Threat-Related Negative Valence Systems, Child Victimization, and Anxiety_Supplement

与威胁相关的负价系统、儿童受害和焦虑_补充

基本信息

批准号：
10597417
负责人：
CARLA KMETT DANIELSON
金额：
$ 22.11万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10597417
关键词：
Accounting Acute Address Administrative Supplement Adolescence Affect Age Amygdaloid structure Anterior Anxiety Behavioral Biological COVID-19 pandemic Childhood Classification Clinical assessments Collection Communities Data Collection Development Diagnosis Ensure Event-Related Potentials Exposure to Funding Goals Guidelines Hydrocortisone Insula of Reil Interpersonal Violence Intervention Lead Link Longevity Longitudinal Studies Longitudinal cohort Measures Mediating Mental Health Mental disorders Negative Valence Outcome Panic Participant Pattern Persons Phenotype Physiological Physiology Plant Roots Prevention Psychopathology Research Research Domain Criteria Risk Risk Factors Sampling Societies Startle Reaction Symptoms System Telephone Testing Time TimeLine Translating Visit Writing Youth anxiety states anxiety symptoms anxious associated symptom base boys child and adolescent victimization cingulate cortex cohort cost data cleaning design emotional distress experience follow-up functional MRI scan girls improved magnetic resonance imaging/electroencephalography neuroimaging pandemic disease parent project participant retention personalized medicine physical conditioning predicting response psychologic recruit relating to nervous system resilience response self-reported anxiety sex violence exposure

项目摘要

Interpersonal violence (IPV) exposure affects 1 in 2 youth and levies tremendous physical and mental health burdens on victims and society. Childhood IPV exposure is a well-established risk factor for anxiety and other mental health problems across the lifespan. A paucity of longitudinal studies assessing multiple threat-related mechanisms, across multiple units of analysis, and at key times in development has been a critical barrier to informing the design of personalized treatments to target root causes of post-IPV psychopathology. The overarching goal of this project (the “CHARM study”) is to examine developmental trajectories of threat-related NVS measures into adolescence, as a function of exposure to IPV, in an effort to better link IPV and anxiety through changes in these measures. The specific aims of this project are: 1) to identify threat-related NVS constructs that connect lifetime IPV to anxious symptoms in youth cross-sectionally; 2) to investigate longitudinally the degree to which IPV sensitizes trajectories of NVS measures across three age cohorts (grades 3, 6, 9 at baseline); and 3) to investigate the degree to which trajectories of NVS measures predict anxiety symptoms over time after accounting for initial anxiety symptoms and IPV status. The study had successfully recruited its full sample (N=364) and longitudinal retention was progressing as planned until March, 2020, when the COVID-19 pandemic (and subsequent mandatory guidelines impacting in-person data collection) reduced retention across the representative sample. Pandemic disruptions have required increased intensive efforts in participant retention, particularly for the final assessment (Lab Visit 3) that includes the follow-up fMRI scan, which has translated into a delayed timeline and increased costs. The proposed Administrative Supplement is essential to help cover these unexpected costs to complete the outstanding in-person data collection, as well as final data cleaning, analysis, and write up of results, ensuring that the longitudinal aims are successfully met and that maximum impact is yielded from the study.

人际暴力 (IPV) 暴露影响了二分之一的青少年，并对身心健康造成巨大影响儿童期 IPV 暴露是导致焦虑和其他疾病的一个公认的风险因素。缺乏评估多种威胁相关的纵向研究。跨多个分析单位以及在发展的关键时刻的机制一直是一个关键障碍为个性化治疗的设计提供信息，以针对 IPV 后精神病理学的根本原因。该项目（“CHARM 研究”）的总体目标是检查与威胁相关的发展轨迹 NVS 根据 IPV 暴露情况对青春期进行测量，以更好地将 IPV 与焦虑联系起来通过改变这些措施，该项目的具体目标是： 1) 识别与威胁相关的 NVS。将终生 IPV 与青少年焦虑症状联系起来的构建 2) 进行调查；纵向地，IPV 对三个年龄组的 NVS 测量轨迹的敏感性程度（年级 3、6、9 基线）；以及 3）调查 NVS 测量轨迹预测焦虑的程度在考虑了最初的焦虑症状和 IPV 状态后，随着时间的推移，该研究成功了。招募了完整样本 (N=364)，并且纵向保留正在按计划进行，直到 2020 年 3 月 COVID-19 大流行（以及随后影响面对面数据收集的强制性指南）减少保留整个代表性样本需要加大力度。参与者保留，特别是最终评估（实验室访问 3），包括后续功能磁共振成像扫描，这导致了时间表的延迟和成本的增加。对于帮助支付这些意外成本以完成出色的现场数据收集至关重要，以及最终数据清理、分析和结果编写，确保成功实现纵向目标该研究产生了最大的影响。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

儿童和青少年的嗅觉功能与焦虑相关的变化。

DOI：
发表时间：
2021-01-01
期刊：
影响因子：
3.5
作者：
Cortese, Bernadette M;Uhde, Thomas W;Schumann, Aicko Y;McTeague, Lisa M;Sege, Christopher T;Calhoun, Casey D;Danielson, Carla Kmett
通讯作者：
Danielson, Carla Kmett

Safety and Efficacy of Exposure-Based Risk Reduction Through Family Therapy for Co-occurring Substance Use Problems and Posttraumatic Stress Disorder Symptoms Among Adolescents: A Randomized Clinical Trial.

通过家庭治疗减少青少年同时发生的药物使用问题和创伤后应激障碍症状的暴露风险的安全性和有效性：一项随机临床试验。

DOI：
发表时间：
2020
期刊：
影响因子：
25.8
作者：
Danielson, Carla Kmett;Adams, Zachary;McCart, Michael R;Chapman, Jason E;Sheidow, Ashli J;Walker, Jesse;Smalling, Anna;de Arellano, Michael A
通讯作者：
de Arellano, Michael A

A qualitative analysis of black mother preparation for bias messages following incidents of racism-related violence.

对黑人母亲在种族主义相关暴力事件后对偏见信息的准备情况进行定性分析。

DOI：
发表时间：
2024-02
期刊：
影响因子：
0
作者：
Bernard, Donte L;Saleem, Farzana T;Moreland, Angela D;Shacklewood, Curtisha;Danielson, Carla Kmett
通讯作者：
Danielson, Carla Kmett

What's the harm? Alcohol and marijuana use and perceived risks of unprotected sex among adolescents and young adults.

有什么坏处呢？

DOI：
发表时间：
2018-01
期刊：
影响因子：
4.4
作者：
Dir, Allyson L;Gilmore, Amanda K;Moreland, Angela D;Davidson, Tatiana M;Borkman, April L;Rheingold, Alyssa A;Danielson, Carla Kmett
通讯作者：
Danielson, Carla Kmett

Risk reduction through family therapy (RRFT): Protocol of a randomized controlled efficacy trial of an integrative treatment for co-occurring substance use problems and posttraumatic stress disorder symptoms in adolescents who have experienced interperson

通过家庭治疗（RRFT）降低风险：针对经历过人际交往的青少年同时发生的物质使用问题和创伤后应激障碍症状进行综合治疗的随机对照疗效试验方案

DOI：
发表时间：
2020-06
期刊：
影响因子：
2.2
作者：
Hahn, Austin M;Adams, Zachary W;Chapman, Jason;McCart, Michael R;Sheidow, Ashli J;de Arellano, Michael A;Danielson, Carla Kmett
通讯作者：
Danielson, Carla Kmett