Duke Cancer Health Disparities P20 SPORE

杜克大学癌症健康差异 P20 SPORE

• 批准号: 10263341
• 负责人: STEVEN R PATIERNO
• 金额: $ 106.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263341
• 关键词: Address; African; African American; Age; Alternative Splicing; Antibody Response; Area; Basic Science; Bioinformatics; Biological; Biology; Biometry; Caring; Catchment Area; Clinical; Collaborations; Communication; Communities; Complex; Data; Development; Diagnosis; Disease; Doctor of Philosophy; Early Diagnosis; Ensure; Environment; Environmental Health; Epidemiology; European; Evaluation; Event; Exhibits; Feeds; Foundations; Funding; Future; Gastric Intraepithelial Neoplasia; Gastric Metaplasia; Genotype; Goals; Health; Health system; Helicobacter pylori; Immune response; Incidence; Infrastructure; Institutes; Intercept; Leadership; Life Style; Malignant Neoplasms; Malignant neoplasm of lung; Non-Small-Cell Lung Carcinoma; Not Hispanic or Latino; Outcome; Pathology; Patients; Pilot Projects; Population; Preparation; Prevention; Prevention strategy; Program Research Project Grants; RNA Splicing; Race; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Scientist; Seeds; Services; Smoking Status; Specimen; Structure; Subgroup; Therapeutic; Therapeutic Intervention; Translating; Translational Research; Virulence Factors; Work; base; biobank; cancer care; cancer health disparity; clinical translation; clinically relevant; cohort; disparity reduction; gastric carcinogenesis; health equity; improved; in vitro Model; individualized prevention; innovation; malignant stomach neoplasm; mortality; mortality disparity; novel; novel strategies; population based; precision oncology; premalignant; programs; psychosocial; racial difference; screening; social; survivorship; therapeutic target; translational impact

ABSTRACT – Overall Cancer health disparities span the continuum of cancer care, including prevention, screening, early detection, diagnosis, interception, treatment and survivorship, and are driven by a complex interplay between social, psycho-social, lifestyle, environmental, structural, and biological determinants of health. This Duke Cancer Health Disparities (DCHD) P20 SPORE application evolved from institutional efforts to address this complex, multi-level problem, and represents the work of a group of basic, translational, clinical and population scientists working collaboratively and synergistically to address disparities at particular points in the cancer disparity continuum, while recognizing the complexities of the larger problem of achieving cancer health equity. Our OVERALL GOAL is to develop or improve new or existing interventions and therapies through a better understanding of cancer disparities prevalent in the Duke Cancer Institute’s catchment area. We propose the following Aims: provide the infrastructure, oversight, and resources to conduct innovative translational research to reduce cancer disparities through two projects focused on under-studied disparities (Aim 1); ensure availability of expert support through Administrative and Shared Resource Cores (Aim 2); seed Developmental Research Program (DRP) projects and grow the cancer disparities research community (Aim 3); and complete planning and transition activities in preparation of a P50 SPORE application, including participating in and leading inter- SPORE activities (with other P20s and with P50 SPOREs) that enhance our collective impact (Aim 4). We propose two Projects. Project 1 is entitled “Race-related RNA splicing in non-small cell lung cancer: functional interrogation and therapeutic targeting”. Project 2 is entitled “Racial differences in host immune response and gastric carcinogenesis: translating underlying biology to promote gastric cancer interception”. Our two P20 Projects will be supported by an Administrative Core, a Biospecimen/Pathology Core (Core 1), and a Biostatistics and Bioinformatics Core (Core 2). DRP projects funded by the P20 may graduate into full projects for the future P50 SPORE. The expected outcomes of these aims are to conduct groundbreaking research in cancer health disparities, to develop novel approaches to mitigate these disparities, and to prepare and submit a full DCHD P50 SPORE application for the continuation and expansion of these efforts.

摘要 - 总体 癌症健康差异跨越了癌症护理的连续性，包括预防，筛查，早期检测， 诊断，拦截，治疗和生存制度，并由社会之间的复杂相互作用驱动 健康的心理社会，生活方式，环境，结构和生物学决定者。这个杜克癌 健康差异（DCHD）P20孢子应用程序从机构努力中发展为解决这一综合体， 多层问题，代表一组基本，翻译，临床和人口科学家的工作 在癌症差异的特定点进行协作和协同工作以解决差异 连续体，同时认识到实现癌症健康公平的更大问题的复杂性。我们的 总体目标是通过更好 了解杜克癌症研究所集水区普遍存在的癌症差异。我们建议 以下目的：提供基础架构，监督和资源来进行创新的转化研究 通过两个针对研究不足的分布的项目减少癌症分布（AIM 1）；确保可用性 通过行政和共享资源核心的专家支持（AIM 2）；种子发展研究 计划（DRP）项目并发展癌症分布研究社区（AIM 3）；和完整的计划 以及准备P50孢子应用程序的过渡活动，包括参与和领导 孢子活动（与其他P20和P50孢子）增强了我们的集体影响（AIM 4）。我们 提案两个项目。项目1的标题为“与种族相关的RNA剪接，在非小细胞肺癌中：功能性 审问和治疗性靶向”。项目2的标题为“宿主免疫反应中的种族差异和 胃癌发生：翻译潜在的生物学以促进胃癌截断。我们的两个P20 项目将由行政核心，生物循环/病理核心（核心1）和A支持 生物统计学和生物信息学核心（核心2）。 P20资助的DRP项目可能会毕业 未来P50孢子的项目。这些目标的预期结果是进行开创性 癌症健康分布的研究，开发新的方法来减轻这些分布并准备 并提交完整的DCHD P50孢子申请，以继续和扩展这些努力。