Mount Sinai CHEAR Network Laboratory Hub

西奈山 CEAR 网络实验室中心

基本信息

批准号：
9351604
负责人：
Robert O Wright
金额：
$ 40万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9351604
关键词：
Address Affect Analytical Chemistry Archives Asthma Attention Deficit Disorder Behavioral Biochemical Biological Biological Assay Biological Markers Biological Sciences Charge Chemical Exposure Chemicals Child Child health care Childhood Chronic Disease Client Cohort Studies Communication Complex Computational Molecular Biology Computers Consultations Creativeness Data Data Set Development Developmental Biology Disease Dose Endocrine Disruptors Enrollment Ensure Environment Environmental Exposure Environmental Health Environmental Risk Factor Epidemiologic Studies Epidemiologist Exposure to Family Flame Retardants Funding Gene Expression Genetic Genetic Research Genetic study Genomics Goals Growth Health Immunologist Laboratories Life Life Cycle Stages Link Longevity Mass Spectrum Analysis Measures Metals Methodology Methods Mind Minerals Mission Modeling Molecular Nature Nutrient Nutritional status Obesity Occupations Perinatal Pesticides Phenotype Physiological Physiology Placenta Plant Roots Predisposition Pregnancy Procedures Protocols documentation Public Health Research Research Design Research Infrastructure Research Personnel Resources Risk Sampling Scientist Services Shipping Ships Stress Structure Technology Time Tobacco Tooth structure Toxicokinetics United States United States National Institutes of Health Untranslated RNA Vitamins Work base biomarker discovery case control cohort design disability disorder risk epigenomics experience fetal flexibility gene environment interaction immune function innovation interest medical schools meetings multidisciplinary novel novel marker operation outreach pediatrician programs prospective response response biomarker sample collection social social stress stressor toxicant

项目摘要

DESCRIPTION (provided by applicant): The Icahn School of Medicine at Mount Sinai will leverage our research expertise in children's environmental health and the Frank Lautenberg Laboratory for Environmental Health Sciences to form a new Children's Health Exposure Analysis Resource (CHEAR) Laboratory Network Hub. We will measure environmental exposures, both targeted and untargeted, across pregnancy and childhood to help NIH-funded researchers determine how the environment affects child health, development and risk of disease across the life span. Our team will develop new methodologies to objectively reconstruct past chemical exposures, allowing researchers to study susceptibility windows as they relate to child health. Four laboratory resources/cores will be established to achieve these goals; 1) a targeted analysis resource that will analyze common environmental exposure biomarkers (metals, pesticides, flame retardants, endocrine disrupting chemicals, tobacco metabolites, vitamins, nutritional status, minerals, and other organic compounds) using state-of-the-art analytical methodologies; 2) an untargeted analysis resource using advanced technologies such as time-of- flight mass spectrometry to discover the chemicals, metabolites and other biomarkers that are associated with child health and disease; 3) a biological response indicators resource that will link environmental exposures to changes in immune function, epigenomic marks, gene expression, noncoding RNA and other response biomarkers; and 4) we will establish a developmental core that will create novel methods to measure current and past chemical exposures in new biological matrices (e.g. teeth, placenta), develop new assays to study emerging toxicants, and develop new methods to assess the body's response to exposure. An Administrative Core will be established to coordinate planning and communication externally with the CHEAR Coordinating Center, the CHEAR Data Center and the other CHEAR Network Laboratory Hubs. Internally, the Administration Core will integrate work among our Resources/Cores to streamline and prioritize job orders, assess assay needs, promote and disseminate new assays as they are developed, harmonize protocols and QA/QC procedures and coordinate day to day operations. This laboratory Hub will advise applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols and sample shipping specifications. Both analysis and interpretation of Lab Hub-generated data will be supported in cooperation with the Data Center; and if necessary, we will outreach to outside laboratories with analytic capabilities/expertise that do not reside in our Lab Hub. In conclusion, this proposal links highly experienced environmental health scientists with pediatricians, toxicologists, stress researchers, chemists, exposure scientists, epidemiologists, computer scientists, immunologists, and epigeneticists to build the infrastructure and capacity to objectively measure child environments.

描述（由申请人提供）：西奈山伊坎医学院将利用我们在儿童环境健康方面的研究专业知识和 Frank Lautenberg 环境健康科学实验室，组建一个新的儿童健康暴露分析资源 (CHEAR) 实验室网络中心。将测量整个怀孕期和儿童期的有针对性和无针对性的环境暴露，以帮助 NIH 资助的研究人员确定环境如何影响儿童的健康、发育和整个生命周期的疾病风险。我们的团队将开发新的方法。客观地重建过去的化学品暴露情况，使研究人员能够研究与儿童健康相关的易感性窗口，以实现这些目标；1）有针对性的分析资源，用于分析常见的环境生物标志物暴露情况（金属、农药）。 2）使用先进技术的非目标分析资源，例如作为飞行时间质谱法，用于发现与儿童健康和疾病相关的化学物质、代谢物和其他生物标志物；3) 生物反应指标资源，将环境暴露与免疫功能、表观基因组标记、基因表达的变化联系起来，非编码 RNA 和其他反应生物标志物；4) 我们将建立一个开发核心，创建新方法来测量新生物基质（例如牙齿、胎盘）中当前和过去的化学暴露，开发新的测定方法来研究新兴的将建立一个管理核心，以协调外部与 CEAR 协调中心、CEAR 数据中心和其他 CEAR 网络实验室中心的沟通。整合我们的资源/核心之间的工作，以简化和优先考虑工作订单、评估需求、推广和传播新检测方法的开发、协调协议和 QA/QC 程序并协调该实验室的日常运营。中心将与数据中心合作，为申请人提供有关样品要求、样品质量、结果解释、样品采集、存储协议和样品运输规格的建议；与我们实验室中心不具备的分析能力/专业知识的外部实验室进行联系。该提案将经验丰富的环境健康科学家与儿科医生、毒理学家、压力研究人员、化学家、暴露科学家、流行病学家、计算机科学家、免疫学家和表观遗传学家联系起来，以建立客观测量儿童环境的基础设施和能力。