The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) Cohort
肥胖、生长、环境和社会压力(PROGRESS)队列的规划研究
基本信息
- 批准号:9761855
- 负责人:
- 金额:$ 34.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-30 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:7 year oldAddressAdolescenceAffectAgeAir PollutionBackBehavioralBig DataBiologicalBiological AssayBiological MarkersBiological ModelsBiometryBirthChemical ExposureChemicalsChildChild DevelopmentChild HealthChildhoodCitiesCognitiveCollaborationsComplexConceptionsDataData CollectionData DiscoveryData LinkagesData ScienceData SetDentalDevelopmentDiseaseDoseEducational MaterialsEnrollmentEnvironmentEnvironmental ExposureEnvironmental HealthEpidemiologistExposure toFamilyFosteringFundingFutureGeneticGenomicsGeographic Information SystemsGoalsGrantGreen spaceGrowthHealthHumanIncubatorsInfantInfrastructureInstitutesInstitutional Review BoardsInternationalInvestmentsLaboratoriesLearning DisabilitiesLifeLife Cycle StagesLinkLongevityMaintenanceMeasurableMeasuresMethodologyMethodsMexicoMissionModelingMonoclonal Antibody R24MothersNational Institute of Environmental Health SciencesNatureNeurocognitiveNeurologicNutritionalObesityOutcomeParticipantPathway interactionsPerinatalPhenotypePositioning AttributePredispositionPregnancyProcessProtocols documentationPsychologistPubertyPublic HealthResearchResearch PersonnelResourcesSample SizeScienceScientistSocietiesStatistical Data InterpretationStatistical MethodsStressTemperatureTestingTimeTooth structureUnited States National Institutes of HealthUniversitiesWorkbasebiobankbuilt environmentcognitive testingcohortdesignearly adolescenceenvironmental chemicalexperiencefetalfollow-upgene environment interactionhealth dataimprovedinnovationmolecular markerneurobehaviorneurodevelopmentnext generationnovelnutritionparticipant retentionpediatricianphenotypic datapostnatalprenatalprenatal exposureprogramsprospectiveprotocol developmentremote sensingresponsesocialsocial mediasocial stressstressorsuccesstrendwalkabilityweb site
项目摘要
PROJECT SUMMARY/ABSTRACT
Mount Sinai will partner with the National Institute of Public Health, Mexico and Columbia University to
continue to follow 700 children at ages 8-11 in the PROGRESS birth cohort established in 2006 in Mexico City
to study perinatal programming of child development. PROGRESS is a state of the art birth cohort that has
developed innovative new methods to estimate past exposure to environmental chemicals, both with
biomarkers of internal dose (e.g. teeth based chemical assays) and with geospatial modeling of the external
environment via remote sensing(e.g. air pollution, green space etc). This application will also leverage Mount
Sinai's recently established Environmental Health Sciences Laboratory to build upon our internationally
recognized research expertise in children's environmental health. Our mission is to measure environmental
exposures across pregnancy and childhood to determine how these factors affect neurodevelopment and
growth. We are especially excited to extend this work in PROGRESS as our overarching goal is to prepare the
cohort the coming era of exposomic research. In this R24 we will test methods for data harmonization that will
be critical to future work. By piloting pooling methods with researchers with similarly designed cohorts we set
the stage to build new consortia to study the health impacts of chemicals, nutrition, social factors, and the
gene-environment interactions that underlie childhood disease. Our team has all the requisite expertise in
exposure science, biostatistics, child health phenotyping and in cohort management. We have already
developed several new methodologies to objectively reconstruct past chemical exposures that precisely
estimate exposure timing, allowing researchers to identify susceptibility windows as they relate to child health.
Over the last 10 years, PROGRESS has supported 16 NIH grants led by 10 different researchers (including 7
K awardees), demonstrating our ability to serve as an incubator for the next generation of Environmental
Health scientists. To accommodate divergent research needs among this group, the PI has formed the
equivalent of an Administrative Core that will plan, organize, streamline and prioritize field work by coordinating
the associated administrative work (IRB, protocol development, finances etc). We will also develop new
programs to assess participant needs in order to improve retention, adapt to advances in social media, assess
new health outcomes and exposures, and implement new exposure/response assays as we prepare our cohort
for future big data consortia research. This proposal links highly experienced environmental health scientists
with statisticians, social epidemiologists, child psychologists, chemists, pediatricians, and epigeneticists to
support the infrastructure of a highly functional, state of the longitudinal birth cohort that objectively measures
the human environments that program child health. We will follow PROGRESS children up to the onset of
puberty, linking fetal exposures to health changes inherent to this critical life stage. Finally, despite our many
successes, without this R24, field work will cease and this application is critical to our future success.
项目摘要/摘要
西奈山将与国家公共卫生研究所,墨西哥和哥伦比亚大学合作
继续关注2006年在墨西哥城成立的8-11岁的8-11岁儿童
研究儿童发育的围产期编程。进度是一种艺术出生队列的状态
开发了创新的新方法来估计过去对环境化学物质的接触,均与
内剂量的生物标志物(例如,基于牙齿的化学测定)和外部地理空间建模
环境通过遥感(例如空气污染,绿色空间等)。该应用程序还将利用安装座
西奈最近建立的环境健康科学实验室,以我们的国际为基础
公认的儿童环境健康研究专业知识。我们的任务是衡量环境
在怀孕和童年期间暴露,以确定这些因素如何影响神经发育和
生长。我们特别兴奋地扩展了这项工作,因为我们的总体目标是准备
同龄人即将到来的外汇研究时代。在此R24中,我们将测试方法的数据协调方法
对未来的工作至关重要。通过与具有类似设计的队列的研究人员驾驶合并方法,我们设置了
建立新财团来研究化学物质,营养,社会因素和
基因环境相互作用是儿童疾病的基础。我们的团队拥有所有必要的专业知识
暴露科学,生物统计学,儿童健康表型和队列管理。我们已经
开发了几种新方法来客观地重建过去的化学暴露
估计暴露时间,使研究人员可以在与儿童健康相关的情况下识别易感性窗口。
在过去的十年中,进步支持了10位不同研究人员领导的16份NIH赠款(包括7个
k获奖者),证明我们有能力作为下一代环境的孵化器
健康科学家。为了满足该小组之间不同的研究需求,PI形成了
相当于将通过协调来计划,组织,简化和优先考虑现场工作的行政核心
相关的行政工作(IRB,协议开发,财务等)。我们还将开发新的
评估参与者需求以提高保留率,适应社交媒体的进步,评估的计划
我们准备队列时,新的健康成果和暴露,并实施新的暴露/响应分析
用于未来的大数据联盟研究。该提案链接经验丰富的环境健康科学家
与统计学家,社会流行病学家,儿童心理学家,化学家,儿科医生和表观遗传学家一起
支持高度功能的纵向出生队列的基础设施,该状态客观地衡量
对儿童健康进行编程的人类环境。我们将跟随进步的孩子到发作
青春期,将胎儿暴露与这个关键生命阶段固有的健康变化联系起来。最后,尽管我们有很多
如果没有这项R24,成功将停止现场工作,并且此应用对我们未来的成功至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Robert O Wright', 18)}}的其他基金
Mount Sinai HHEAR Network Targeted Lab Hub
西奈山 HHEAR 网络目标实验室中心
- 批准号:
10875017 - 财政年份:2023
- 资助金额:
$ 34.43万 - 项目类别:
Stress-Chemical Interactions and Neurobehavior in School Age Children
学龄儿童的应激化学相互作用和神经行为
- 批准号:
10337782 - 财政年份:2021
- 资助金额:
$ 34.43万 - 项目类别:
Associations among in utero exposure to metals/metal mixtures,stress/stress mixtures, and internalizing problems in early childhood
子宫内接触金属/金属混合物、压力/压力混合物与幼儿期内化问题之间的关联
- 批准号:
10412666 - 财政年份:2016
- 资助金额:
$ 34.43万 - 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
- 批准号:
10675379 - 财政年份:2016
- 资助金额:
$ 34.43万 - 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
- 批准号:
10018530 - 财政年份:2016
- 资助金额:
$ 34.43万 - 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
- 批准号:
10239019 - 财政年份:2016
- 资助金额:
$ 34.43万 - 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
- 批准号:
10469680 - 财政年份:2016
- 资助金额:
$ 34.43万 - 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
- 批准号:
9355705 - 财政年份:2016
- 资助金额:
$ 34.43万 - 项目类别:
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