Threat-Related Negative Valence Systems, Child Victimization, and Anxiety

与威胁相关的负价系统、儿童受害和焦虑

基本信息

批准号：
9331981
负责人：
CARLA KMETT DANIELSON
金额：
$ 75.25万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-03 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9331981
关键词：
Accounting Acute Address Adolescence Affect Age Amygdaloid structure Anterior Anxiety Assessment tool Behavioral Biological Caregivers Child Childhood Classification Clinical Research Clinical assessments Communities Development Developmental Course Diagnosis Electroencephalography Enrollment Environment Event-Related Potentials Exposure to Family Future Gender Goals Heterogeneity Hydrocortisone Insula of Reil Interpersonal Violence Intervention Investigation Laboratories Lead Link Longevity Longitudinal Studies Longitudinal cohort Magnetic Resonance Imaging Measures Mediating Mental Depression Mental Health Mental disorders Nature Negative Valence Outcome Participant Patient Self-Report Pattern Persons Phonation Physiological Physiology Plant Roots Prevention Psychopathology Recruitment Activity Research Research Domain Criteria Risk Risk Factors Sampling Societies Stress Symptoms System Telephone Testing Time Traumatology Violence Visit Youth anxiety states anxiety symptoms base boys child and adolescent victimization cingulate cortex clinical care cohort common symptom design emotional distress experience girls improved neural circuit neurodevelopment neuroimaging personalized medicine physical conditioning predicting response prospective psychobiologic psychologic relating to nervous system resilience response self reported behavior time use translational neuroscience

项目摘要

Interpersonal violence (IPV) exposure affects 1 in 2 youth and levies tremendous physical and mental health burdens on victims and society. Childhood IPV exposure is a well-established risk factor for anxiety and other mental health problems across the lifespan. There is great variability among youth in the nature and timing of IPV exposure and considerable heterogeneity in mental health outcomes. Such heterogeneity in outcomes may be explained by various Research Domain Criteria (RDoC) constructs, including Negative Valence Systems (NVS) involving responses to threat. That is, disruptions in the functioning and development of neural and physiological systems associated with threat processing may account for heightened anxiety symptoms commonly observed following IPV. A paucity of longitudinal studies assessing multiple threat-related mechanisms, across multiple units of analysis, and at key times in development has been a critical barrier to informing the design of personalized treatments to target root causes of post-IPV psychopathology. The overarching goal of this project is to examine developmental trajectories of threat-related NVS measures into adolescence, as a function of exposure to IPV, in an effort to better link IPV and anxiety through changes in these measures. The specific aims of this project are: 1) to identify threat-related NVS constructs that connect lifetime IPV to anxious symptoms in youth cross-sectionally; 2) to investigate longitudinally the degree to which IPV sensitizes trajectories of NVS measures over a two-year period across three age cohorts (grades 3, 6, 9 at baseline); and 3) to investigate the degree to which trajectories of NVS measures predict anxiety symptoms over a 2-year period after accounting for initial anxiety symptoms and IPV status. An exploratory aim is to examine how amygdala activity and ACC functioning at baseline and overtime predict changes in other threat- related NVS measures (ERP, startle, ERN, cortisol reactivity) over time. To accomplish the aims, the approach involves studying the contributions of three threat-related NVS constructs, including responses to acute threat, potential threat, and sustained threat. These constructs will be measured across multiple units of analysis (neural circuitry, physiology, behavior/self-report) and over time using a battery of well-validated translational neuroscience laboratory paradigms and assessment tools. An accelerated longitudinal cohort design will be used to test key developmental questions (e.g., whether pubertal status moderates the effect of IPV on potential threat or sustained threat). Three cohorts of children (total n=360) and their caregivers will be enrolled and prospectively across 3 annual in-person lab assessments, with phone-based assessments in between. A community sample representing a broad continuum of IPV experiences and a wide range of anxiety symptoms will be recruited. By studying multiple NVS constructs over time across multiple units of analysis, findings will clarify the timing and developmental course of psychobiological vulnerabilities to anxiety problems in IPV- exposed youth, and will impact clinical care and future clinical research classification.

人际暴力 (IPV) 暴露影响了二分之一的青少年，并对身心健康造成巨大影响给受害者和社会带来负担。儿童时期 IPV 暴露是导致焦虑和其他疾病的一个公认的危险因素。整个生命周期的心理健康问题。青少年之间在性质和时间上存在很大差异 IPV 暴露和心理健康结果的显着异质性。结果的这种异质性可以通过各种研究领域标准 (RDoC) 结构来解释，包括负价涉及威胁响应的系统 (NVS)。也就是说，神经功能和发育的破坏与威胁处理相关的生理系统可能会导致焦虑症状加剧通常在 IPV 后观察到。缺乏评估多种威胁相关的纵向研究跨多个分析单位以及在发展的关键时刻的机制一直是一个关键障碍为个性化治疗的设计提供信息，以针对 IPV 后精神病理学的根本原因。这该项目的总体目标是研究与威胁相关的 NVS 措施的发展轨迹青春期，作为接触 IPV 的函数，试图通过改变 IPV 和焦虑更好地联系起来这些措施。该项目的具体目标是：1) 识别与威胁相关的 NVS 结构，这些结构连接青少年横断面的终生 IPV 与焦虑症状的关系； 2）纵向调查的程度 IPV 使三个年龄组（3、6、9 年级）两年内 NVS 测量的轨迹变得敏感基线）； 3) 调查 NVS 测量轨迹预测焦虑症状的程度考虑到最初的焦虑症状和 IPV 状态后的 2 年多时间。一个探索性的目标是检查杏仁核活动和 ACC 在基线和超时时的功能如何预测其他威胁的变化 - 随着时间的推移，相关的 NVS 测量（ERP、惊吓、ERN、皮质醇反应性）。为实现目标，采取的方法涉及研究三种与威胁相关的 NVS 结构的贡献，包括对严重威胁的响应，潜在威胁和持续威胁。这些结构将通过多个分析单元进行测量（神经回路、生理学、行为/自我报告）并随着时间的推移使用一系列经过充分验证的转化神经科学实验室范例和评估工具。加速纵向队列设计将是用于测试关键的发育问题（例如，青春期状态是否会调节 IPV 对潜在威胁或持续威胁）。将招募三组儿童（总共 n=360）及其照顾者并前瞻性地进行 3 次年度现场实验室评估，其间进行基于电话的评估。一个代表广泛的 IPV 经历和广泛的焦虑症状的社区样本将被招募。通过跨多个分析单元研究多个 NVS 结构，研究结果将阐明IPV-中焦虑问题的心理生物学脆弱性的时间和发展过程暴露于青少年，并将影响临床护理和未来的临床研究分类。