Postdoctoral Training in Biomedical MRI and MRS

生物医学 MRI 和 MRS 博士后培训

• 批准号: 7056668
• 负责人: John C Gore
• 金额: $ 25.07万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056668
• 关键词: Postdoctoral; Training; Biomedical; MRI; MRS; Postdoctoral; Training; Biomedical; MRI; MRS

DESCRIPTION (provided by applicant): This application seeks support for a comprehensive postdoctoral training program in magnetic resonance imaging (MRI) and spectroscopy (MRS) at Vanderbilt University which will be provided by an experienced and expert group of faculty and research staff. MR methods are well established as amongst the most powerful and widespread of biomedical imaging techniques yet major advancements in technology and increases in their impact continue to occur. MR methods serve not only as the single most important modality in diagnostic imaging but also provide crucial insights into biological processes and structure to address fundamental questions in biomedical research. Advanced MR systems for research are available at a large number of medical centers, and further advances in their uses will occur inevitably as systems with stronger field magnets become more widespread. There is, however, a shortage and a critical need for appropriately trained scientists capable of exploiting the potential of MR techniques, who are aware of the uses and limitations of MR methods, and of how MRI/MRS may be implemented, advanced, and integrated with information available from other modalities. We propose a comprehensive training program designed for 8 outstanding postdoctoral scientists (4 in each of a two-year program) who will usually have had little previous significant experience in biomedical MRI and MRS. Postdoctoral trainees from physics, chemistry, biology, engineering or medicine will receive thorough and exemplary instruction in all of the cognate areas relevant to biomedical NMR in a coherent program that includes 18 Ph.D faculty experienced in biomedical MRI/S and their applications. This will be accomplished through an educational program, consisting of courses, seminars, and journal clubs; a practical program, consisting of faculty-led tutorials and practical training; and a research program, in which trainees will be integrated into an active research program. These programs illustrate most major aspects of the applications of MR methods in humans and animals and include functional and structural brain imaging, cancer biology, studies of basic relaxation phenomena and diffusion, blood flow and perfusion, metabolic imaging, image processing and analysis, and clinical MRS and MRI. Trainees will have access to outstanding facilities including human MR systems with field strengths of 1.5, 3, and 7T; animal MR systems of 4.7, 7, and 9.4T; and other imaging modalities (including optical imaging, microCT, and microPET). Trainees will be mentored in the ethics and methods of biomedical research, as well as in grant writing and other important career skills. The programs, personnel, and facilities at Vanderbilt provide unique opportunities for scientists to receive advanced training in biomedical NMR of the highest caliber, and will help to ensure that the remarkable insights into biology and disease that are possible with MRI and MRS will be realized.

描述（由申请人提供）：本申请寻求支持范德比尔特大学的磁共振成像（MRI）和光谱学（MRS）的全面的博士后培训计划，该计划将由经验丰富的教职员工和研究人员提供。 MR方法已成为最强大，最广泛的生物医学成像技术，但在技术方面的重大进步和影响力的增长仍在继续。 MR方法不仅是诊断成像中最重要的一种方式，而且还提供了对生物学过程和结构的重要见解，以解决生物医学研究中的基本问题。 高级MR系统可用于大量医疗中心，随着磁场较强的系统变得更加普遍，其用途的进一步进展将不可避免地发生。 但是，对于能够利用MR技术潜力的经过适当培训的科学家的短缺和迫切需求，他们意识到MR方法的用途和局限性以及如何实施，高级和与其他模式可用信息集成的MRI/MRS。 我们提出了一项全面的培训计划，专为8位杰出的博士后科学家（两年计划中的4个）设计，他们通常在生物医学MRI和MRS方面几乎没有重要的经验。 物理，化学，生物学，工程或医学的博士后学员将在与生物医学NMR相关的所有同源区域中获得彻底和典范的指导，其中包括18个在生物医学MRI/S及其应用中经验丰富的博士学位。 这将通过一个教育计划来完成，包括课程，研讨会和期刊俱乐部；一个实用计划，由教师领导的教程和实践培训组成；以及一项研究计划，该计划将在该计划中将学员纳入活跃的研究计划。 这些程序说明了MR方法在人类和动物中应用的大多数主要方面，包括功能性和结构性脑成像，癌症生物学，基本弛豫现象的研究和扩散，血流和灌注，代谢成像，图像处理和分析以及临床MRS和MRI。 受训人员将可以使用出色的设施，包括人类MR系统，其现场优势为1.5、3和7T；动物MR系统为4.7、7和9.4T；以及其他成像模式（包括光学成像，微观和微型）。 学员将受到生物医学研究的道德和方法的指导，以及赠款写作和其他重要的职业技能。 范德比尔特（Vanderbilt）的计划，人员和设施为科学家提供了独特的机会，可以接受最高口径的生物医学NMR的高级培训，并将有助于确保对MRI和MRS可能对生物学和疾病的显着见解。