1/2 NCCU-DUKE Cancer Disparities Translational Research Partnership

1/2 NCCU-DUKE 癌症差异转化研究合作伙伴关系

基本信息

批准号：
9763335
负责人：
STEVEN R PATIERNO
金额：
$ 21.44万
依托单位：
NORTH CAROLINA CENTRAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-20 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763335
关键词：
Academic Medical Centers Address Advanced Malignant Neoplasm Advisory Committees African American Attention Bioinformatics Biological Sciences Biomanufacturing Biomedical Research Cancer Center Cancer Control Cancer Patient Clinic Clinical Clinical Trials Collaborations Collection Communities Community Outreach Complement Comprehensive Cancer Center Contracts Detection Development Disease Doctor of Philosophy Education and Outreach Educational workshop Evaluation Faculty Fostering Genomics Human Human Subject Research Infrastructure Institutes Institution Intellectual Property Joints Leadership Malignant Neoplasms Malignant neoplasm of prostate Medical center Mentors Minority Minority Graduate Student Modeling Molecular NCI-Designated Cancer Center North Carolina Outcome Pathway interactions Pharmacologic Substance Phase Pilot Projects Population Postdoctoral Fellow Prevention Procedures Process Program Evaluation Prostate Recording of previous events Research Research Institute Research Personnel Research Project Grants Research Training Resource Sharing Resources STEM field Science Strategic Planning System Technology Telephone Training Training Programs Training and Education Translational Research Translational Research Working Group Underrepresented Minority Underrepresented Students Underserved Population United States National Institutes of Health Universities Woman Work anticancer research base cancer care cancer health disparity cancer prevention cancer therapy career development computational chemistry data sharing direct application drug development drug discovery education research graduate student health disparity health equity inflammatory breast cancer infrastructure development innovation longitudinal database meetings member men minority communities next generation organizational structure programs racial diversity recruit student training symposium translational research program tumor undergraduate student underrepresented minority student underserved minority

项目摘要

ABSTRACT The North Carolina Central University (NCCU) – DUKE Cancer Disparities Translational Research Partnership (NCCU-DCI-CDTRP) is focused on developing infrastructure for translational cancer health disparities research, education and training and on performing two such pilot research projects, focusing on the molecular aspects underlying the increased lethality of prostate and inflammatory breast cancer in African Americans, with direct application to prevention, detection and treatment. This Program is built on the long-standing relationship between the two Durham-based Institutions, less than four miles apart. NCCU is an Institution Serving Underserved health disparity Populations and underrepresented Students (ISUPS), affiliated with the 17-member University of North Carolina system and the Duke Cancer Institute (DCI) is an NCI-designated Comprehensive Cancer Center (CC). The Partnership, focusing on translational cancer health disparities research and education and training of graduate students, postdoctoral fellows and early stage investigators (ESIs) in this field, which is described by the NIH Translational Research Working Group, will distinguish itself with synergistic complementarity to an existing U54 between NCCU and UNC, which focuses on sociocultural disparities research and education and training of undergraduate students. To this Partnership, the Biomanufacturing Research Institute and Technology Enterprise (BRITE) faculty at NCCU will bring a unique perspective from an ISUPS, expertise in pharmaceuticals, drug discovery and development, as well as existing extensive health disparities education and training programs. The CC, DCI, will bring a unique distinguishing focus on biospecimen collection, correlative science in the context of clinical trials, development of racially diverse cancer patient-derived models and programs addressing minority accrual to treatment and biospecimen collection clinical trials. Development of the Partnership occurred and is continuing around planning and priority-setting stages, including selection of co-developed, collaborative pilot research projects and creation of a fully integrated, bi-directional, mutually beneficial Cancer Research Education Program (CREP). The Implementation stage will launch the pilot research projects, utilizing nearly 25 Shared Resources between NCCU and Duke, the CREP and the engagement of underserved minority populations across the region and state, with complementary existing programming mutually emanating from NCCU, which directly serves a minority community, and DCI’s Office of Health Equity and Disparities. The Partnership will be led by an integrated Administrative Core of senior investigators who will serve as mentors to ESIs, rigorously addressing career development, to postdoctoral fellows and to graduate students and will include an extensive Evaluation Program for tracking impact and outcomes. The Partnership will be guided by an Internal Advisory Committee (IAC), an External Advisory Committee (EAC), focused solely on scientific guidance, and a Community Advisory Board (CAB).

抽象的北卡罗莱纳中央大学 (NCCU) – DUKE 癌症差异转化研究合作伙伴关系 (NCCU-DCI-CDTRP) 致力于开发转化癌症健康差异的基础设施研究、教育和培训，以及开展两个这样的试点研究项目，重点是分子非裔美国人前列腺癌和炎性乳腺癌致死率增加的潜在因素，直接应用于预防、检测和治疗该计划建立在长期存在的基础上。位于达勒姆的两个机构之间的关系，相距不到四英里，是一个机构。服务于服务不足的健康差距人群和代表性不足的学生 (ISUPS)，隶属于北卡罗来纳大学系统由 17 名成员组成，杜克癌症研究所 (DCI) 是 NCI 指定的综合癌症中心 (CC) 合作伙伴关系，重点关注转化癌症健康差异。研究生、博士后研究员和早期研究人员的研究、教育和培训 NIH 转化研究工作组描述的这一领域的 (ESI) 将脱颖而出与 NCCU 和 UNC 之间现有的 U54 具有协同互补性，重点关注社会文化本科生的研究、教育和培训方面的差异。国立政治大学生物制造研究所和技术企业（BRITE）教师将带来独特的从 ISUPS 的角度来看，制药、药物发现和开发方面的专业知识以及现有的广泛的健康差异教育和培训计划将带来独特的 CC、DCI。专注于生物样本收集、临床试验背景下的相关科学、种族发展多样化的癌症患者衍生模型和计划，解决少数人的治疗收益和生物样本收集临床试验的发展已经发生并仍在继续。规划和优先事项设定阶段，包括选择共同开发的合作试点研究项目并创建一个完全整合、双向、互利的癌症研究教育计划 (CREP) 实施阶段将利用近 25 个共享资源启动试点研究项目。 NCCU 和杜克大学之间的合作、CREP 以及整个地区服务不足的少数民族人口的参与 NCCU 提供互补的现有规划，直接该合作伙伴关系为少数族裔社区服务，DCI 的健康公平和差异办公室将由该办公室领导。由高级研究人员组成的综合行政核心，他们将作为 ESI 的导师，严格执行解决博士后研究员和研究生的职业发展问题，并将包括广泛的跟踪影响和成果的评估计划将由内部咨询指导。委员会 (IAC)、外部咨询委员会 (EAC)，仅专注于科学指导，以及社区咨询委员会 (CAB)。