Protecting the Health of Future Generations: Assessing and Preventing Exposures to Endocrine-Disrupting Flame Retardant Chemicals & PCBs in Two Alaska Native Arctic Communities on St. Lawrence Island

保护子孙后代的健康：评估和预防接触内分泌干扰性阻燃化学品

• 批准号: 10207627
• 负责人: Charles Loren Buck
• 金额: $ 54.43万
• 依托单位: ALASKA COMMUNITY ACTION ON TOXICS (ACAT)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-08 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207627
• 关键词: Address; Adult; Alaska; Alaska Native; Animal Model; Animals; Arctic Regions; Biological; Blood; Body Burden; Chemicals; Child; Child Development; Child Health; Collaborations; Communities; DNA Methylation; DNA Repair; DNA biosynthesis; Deposition; Development; Diet; Early Diagnosis; Early Intervention; Educational process of instructing; Educational workshop; Endocrine; Endocrine Disruptors; Endocrine disruption; Endocrinology; Environmental Health; Environmental Risk Factor; Esters; Exposure to; Female; Fishes; Flame Retardants; Food Contamination; Future; Future Generations; Gasterosteidae; Gene Expression; Gene Expression Profile; Health; Health Fairs; Histologic; Histology; Histopathology; House Dust; Household; Household Products; Human; Hypothyroidism; Incidence; Indigenous; Institutes; International; Intervention; Island; Knowledge; Lead; Level of Evidence; Link; Malignant Neoplasms; Measures; Methods; Military Personnel; Modeling; Monitor; Nail plate; Native-Born; Organ; Organophosphates; Outcome; Parents; Pathology; Physicians; Planet Earth; Poison; Policies; Polychlorinated Biphenyls; Population; Production; Public Health; Recommendation; Reporting; Research Institute; Research Project Grants; Risk; Scientist; Sentinel; Serum; Sexual Development; Site; Techniques; Thyroid Diseases; Time; Tissue-Specific Gene Expression; Tissues; Training; Work; Yup' ik; college; community based participatory research; community based research; estrogenic activity; experience; exposure pathway; exposure route; gene repression; geographic difference; hazard; health disparity; human data; improved; innovation; male; member; minimally invasive; outreach; persistent organic pollutants; pollutant transport; polybrominated diphenyl ether; prevent; public health intervention; reproductive; sex development disorder; stable isotope; symposium; teacher; tool; transcriptome; transcriptomics; webinar

Project Summary/Abstract The objectives of this community-based participatory research (CBPR) project are to investigate exposures, endocrine effects, and mechanisms of developmental disruption associated with legacy contaminants and emerging flame retardant chemicals in two Yupik communities on St. Lawrence Island (SLI) in arctic Alaska. The Arctic is subject to atmospheric deposition of globally-distilled persistent organic pollutants (POPs), acting as a hemispheric sink for POPs that are transported from lower latitudes. Thus, the Arctic is significant as an indicator region and contains some of the most highly contaminated animals and people in the world. This study addresses a primary public health concern of the people of SLI by focusing on the levels and effects of legacy and emerging contaminants on the development of children in an arctic indigenous population that is vulnerable, underserved, and experiences significant health disparities. Other studies have shown that young children are more highly exposed than adults. Using innovative and minimally invasive techniques, we will assess exposures of children to polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and emerging halogenated and non-halogenated organophosphate flame retardants. We will quantify PCBs and flame retardant chemicals in household dust, known to be an important exposure route. We will assess relationships among contaminant levels and evidence of health disruption via transcriptomics and endocrinology. We will use chemical concentrations in household dust and utilization of a subsistence diet as determined by stable isotope analysis to assess exposure pathways of these compounds. In order to understand the mechanistic basis of developmental disruption, and to have a reference for interpretation of human data, we will monitor patterns of gene expression, endocrinology, and histology of our resident fish model, the stickleback, from both contaminated and reference sites. Collectively, we will increase our understanding of routes of exposure, endocrine disruption, and effects on the transcriptome of Yupik children exposed to high levels of PCBs and flame retardant chemicals. This study provides an opportunity to investigate the levels of PBDEs and emerging flame retardants in nails and blood in relation to health outcomes of arctic indigenous children for the first time. Our CBPR project will also empower SLI communities with the knowledge and tools they need to address important health disparities in their communities. Our results will inform public health interventions and improve health outcomes of arctic children broadly. Furthermore, discovery of bioindicators relevant to early detection of developmental disruption will enable early intervention and improve health outcomes. Importantly, we will build capacity through our CBPR approach, public health interventions, and policy outreach, which will mitigate future exposure of SLI children to toxic chemicals.

项目摘要/摘要 这项基于社区的参与性研究（CBPR）项目的目标是调查暴露， 内分泌作用以及与遗产污染物相关的发育中断机制和 在阿拉斯加北极圣劳伦斯岛（SLI）的两个Yupik社区的新兴火焰化学品。 北极受到全球持续存在的有机污染物（POP）的大气沉积，作用 作为从较低纬度传输的流行音乐的半球水槽。因此，北极作为一个 指标区域并包含一些世界上最受污染的动物和人民。这 研究通过关注SLI人民的主要公共卫生关注 关于北极土著人口中儿童发展的遗产和新兴污染物 脆弱，服务不足和经历重大的健康差异。其他研究表明年轻 儿童比成年人更容易受到暴露。使用创新和微创技术，我们将 评估儿童对多氯联苯（PCB），多溴二苯基醚（PBDES）的暴露， 以及新兴的卤代和非卤代有机磷酸盐阻燃剂。我们将量化PCB 家用灰尘中的阻燃化学物质，已知是重要的曝光途径。我们将评估 污染物层次之间的关系以及通过转录组学和健康中断的证据 内分泌学。我们将在家庭灰尘中使用化学浓度，并利用生存饮食作为 通过稳定的同位素分析来评估这些化合物的暴露途径。为了 了解发育破坏的机械基础，并具有解释的参考 人类数据，我们将监视我们常驻鱼类的基因表达，内分泌学和组织学模式 模型，即污染和参考站点的粘性背。总体而言，我们将增加我们的 了解暴露途径，内分泌干扰以及对Yupik儿童转录组的影响 暴露于高水平的PCB和阻燃化学物质。这项研究提供了一个机会 研究指甲和血液中的PBDE和新兴火焰的水平与健康有关 北极土著儿童的结果是第一次。我们的CBPR项目还将授权SLI社区 有了知识和工具，他们需要解决社区中重要的健康差异。我们的 结果将为公共卫生干预措施提供信息，并广泛改善北极儿童的健康状况。 此外，发现与早期发现发育中断相关的生物指导者将提早 干预并改善健康状况。重要的是，我们将通过我们的CBPR方法来建立能力， 公共卫生干预措施和政策宣传，这将减轻SLI儿童的未来接触 化学物质。

项目成果

Persistent Organochlorine Pesticide Exposure Related to a Formerly Used Defense Site on St. Lawrence Island, Alaska: Data from Sentinel Fish and Human Sera.

• DOI: 10.1080/15287394.2015.1037412
• 发表时间: 2015
• 期刊: Journal of toxicology and environmental health. Part A
• 作者: Byrne S;Miller P;Waghiyi V;Buck CL;von Hippel FA;Carpenter DO
• 通讯作者: Carpenter DO

Patterns of Emergency Room Visits for Respiratory Diseases in New York State in Relation to Air Pollution, Poverty and Smoking.

• DOI: 10.3390/ijerph20043267
• 发表时间: 2023-02-13
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Madani, Najm Alsadat;Carpenter, David O
• 通讯作者: Carpenter, David O

Associations between serum polybrominated diphenyl ethers and thyroid hormones in a cross sectional study of a remote Alaska Native population.

• DOI: 10.1038/s41598-018-20443-9
• 发表时间: 2018-02-02
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Byrne SC;Miller P;Seguinot-Medina S;Waghiyi V;Buck CL;von Hippel FA;Carpenter DO
• 通讯作者: Carpenter DO

Exposure to perfluoroalkyl substances and associations with serum thyroid hormones in a remote population of Alaska Natives.

• DOI: 10.1016/j.envres.2018.06.014
• 发表时间: 2018-10
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Byrne SC;Miller P;Seguinot-Medina S;Waghiyi V;Buck CL;von Hippel FA;Carpenter DO
• 通讯作者: Carpenter DO

Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Concerning Trends for Current-Use PFAS.

• DOI: 10.1021/acs.est.0c06978
• 发表时间: 2021-05
• 期刊: Environmental science & technology
• 影响因子: 11.4
• 作者: Guomao Zheng;Erika Schreder;J. Dempsey;Nancy Uding;Valerie Chu;G. Andres;S. Sathyanarayana;Amina Salamova