Precision Genome Engineering

精准基因组工程

• 批准号: 10608865
• 负责人: TERRY L. SHEPPARD
• 金额: $ 2.1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608865
• 关键词: Academia; Acceleration; Address; Agriculture; Animals; Authorization documentation; Biochemistry; Biology; Canada; Cell Therapy; Cellular biology; Clinic; Clinical Data; Collaborations; DNA; DNA Repair; Data; Development; Disease; Educational workshop; Environment; Enzymes; Ethicists; Ethics; Genes; Genetic Engineering; Genome; Genome engineering; Genomic DNA; Genomic Instability; Genomics; Health; Human; Industrialization; Investments; Joints; Knowledge; Learning; Livestock; Malignant Neoplasms; Medicine; Methodology; Nuclear Receptors; Outcome; Participant; Pathology; Plants; Research; Research Personnel; Risk; Safety; Science; Scientist; Specificity; System; Technology; Therapeutic; Translations; Work; authority; career development; clinical practice; design; drug candidate; epigenomics; genome editing; genotoxicity; improved; in vivo; interest; lectures; next generation; novel; posters; pre-clinical; programs; symposium; therapeutic development; tool; tool development; transcriptomics

ABSTRACT Support is requested for a Keystone Symposia conference entitled Precision Genome Engineering, organized by Drs. Laura Sepp-Lorenzino and Matthew Porteus. The conference will be held in Whistler, BC, Canada from March 19-23, 2023. Genome editing is a powerful and precise tool to change the sequence of cellular DNA for both better elucidating disease mechanisms and for developing new treatments to address underlying pathologies at the genomic, epigenomic and transcriptomic level. The basic understanding of how genome editing works, the development of new tools in genome editing, and the translation to clinic are evolving at a rapid pace. Likewise, gene editing is revolutionizing biology and therapeutics. An ever-expanding toolbox of editing enzymes and delivery solutions enable the precise manipulation of the genome, and it is fueling a diverse pipeline of applications in cell biology, plant and animal science and human therapeutics. Emerging clinical data from gene edited cell therapies along with preclinical data from in vivo delivered gene editing drug candidates are demonstrating the feasibility, versatility, and potential for efficacy and safety in humans. Furthermore, there is great interest and investment into gene editing for crops and livestock. Therefore, this Keystone Symposia conference will cover key aspects of the genome editing field, from fundamental biochemistry to tool development, to applications in biology, agriculture, and medicine. The conference will be of interest to scientists from both academia and biopharma, including regulators and ethicists. Moreover, this conference will also uniquely bring together scientists who have studied natural genome editing systems and natural DNA damage repair with scientists trying to develop novel genome editing systems through the juxtaposition of a conference focused on Genomic Instability and DNA Repair. These joint conferences will share two dual keynote lectures and two plenary sessions: Genome Instability and Cancer and Genome Editing and DNA Repair. Participants will also share mealtimes and poster sessions to enhance networking opportunities. In addition, this conference program includes a Career Development Workshop and features a panel discussion on Genome Editing Ethics. The program was also designed to provide ample opportunities for junior participates to be selected for workshop presentations as well as short talks during plenary sessions.

抽象的 请求支持题为“精密基因组工程”的 Keystone Symposia 会议，该会议已组织 由博士。劳拉·塞普-洛伦齐诺和马修·波特乌斯。会议将在加拿大不列颠哥伦比亚省惠斯勒举行 2023 年 3 月 19 日至 23 日。 基因组编辑是一种强大而精确的工具，可以改变细胞 DNA 序列，从而更好地 阐明疾病机制并开发新的治疗方法来解决潜在的病理学问题 基因组、表观基因组和转录组水平。对基因组编辑工作原理的基本了解 基因组编辑新工具的开发以及临床转化正在快速发展。 同样，基因编辑正在彻底改变生物学和治疗学。不断扩展的编辑工具箱 酶和递送解决方案使基因组的精确操作成为可能，并且它正在推动多样化的发展 细胞生物学、植物和动物科学以及人类治疗学中的应用管道。新兴临床 来自基因编辑细胞疗法的数据以及来自体内递送基因编辑药物的临床前数据 候选者正在证明其可行性、多功能性以及对人类功效和安全性的潜力。 此外，人们对农作物和牲畜的基因编辑产生了极大的兴趣和投资。因此，这 Keystone Symposia 会议将涵盖基因组编辑领域的关键方面，从基础到 生物化学到工具开发，再到生物学、农业和医学的应用。会议将于 学术界和生物制药界的科学家（包括监管机构和伦理学家）都对此感兴趣。而且，这 会议还将独特地将研究自然基因组编辑系统的科学家聚集在一起 自然 DNA 损伤修复，科学家们试图通过 同期举行的会议重点关注基因组不稳定性和 DNA 修复。这些联合会议将 分享两场双主题演讲和两场全体会议：基因组不稳定性和癌症与基因组 编辑和 DNA 修复。参与者还将分享用餐时间和海报会议，以加强交流 机会。此外，该会议计划还包括职业发展研讨会，并设有 关于基因组编辑伦理的小组讨论。该计划还旨在提供充足的机会 初级参与者被选为研讨会演讲以及全体会议期间的简短演讲。