Clinical Resource Core

临床资源核心

基本信息

批准号：
10392978
负责人：
MARIAN J REWERS
金额：
$ 14.44万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10392978
关键词：
Adolescent Adult Age Area Autoantibodies Autoimmunity Back Basic Science Beta Cell Bioinformatics Biological Biological Assay Biostatistical Methods Blood specimen Cardiovascular Diseases Cells Center for Translational Science Activities Child Childhood diabetes Clinic Clinical Clinical Data Clinical Research Collaborations Colorado Communication Complications of Diabetes Mellitus Computerized Medical Record Consult Core Facility Cross-Sectional Studies Data Data Linkages Data Management Resources Databases Development Diabetes Mellitus Diabetic Nephropathy Diagnostic Disease Economic Burden Equipment Faculty Faculty Recruitment Fostering Functional disorder Funding Gestational Diabetes Goals Grant Growth Health Hospitals Human Resources Hyperglycemia Improve Access Incidence Individual Infant Infrastructure Institution Insulin Resistance Insulin-Dependent Diabetes Mellitus Investigation Laboratories Logistics Longevity Longitudinal Studies Medical Medical center Metabolic dysfunction Molecular Analysis Morbidity - disease rate Mothers Non-Insulin-Dependent Diabetes Mellitus Outcome Participant Patient Recruitments Patients Pediatric Hospitals Persons Phenotype Physicians Plasma Population Process Productivity Protocols documentation Registries Research Research Design Research Infrastructure Research Personnel Resource Sharing Resources SECTM1 gene Sampling Scientist Serum Services Statistical Data Interpretation Talents Teacher Professional Development Techniques Technology Testing Tissue Sample Training Translational Research United States Department of Veterans Affairs United States National Institutes of Health Universities analytical tool bench-to-bedside translation biobank clinical care clinical center cystic fibrosis related diabetes data warehouse diabetes control diabetes risk diabetic eligible participant genetic analysis human leukocyte antigen testing improved interest metabolic phenotype mortality non-diabetic patient registry peripheral blood prevent programs recruit repository research facility sample collection type I and type II diabetes

项目摘要

CLINICAL RESOURCE CORE PROGRAM SUMMARY/ABSTRACT Diabetes represents a worldwide health crisis, with the incidence of both type 1 diabetes (T1D) and type 2 diabetes (T2D) steadily increasing. While autoimmunity is central to T1D, many key aspects of the disease process are shared by T1D and T2D, including beta cell dysfunction, hyperglycemia, metabolic dysfunction and insulin resistance. Complications of T1D and T2D also have many similarities, including cardiovascular disease (CVD) and diabetic kidney disease (DKD), both leading causes of morbidity and mortality. The University of Colorado Anschutz Medical Center (UC AMC) is among world leaders in clinical translational investigations into T1D and T2D across the lifespan, as well as in gestational diabetes (GDM) and cystic fibrosis-related diabetes (CFRD). Funding through the Diabetes Research Center (DRC) would capitalize on these existing strengths and catalyze the formation of an integrated comprehensive diabetes research program. The Clinical Resource Core (CR) of the UC Denver DRC stands at the interface of multiple institutions, programs and individuals, all of whom are working to prevent or ameliorate the devastating long term complications of diabetes and its high economic burden. The CR core would leverage the current clinical research facilities and equipment available at the Barbara Davis Center for Childhood Diabetes (BDC), UC AMC’s Clinical Translational Research Center (CTRC), The University of Colorado Hospital, Denver Veteran’s Administration Medical Center (VA) and Children’s Hospital Colorado. The DRC CR core would integrate diabetes research across these institutions through communication and distribution of the resources available, and create shared sample and data biobanks and a recruiting database of mothers, infants, children, adolescents and adults with diabetes, diabetes risk and controls. Such integration would accelerate progress and increase the quality of diabetes research, coalesce existing strengths and strategically focus faculty recruitment in areas of needed growth. DRC funding would also attract new talent at postgraduate and junior faculty levels and add unique components of infrastructure needed for discovery. Specifically, we will improve access and collaborations for recruiting subjects, tracking data and banking tissue samples from well-phenotyped participants with diabetes and control subjects across the lifespan; establish collections of samples from our well-characterized subjects and facilitate the ability of DRC users to perform assays from peripheral blood, serum and plasma utilizing state of the art techniques; improve provision of specialized diagnostic and analytic services.

临床资源核心程序摘要/摘要糖尿病代表着全球的健康危机，其中1型糖尿病（T1D）和2型事件糖尿病（T2D）稳步增加。尽管自身免疫性是T1D的核心，但疾病的许多关键方面过程由T1D和T2D共享，包括β细胞功能障碍，高血糖，代谢功能障碍和胰岛素抵抗。 T1D和T2D的并发症也有许多相似之处，包括心血管疾病（CVD）和糖尿病肾病（DKD），都是发病率和死亡率的主要原因。大学科罗拉多州安索斯医学中心（UC AMC）是临床转化调查中的世界领导者 T1D和T2D遍布整个寿命，以及妊娠糖尿病（GDM）和囊性纤维化相关糖尿病（CFRD）。通过糖尿病研究中心（DRC）的资金将利用这些现有优势并催化综合综合糖尿病研究计划的形成。 UC Denver DRC的临床资源核心（CR）位于多个机构的界面，程序和所有人都在努力预防或改善毁灭性的长期并发症糖尿病及其巨大的经济负担。 CR核心将利用当前的临床研究设施和 UC AMC的临床翻译研究中心（CTRC），科罗拉多大学医院，丹佛资深管理医疗中心（VA）和科罗拉多州儿童医院。 DRC CR核心将整合这些糖尿病研究通过通信和分配可用资源的机构，并创建共享样本和数据生物库和母亲，婴儿，儿童，青少年和成年人的招募数据库，糖尿病风险和控制。这种整合将加速进步并提高糖尿病的质量研究，合并现有的优势，并从战略上关注教师的招聘生长。刚果民主共和国的资金还将吸引研究生和初级教师级别的新人才，并添加发现所需的基础架构的独特组成部分。具体来说，我们将改善招聘主题，跟踪数据和银行组织的访问和协作来自整个寿命的糖尿病和对照受试者的良好表现的参与者的样本；已确立的来自我们特定的主题的样本收集，并促进了刚果民主共和国用户的能力利用艺术技术的状态的外周血，血清和血浆的测定；改善提供专门的诊断和分析服务。