Protecting the Health of Future Generations: Assessing and Preventing Exposures

保护子孙后代的健康：评估和预防暴露

• 批准号: 8993883
• 负责人: Charles Loren Buck
• 金额: $ 2.8万
• 依托单位: ALASKA COMMUNITY ACTION ON TOXICS (ACAT)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-08 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8993883
• 关键词: Affect; Alaska; Alaska Native; Animals; Arctic Regions; Arctic Research; Behavior; Biological Markers; Biological Monitoring; Chemicals; Child health care; Climate; Collaborations; Communities; Community Health Education; Data; Development; Diet; Disease; Distant; District of Columbia; Dust; Educational workshop; Elderly; Endocrine Disruptors; Endocrine disruption; Environmental Exposure; Environmental Health; Exposure to; Fishes; Flame Retardants; Food; Future; Future Generations; Gasterosteidae; Goals; Harvest; Health; Health Fairs; Health Personnel; Health Policy; Home environment; House Dust; Household; Human; Impairment; Indigenous; International; Intervention; Island; Leadership; Life; Link; Mammals; Marines; Measures; Mentors; Military Personnel; Modeling; Monitor; Outcome; Ownership; Plasma; Policies; Population; Prevalence; Process; Production; Public Health; Public Policy; Relative (related person); Reporting; Reproductive Health; Research; Research Institute; Research Project Grants; Risk; Route; Sampling; Scientist; Serum; Solid; Source; Special Event; Surface; Thyroid Gland; Training; Water; Work; Xenobiotics; Youth; base; college; community based participatory research; empowered; exposure pathway; food environment; meetings; member; phenyl ether; pollutant; pollutant transport; prevent; programs; public education; reproductive; tool; trend; wasting; young adult

DESCRIPTION (provided by applicant): This community-based participatory research project investigates exposures to two classes of emerging endocrine-disrupting chemicals (EDCs) with the Yupik people of St. Lawrence Island (SLI) in the Alaskan Arctic. The Arctic acts as a "cold trap" and is a hemispheric sink for persistent organic pollutants (POPs) that are transported through a well-documented process known as global distillation via prevailing atmospheric and oceanic currents from warmer regions. The Arctic is significant as an indicator region for long-range transport of legacy chemicals-a term applied to those POPs that have been banned or restricted-as well as emerging chemicals of concern. Arctic wildlife and people are also exposed to high levels of POPs from local sources, such as military toxics, solid waste dumps, and household dust. Exposure to POPs from both distant and local sources is a trend in the Arctic that is likely to increase due to increased global use and production of EDCs and climate warming. The purpose of this project is to initiate research partnerships that work in collaboration with the two Yupik villages of SLI to assess multiple exposure routes of two emerging EDCs-polybrominated diphenyl ethers (PBDEs) and perfluorinated compounds (PFCs). The project will assess exposures to PBDEs and PFCs in surface waters through analyses of contaminant levels and biomarkers for xenobiotic chemicals in the threespine stickleback fish. The research team will also analyze household dust for PBDEs and PFCs. Because the Yupik people of SLI depend on the harvest of wild foods to sustain them and their way of life, the research team will analyze levels of PBDEs and PFCs in traditional foods which are likely a major exposure pathway due to the biomagnification of POPs in marine mammals and fish that are critical components of the Yupik diet. This study will include a human biomonitoring component in order to assess levels of PBDEs and PFCs in human blood serum in relation to measures of thyroid health. The aim of this exposure assessment is to provide information, ownership of data, and training for the people of SLI so that they can plan and participate in public health actions to reduce environmental health risks. Finally, the research team collaborates with the leadership, elders, and youth of SLI to develop measures to prevent and mitigate environmental exposures through community educational programs and public policy actions, including community-based research institutes for college credit, health fairs for all community members, and workshops for health care providers.

描述（由申请人提供）：这个基于社区的参与性研究项目调查了与阿拉斯加北极地区圣劳伦斯岛（SLI）的两类新兴内分泌中断化学品（EDC）的接触。北极充当“冷陷阱”，是持续的有机污染物（POP）的半球水槽，这些水槽是通过备受证明的全球蒸馏的经过盛行的大气和海洋电流从温暖地区运输的，被称为全球蒸馏。北极是遗产化学物质长期运输的指标区域 - 适用于被禁止或受到限制的POP的术语以及新兴的关注化学品。北极野生动植物和人们也暴露于当地来源的高水平，例如军事毒物，固体废物垃圾场和家庭灰尘。从遥远和地方来源接触POP是北极的一种趋势，由于EDCS的全球使用和生产和气候变暖，可能会增加。该项目的目的是建立与SLI的两个Yupik村庄合作合作的研究合作伙伴，以评估两种新兴的EDCS-溶性溴化二苯基醚（PBDES）和完美化合物（PFCS）的多种曝光路线。该项目将通过分析三分之一粘土式鱼类中异种生物化学物质的污染物水平和生物标志物来评估地表水中PBDES和PFC的暴露。研究团队还将分析PBDE和PFCS的家庭灰尘。由于SLI的Yupik人民依赖于野生食品的收获以及维持其生活方式，因此研究团队将分析传统食品中PBDES和PFC的水平，这可能是海洋哺乳动物和鱼类中Pops在Yupik Diet的关键成分的Pops生物磁化的主要暴露途径。这项研究将包括人类的生物监测成分，以评估与甲状腺健康相关的人血清中PBDE和PFC的水平。这种暴露评估的目的是为SLI人民提供信息，数据所有权和培训，以便他们可以计划并参与公共卫生行动以减少环境健康风险。最后，研究小组与SLI的领导，长老和青年合作，通过社区教育计划和公共政策行动（包括基于社区的大学信贷研究所，所有社区成员的健康博览会，以及医疗保健提供者的研讨会）制定措施，以预防和减轻环境暴露。