CORONARY ARTERY CALCIFICATION IN TYPE I DIABETES

I 型糖尿病的冠状动脉钙化

• 批准号: 7604370
• 负责人: MARIAN J REWERS
• 金额: $ 17.5万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604370
• 关键词: Abdomen; Affect; Age; Age-Years; Area; Blood Pressure; Blood flow; Blood specimen; Cause of Death; Clinic Visits; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Diabetes Mellitus; Diagnosis; Dyes; Electrocardiogram; Electron Beam Tomography; Enrollment; Exercise; Fatty acid glycerol esters; Female; Funding; Future; General Population; Grant; Heart; Height; Hip region structure; Hispanics; Institution; Insulin; Insulin-Dependent Diabetes Mellitus; Left; Life; Measurement; Measures; Medical; Non-Invasive Cancer Detection; Patients; Persons; Population Distributions; Prevention program; Recruitment Activity; Research; Research Personnel; Resources; Rest; Risk; Sampling; Scanning; Schedule; Score; Screening procedure; Source; Stress Tests; Time; United States National Institutes of Health; Urine; Ventricular; Visit; Weight; Woman; calcification; coronary artery calcification; demographics; diabetic; male; men; mortality; non-diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Coronary artery disease (CAD) is the main cause of death in person with Type I diabetes. CAD also occurs earlier in life, affects women as often as men, and associated mortality is dramatically higher than that in the general population. This study will focus on non-invasive detection of CAD in high-risk persons with Type I diabetes for application in future screening and prevention programs. A sample of 800 patients with Type I diabetes and 600 non-diabetic controls will be recruited from the Denver Metro Area. The population distribution approximates the national and Denver area demographics for Type I diabetes. This study will recruit approximately 49% male and 51% female subjects; the expected ethnic distribution is 87% white, 7% Hispanic, 3% black, and 3% other. To enroll in the study, all subjects must be between 20 and 55 years of age. Patients with type I diabetes must have had diabetes for at least 10 years, must have been diagnosed before the age of 30, and must have had insulin within one year of being diagnosed. Both diabetic and non-diabetic patients will come for an initial clinic visit. At this visit, patients will be asked about their medical background. Measurements of weight, height, waist and hip circumference, and blood pressure will be taken. An electrocardiogram (ECG), a urine sample and blood sample will also be obtained. Diabetic patients will be asked to come in for another clinic visit in 3-years. Patients will also be scheduled for an electron-beam computed tomography scan (EBCT), which will look for coronary artery calcification in the heart. A scan of the abdomen will be done at the same time to measure the amount of fat in the abdomen. A coronary artery calcification (CAC) score and left ventricular area (LV area) will be calculated. CAC and large LV area may be early signs of CAD. All patients will be asked to have a repeat EBCT in 3 years. In a substudy, 50 high-risk diabetics (CAC score about 100), 30 low-risk diabetics (CAC score below 100), and 20 controls will come in for an additional visit. This visit will consist of a rest/stress test, which looks at heart blood flow at rest and during maximal exercise (using a treadmill). A contrast dye will be used in both cases to determine the blood flow in the heart. Patients with diabetes will be asked to repeat the rest/stress test in 3-years.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 冠状动脉疾病（CAD）是I型糖尿病的人死亡的主要原因。 CAD也发生在生活中的早期，影响女性的频率与男性一样频繁，并且相关的死亡率大大高于普通人群。 这项研究将着重于对I型糖尿病的高风险患者的CAD进行非侵入性检测，以在将来的筛查和预防计划中应用。 将从丹佛都会区招募800例I型糖尿病患者和600例非糖尿病控制患者的样本。 人口分布近似于I型糖尿病的国家和丹佛地区人口统计。这项研究将招募约49％的男性和51％的女性受试者；预期的种族分配为87％的白人，7％的西班牙裔，黑色3％和其他3％。 要参加研究，所有受试者都必须在20至55岁之间。 I型糖尿病患者必须患有至少10年的糖尿病，必须在30岁之前诊断出糖尿病，并且必须在被诊断出一年内接受胰岛素。 糖尿病患者和非糖尿病患者都将进行初次诊所。 在这次访问中，将询问患者有关他们的医疗背景。 重量，身高，腰部和臀部周长以及血压的测量。 心电图（ECG），还将获得尿液样本和血液样本。 糖尿病患者将被要求在三年内再次诊所访问。 还将安排患者进行电子束计算机断层扫描（EBCT），该扫描将在心脏中寻找冠状动脉钙化。 将同时进行腹部扫描以测量腹部脂肪的量。 将计算冠状动脉钙化（CAC）评分和左心室区域（LV区域）。 CAC和大型LV区域可能是CAD的早期迹象。 将要求所有患者在3年内重复EBCT。 在一种50个高危糖尿病患者（CAC得分约100）中，30个低风险糖尿病患者（CAC得分低于100），将有20个控制措施进行额外访问。 这次访问将包括休息/压力测试，该测试在休息时和最大运动过程中（使用跑步机）看着心血流动。 在两种情况下，都将使用一种对比染料来确定心脏的血流。 糖尿病患者将被要求在3年内重复其休息/压力测试。