Dynamic Links Between Risk Factors, Substance Use, and Consequences: Ages 18-35

风险因素、药物使用和后果之间的动态联系：18-35 岁

• 批准号: 9023522
• 负责人: Megan E. Patrick
• 金额: $ 35.33万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9023522
• 关键词: Accounting; Acute; Address; Adolescent; Adult; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Behavior; Behavioral; Birth; Chronic; Cognitive; Collaborations; Confounding Factors (Epidemiology); Data; Development; Drug usage; Drug user; Employment; Epidemiology; Ethnic Origin; Etiology; Frequencies; Future; Gender; Health; Health Status; Individual; Intervention; Left; Life Cycle Stages; Link; Long-Term Effects; Marijuana; Marriage; Mediating; Mental Health; Methodology; Methods; Modeling; Monitor; Outcome; Parenting Education; Pathway interactions; Pharmaceutical Preparations; Policies; Population; Public Health; Race; Research; Research Personnel; Resources; Risk; Risk Behaviors; Risk Factors; Role; Sampling; Social Environment; Statistical Methods; Subgroup; Substance Use Disorder; Symptoms; Techniques; Testing; Time; Tobacco; United States National Institutes of Health; Variant; Weight; base; behavior change; binge drinking; cohort; college; demographics; follow-up; innovation; interest; intervention program; marijuana use; person centered; sex risk; theories; therapy development; twelfth grade; young adult

DESCRIPTION (provided by applicant): Substance use has acute and chronic detrimental impacts on public health. However, risk for use is not conferred equally across the population, the life course, or birth cohorts. Central questions about when and for whom risk factors are most important in contributing to substance use (tobacco, alcohol, marijuana, and other drug use) in young adulthood (YA) remain unanswered, including the extent to which substance use in YA leads to adult health consequences such as substance use disorders (SUDs), sexual risk behaviors, and physical/mental health deficits. Based on a life course perspective, this project will move the field toward examining developmental changes in the salience of risk factors across the life course and toward documenting the mechanisms through which long-term substance use consequences emerge. We will use national panel data from 38 high school senior year cohorts (1976 to 2013), with specific emphasis on 20 cohorts of individuals with longitudinal data across ages 18 to 35 (N~24,000) from Monitoring the Future (MTF) to examine significant unanswered questions regarding adolescent and YA substance use behaviors and adult health outcomes. Leading-edge statistical methods applied to MTF data will be used to model the dynamic associations between risk factors and risk behaviors across YA, and the extent to which these behaviors predict adult health consequences. Aim 1 will examine questions regarding developmental changes in the epidemiology and etiology of substance use across ages, cohorts, social role statuses, and demographic subgroups. Questions include the extent to which the links between cognitive/attitudinal risk factors and substance use behaviors change with age. Aim 2 will examine the long-term consequences of YA substance use on the acquisition and timing of social role statuses and health into adulthood. For example, we will examine the extent to which social roles mediate the effect of YA substance use on adult health consequences. Aim 3 will focus on disseminating new and advanced methodological techniques for examining risk factors, behaviors, and consequences to public health researchers. Results will advance our understanding of substance use behaviors with critical health impacts, and will inform the development of interventions that take into account individual behaviors, risk factors, and social roles to find strategies for reducing the negative consequences of drug use in young adulthood.

描述（由申请人提供）：物质使用对公共卫生有急性和慢性有害影响。但是，在整个人群，生命过程或出生队列中，使用风险并未同样赋予。关于何时何时及其谁在成年后造成物质使用（烟草，酒精，大麻和其他吸毒）最重要的危险因素（YA）（YA）仍未得到解决，包括YA中的药物使用导致成人健康后果（例如药物使用障碍（SUDS），性风险行为），性风险行为和身体健康健康和身体健康的健康，以及健康的范围。根据生活课程的观点，该项目将迈向研究整个生命过程中风险因素显着性的发展变化，并朝着记录长期出现后果后果的机制。我们将使用来自38年高中队列（1976年至2013年）的国家小组数据，具体强调了20名在18至35岁至35岁（N〜24,000）的人群中，监测未来（MTF），以检查有关青少年和YA药物使用行为和成人健康的重要问题。应用于MTF数据的领先统计方法将用于模拟YA风险因素和风险行为之间的动态关联，以及这些行为预测成人健康后果的程度。 AIM 1将研究有关跨年龄，人群，社会角色地位和人口亚组的流行病学和病因的发展变化的问题。问题包括认知/态度危险因素与物质使用行为之间的联系程度随着年龄的增长而变化。 AIM 2将研究YA物质使用对成年期社会角色地位和健康的收购和时机的长期后果。例如，我们将研究社会角色在多大程度上介导YA物质使用对成人健康后果的影响。 AIM 3将着重于传播新的和先进的方法论技术，以检查对公共卫生研究人员的风险因素，行为和后果。结果将提高我们对具有关键健康影响的物质使用行为的理解，并将为考虑个人行为，危险因素和社会角色的干预措施的发展提供信息，以找到减少成年后吸毒的负面影响的策略。