Developing Pediatric Diabetes Investigators for the Future

培养未来的儿科糖尿病研究人员

• 批准号: 9188204
• 负责人: MARIAN J REWERS
• 金额: $ 39.51万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9188204
• 关键词: Adult; Area; Autoimmune Process; Autoimmunity; Basic Science; Behavioral Research; Biochemical; Biochemistry; Biology; Center for Translational Science Activities; Childhood; Clinical; Clinical Sciences; Colorado; Development; Developmental Biology; Diabetes Mellitus; Doctor of Philosophy; Drug Kinetics; Endocrinologist; Epidemiologic Studies; Epidemiology; Ethics; Functional disorder; Funding; Future; Genetic; Healthcare; Human; Human Genetics; Immune Tolerance; Immunology; Institutes; Insulin-Dependent Diabetes Mellitus; Investigation; Islet Cell; Master of Science; Medical; Medical Genetics; Medical Research; Medicine; Mentors; Molecular Biology; Molecular Genetics; Non-Insulin-Dependent Diabetes Mellitus; Pediatric Hospitals; Physicians; Population; Prevention; Public Health; Public Health Schools; Published Comment; Research; Research Institute; Research Methodology; Research Personnel; Research Training; Scientist; Technology; Training; Translational Research; United States National Institutes of Health; Universities; Work; Writing; career development; design; experience; faculty mentor; health economics; improved; medical schools; multidisciplinary; new technology; next generation; pediatric department; programs; statistics

SUMMARY ABSTRACT This application is a proposal for a career development program for pediatric endocrinologists, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), The University of Colorado School of Medicine (UC SOM) and the wider Anschutz Medical Campus (AMC). The proposal’s rationale is: 1) there is a critical nationwide shortage of pediatric endocrinologists trained and experienced in T1D and T2D research 2) diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric T1D and T2D to bring advances in diabetes research to the clinical arena. The BDC has an extensive and proven record in research training of young investigators. The BDC and AMC have a well-established network of investigators working in the epidemiology, new diabetes technology, immuno-biology, genetics, and molecular biology of T1D diabetes, as well as the abnormal pathophysiology of T2D. This network of experienced mentors is ideally suited to develop the next generation of pediatric endocrinologists into independent diabetes investigators in high impact T1D and T2D research. Areas of research focus within The BDC include islet cell development, genetics, molecular biology, immunology and the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and improved treatment, including new technology advancement, of T1D and T2D. These areas of research are urgently needed and have been identified as important to the national public health to improve diabetes treatment in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Sciences Institute (CCTSI), Pediatric and Adult Clinical Translational Research Centers, as well as a strong Masters of Science in Public Health and in Clinical Science and PhD programs in the Colorado School of Public Health (CSPH) and the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, and Children’s Hospital Colorado. The ability to provide excellent didactic coursework in statistics, epidemiology, research methods, ethics of human research, medical writing, biochemistry, pharmacokinetics, molecular and developmental biology, as well as human medical and molecular genetics through the CCTSI, the BDC and the CSPH combined with a strong mentoring faculty at the BDC, UCSOM and CSPH will allow us to provide the career development for pediatric endocrinologists producing independent investigators, capable of competing for funding in high quality diabetes research. Other programs within AMC that are supportive of this program include the Program in Human Genetics, the Immune Tolerance Network, the Autoimmune Prevention Center and Children’s Hospital Research Institute.

摘要摘要 该应用程序是针对儿科内分泌学家的职业发展计划的建议，旨在 在芭芭拉·戴维斯中心（BDC）的糖尿病研究中提供多学科培训 科罗拉多州医学院（UC SOM）和更广泛的Anschutz医疗校园（AMC）。提案的 理由是：1）全国范围内的小儿内分泌学家训练和经验不足 T1D和T2D研究2）糖尿病是小儿人群中越来越重大的医疗保健问题 从个人和健康经济学的角度来看，造成了毁灭性的后果3）目前的快速发展 糖尿病调查要求接受临床，生化，生化培训的物理科学家增加 流行病学和行为研究，以进行小儿T1D和 T2D将糖尿病研究进展带入临床领域。 BDC有广泛而验证的记录 在年轻研究人员的研究培训中。 BDC和AMC拥有一个完善的调查人员网络 从事流行病学，新糖尿病技术，免疫生物学，遗传学和分子生物学的工作 T1D糖尿病以及T2D的异常病理生理学。理想情况下，这个经验丰富的导师网络是 适合将下一代儿科内分泌学家发展成独立的糖尿病研究者 高影响力T1D和T2D研究。 BDC内的研究重点领域包括胰岛细胞的开发， 遗传学，分子生物学，免疫学和1型糖尿病的自身免疫性，预测和预防， 以及流行病学，预防和改进的治疗，包括T1D和T1D的新技术进步 T2D。迫切需要这些研究领域，并被认为对国家公众很重要 健康以改善美国的糖尿病治疗。 NIH支持的科罗拉多州增强了此应用程序 临床和转化科学研究所（CCTSI），儿科和成人临床翻译研究 中心，以及公共卫生和临床科学和博士计划的强大科学硕士 科罗拉多州公共卫生学院（CSPH）和CCTSI。此应用程序的支持 儿科，医学，CSPH和儿童医院科罗拉多州的部门。提供的能力 统计学，流行病学，研究方法，人类研究伦理学的出色教学课程，医学 写作，生物化学，药代动力学，分子和发育生物学以及人类医学和 通过CCTSI，BDC和CSPH通过CCTSI的分子遗传学结合了强烈的心理教师 BDC，UCSOM和CSPH将使我们能够为儿科内分泌学家提供职业发展 生产独立的研究人员，能够在高质量糖尿病研究中竞争资金。其他 该计划支持的AMC中的程序包括人类遗传学的程序，免疫 耐受性网络，自身免疫预防中心和儿童医院研究所。