒成像提供了 分析血管疾病后果的能力，包括动脉瘤，动脉粥样硬化和 血栓形成的生理影响。重要的是，VEVO3100将被合并到坚固的，充分的 功能性动物表型核心具有专家超声技术人员，有效的充电机制， 常规动物方案，程序空间和实验室动物支持，以便轻松获得鼻子或专家 整个大学的用户。核心还为用户提供了对心血管疾病的手术模型的访问， 遥测记录，血压，药物输送和其他提供管道的表型方式 从疾病模型到实验结果的临床前研究。例如，与 生理表型核心可用的血压遥测服务，Vevovasc允许实时 血管壁力学的非侵入性分析。总体而言，VEVO3100将允许生理 表型核心为NIH资助的用户提供功能性超声成像的最新状态模式， 通过更换衰老终止设备，将使核心继续提供超声服务 用户进入未来十年。