DETERMINANTS OF INSULIN SENSITIVITY IN TYPE 1 DIABETES

1 型糖尿病胰岛素敏感性的决定因素

• 批准号: 7377862
• 负责人: MARIAN J REWERS
• 金额: $ 0.06万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377862
• 关键词: DETERMINANTS; INSULIN; SENSITIVITY; TYPE; DIABETES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to find out how type 1 diabetes affects the way the body uses glucose, which is the sugar that the body uses for energy. The hormone insulin is needed to bring glucose into the cells to be used for energy, and the amount of insulin that is needed to keep glucose levels in the blood normal is called 'insulin sensitivity'. Some people need more insulin than others to keep blood glucose levels normal. A test called the insulin clamp can be used to measure insulin sensitivity. This test is done by putting an IV, or small plastic tube, into the arm and infusing both glucose and insulin into the blood. A doctor tests the blood glucose levels every few minutes, and adjusts the amount of glucose that is being infused to keep the blood glucose level the same. The test takes a total of about 8 hours. For this research study, we plan to test insulin sensitivity in about 96 people, half with type 1 diabetes and half normal volunteers without diabetes. We will also draw blood samples for tests that we think might be related to how insulin sensitive a person is, including fats, hormones and immune system components in the blood. We will also measure height and weight, waist and hip girth, total body fat and abdominal fat volumes. The amount of fat in the abdomen will be measured using a CT scan. This test involves a very low dose of radiation, but this dose equals less than 1% of the radiation exposure allowed every year by the FDA. From this research study, we hope to learn what factors, such as waist girth, waist to hip ratio, and blood tests, can be used to predict insulin sensitivity. We are also interested in whether the same factors are related to insulin sensitivity in people with type 1 diabetes and in non-diabetic volunteers. In addition, we hope to learn how different levels of insulin affect the release of free fatty acids from stored fats in people with type 1 diabetes compared to non-diabetic volunteers.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是找出1型糖尿病如何影响人体使用葡萄糖的方式，该葡萄糖是人体为能量使用的糖。需要激素胰岛素将葡萄糖带入用于能量的细胞中，并且在血液中保持葡萄糖水平所需的胰岛素量称为“胰岛素敏感性”。有些人比其他人需要更多的胰岛素来保持血糖水平正常。称为胰岛素夹的测试可用于测量胰岛素敏感性。该测试是通过将IV或小塑料管放入手臂中，并将葡萄糖和胰岛素注入血液中来完成。医生每隔几分钟一次测试血糖水平，并调节正在注入的葡萄糖量以保持血糖水平相同。该测试总共需要大约8个小时。在这项研究中，我们计划在约96人中测试胰岛素敏感性，一半患有1型糖尿病和一半的正常志愿者，没有糖尿病。我们还将为我们认为可能与一个人敏感的胰岛素敏感有关的测试绘制血液样本，包括血液中的脂肪，激素和免疫系统成分。我们还将测量身高和体重，腰围和臀部的腰围，全体脂肪和腹部脂肪的体积。腹部中的脂肪量将使用CT扫描测量。该测试涉及非常低剂量的辐射，但是该剂量等于每年FDA允许的辐射暴露的1％。 从这项研究中，我们希望了解哪些因素，例如腰围，腰部与髋关节和血液检查，可用于预测胰岛素敏感性。我们还对1型糖尿病患者和非糖尿病志愿者的胰岛素敏感性是否与胰岛素敏感性有关。此外，我们希望学习与非糖尿病志愿者相比，不同水平的胰岛素如何影响1型糖尿病患者中储存脂肪的游离脂肪酸的释放。