1/2 NCCU-DUKE Cancer Disparities Translational Research Partnership

1/2 NCCU-DUKE 癌症差异转化研究合作伙伴关系

基本信息

批准号：
9246378
负责人：
STEVEN R PATIERNO
金额：
$ 23.49万
依托单位：
NORTH CAROLINA CENTRAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-20 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9246378
关键词：
Academic Medical Centers Address Advanced Malignant Neoplasm Advisory Committees African American Attention Bioinformatics Biological Sciences Biomanufacturing Biomedical Research Cancer Center Cancer Control Cancer Patient Clinic Clinical Clinical Trials Collaborations Collection Communities Community Health Education Community Outreach Complement Comprehensive Cancer Center Contracts Detection Development Disease Doctor of Philosophy Education Education and Outreach Educational workshop Evaluation Faculty Fostering Genomics Historically Black Colleges and Universities Human Human Subject Research Institutes Institution Intellectual Property Joints Leadership Malignant Neoplasms Malignant neoplasm of prostate Medical center Mentors Minority Minority Graduate Student Modeling Molecular NCI-Designated Cancer Center North Carolina Outcome Pathway interactions Pharmacologic Substance Phase Pilot Projects Population Postdoctoral Fellow Prevention Procedures Process Program Evaluation Prostate Recording of previous events Recruitment Activity Research Research Infrastructure Research Institute Research Personnel Research Project Grants Research Training Resource Sharing Resources STEM field Science Staging Strategic Planning System Technology Training Training Programs Training and Education Translational Research Translational Research Working Group Underrepresented Minority Underrepresented Students Underserved Population United States National Institutes of Health Universities Woman Work anticancer research base cancer care cancer health disparity cancer prevention cancer therapy career development computational chemistry data sharing direct application drug development drug discovery education research graduate student health disparity health equity inflammatory breast cancer infrastructure development innovation longitudinal database meetings member men next generation organizational structure programs racial diversity student training symposium tumor undergraduate student underrepresented minority student underserved minority

项目摘要

ABSTRACT The North Carolina Central University (NCCU) – DUKE Cancer Disparities Translational Research Partnership (NCCU-DCI-CDTRP) is focused on developing infrastructure for translational cancer health disparities research, education and training and on performing two such pilot research projects, focusing on the molecular aspects underlying the increased lethality of prostate and inflammatory breast cancer in African Americans, with direct application to prevention, detection and treatment. This Program is built on the long-standing relationship between the two Durham-based Institutions, less than four miles apart. NCCU is an Institution Serving Underserved health disparity Populations and underrepresented Students (ISUPS), affiliated with the 17-member University of North Carolina system and the Duke Cancer Institute (DCI) is an NCI-designated Comprehensive Cancer Center (CC). The Partnership, focusing on translational cancer health disparities research and education and training of graduate students, postdoctoral fellows and early stage investigators (ESIs) in this field, which is described by the NIH Translational Research Working Group, will distinguish itself with synergistic complementarity to an existing U54 between NCCU and UNC, which focuses on sociocultural disparities research and education and training of undergraduate students. To this Partnership, the Biomanufacturing Research Institute and Technology Enterprise (BRITE) faculty at NCCU will bring a unique perspective from an ISUPS, expertise in pharmaceuticals, drug discovery and development, as well as existing extensive health disparities education and training programs. The CC, DCI, will bring a unique distinguishing focus on biospecimen collection, correlative science in the context of clinical trials, development of racially diverse cancer patient-derived models and programs addressing minority accrual to treatment and biospecimen collection clinical trials. Development of the Partnership occurred and is continuing around planning and priority-setting stages, including selection of co-developed, collaborative pilot research projects and creation of a fully integrated, bi-directional, mutually beneficial Cancer Research Education Program (CREP). The Implementation stage will launch the pilot research projects, utilizing nearly 25 Shared Resources between NCCU and Duke, the CREP and the engagement of underserved minority populations across the region and state, with complementary existing programming mutually emanating from NCCU, which directly serves a minority community, and DCI’s Office of Health Equity and Disparities. The Partnership will be led by an integrated Administrative Core of senior investigators who will serve as mentors to ESIs, rigorously addressing career development, to postdoctoral fellows and to graduate students and will include an extensive Evaluation Program for tracking impact and outcomes. The Partnership will be guided by an Internal Advisory Committee (IAC), an External Advisory Committee (EAC), focused solely on scientific guidance, and a Community Advisory Board (CAB).

抽象的北卡罗来纳州中央大学（NCCU） - 杜克癌症差异转化研究伙伴关系（NCCU-DCI-CDTRP）专注于开发用于转化癌症健康分布的基础设施研究，教育和培训以及执行两个这样的试点研究项目，重点是分子非洲裔美国人的前列腺和炎症性乳腺癌致死率增加的基础直接应用预防，检测和治疗。该程序建立在长期以来的两个基于达勒姆的机构之间的关系，相距不到四英里。 NCCU是一个机构为服务不足的健康差异人群和代表性不足的学生（ISUP）提供服务由17名成员的北卡罗来纳大学系统和杜克癌症研究所（DCI）是NCI指定的综合癌症中心（CC）。伙伴关系，重点是翻译的癌症健康分布研究，教育和培训研究生，博士后研究员和早期调查员 NIH转化研究工作组描述的（ESI）将会区分自己与NCCU和UNC之间的现有U54的协同互补性，重点是社会文化本科生的差异研究和教育和培训。对于这种伙伴关系， NCCU的生物制造研究所和技术企业（BRITE）教师将带来独特的 ISUP的观点，药品专业知识，药物发现和开发以及现有广泛的健康分配教育和培训计划。 CC，DCI将带来独特的区别专注于临床试验的背景下的生物传播收集，相关科学，种族发展潜水癌症患者衍生的模型和计划，以解决少数群体的治疗准确性和 Biospecimen Collection临床试验。伙伴关系的发展发生并正在继续计划和优先设定阶段，包括选择共同开发的协作试点研究项目并创建完全整合，双向，互惠互利的癌症研究教育计划（Crep）。实施阶段将使用近25个共享资源启动试点研究项目在NCCU和DUKE之间，CREP和服务不足的少数群体的参与地区和州，由NCCU直接从NCCU散发的现有编程为少数族裔社区和DCI的卫生公平与差异办公室服务。合伙企业将由高级调查员的综合行政核心，将担任ESI的导师针对职业发展，向博士后研究员和研究生致敬，并将包括广泛的跟踪影响和结果的评估计划。合作伙伴关系将以内部咨询为指导外部咨询委员会（EAC）委员会（IAC）仅着眼于科学指导，社区顾问委员会（CAB）。