Replacement and Upgrade of a 3T MR Scanner for Research

用于研究的 3T MR 扫描仪的更换和升级

• 批准号: 9075982
• 负责人: John C Gore
• 金额: $ 199.78万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2019-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9075982
• 关键词: Abdomen; Aging; Architecture; Biochemistry; Biological Process; Brain; Breast; Categories; Clinical Management; Data; Development; Diagnosis; Functional Magnetic Resonance Imaging; Funding; Healthcare; Housing; Image; Institutes; Magnetic Resonance Imaging; Malignant Neoplasms; Manufacturer Name; Metabolic Diseases; Methods; Morphology; Neurosciences; Noise; Patients; Physics; Physiology; Population; RF coil; Research; Research Personnel; Research Project Grants; Resources; Science; Scientist; Signal Transduction; Spectrum Analysis; Support System; System; Time; Tissues; United States National Institutes of Health; Universities; Vertebral column; digital; experience; falls; human subject; imaging biomarker; imaging modality; improved; in vivo; instrument; meetings; neuropsychiatry; non-invasive imaging; soft tissue; spectroscopic imaging

 DESCRIPTION (provided by applicant): This is an application for funding to replace and upgrade a 3 Tesla magnetic resonance imaging (MRI) and spectroscopy (MRS) system for human subjects that has been in use for research full-time for over a decade at Vanderbilt University. The current scanner is heavily used by over 60 active investigators with NIH funding who rely on high quality MRI and MRS data for diverse research applications. We aim to install a 3Tesla 70-cm bore Ingenia scanner manufactured by Philips Healthcare to replace the existing scanner, which is an aging system no longer fully supported by the manufacturer. MRI is well established as the single most powerful non-invasive imaging modality for studies of soft-tissues. MRI and MRS can be used to provide uniquely valuable information about tissue composition, morphology and function, as well as quantitative descriptions of many underlying biological processes. Our current system unfortunately precludes the exploration of several new avenues of MR research and some new applications are beyond the capabilities of our current machine. The new system will provide three major specific advantages. [1] it will be able to implement new methods such as multi-band acquisitions that cannot be implemented on the current platform, and investigators can be assured of continuing support for several years; [2] it has a larger bore, so we can image larger patients that currently are excluded from studies, and achieve higher RF and main field uniformity. The larger bore is essential to meet the challenges of our local population and to permit more and better studies of the abdomen, spine and breast; [3] the new all-digital architecture with direct conversion of MR signals within the RF coils produces images with higher (40%) signal to noise ratio. In this application we feature 29 selected investigators all of whom are experienced users of the current 3T scanner, in a variety of research applications. Their research projects fall into 4 main categories: (1) Imaging physics, the development of new and improved MR imaging methods: (2) Cancer, and applications of MRI and MRS for diagnosis and clinical management, including the development of imaging biomarkers to assess treatments: (3) Neuroscience, and the application of structural and functional MRI to studies of the architecture and functional organization of the brain, in normal as well as neuropsychiatric conditions: (4) Metabolic Disorders, and the development and applications of advanced MR methods to studies of physiology and biochemistry in vivo. The projects of the Users described herein would require approximately 80% of the useable time available on the scanner, and the remainder would be used for exploratory research and new directions. The scanner will be housed and managed within the Vanderbilt University Institute of Imaging Science, and will remain a primary research resource for a large group of imaging scientists. The instrument will be supported by an established group of MR imaging experts and support staff. A comprehensive plan has been developed for the financial and technical support of the system as well as for its management, and the system is assured of strong institutional support and oversight.

 描述（由应用程序提供）：这是用于替换和升级3特斯拉磁共振成像（MRI）和光谱（MRS）系统的资金应用程序，用于在范德比尔特大学全日制研究已有十多年的人类受试者。当前的扫描仪已被60多名活跃研究人员大量使用，他们拥有NIH资金，他们依靠高质量的MRI和MRS数据用于潜水员研究应用。我们的目标是安装由飞利浦Healthcare生产的3tesla 70厘米孔Ingenia扫描仪，以取代现有的扫描仪，这是一种不再得到制造商的老化系统。 MRI已被确立为软组织研究的最强大的非侵入性成像方式。 MRI和MRS可用于提供有关组织组成，形态和功能的独特有价值的信息，以及许多基本生物学过程的定量描述。不幸的是，我们当前的系统排除了对MR研究的几种新途径的探索，并且一些新应用超出了我们当前机器的功能。新系统将提供三个主要的特定优势。 [1]它将能够实施新的方法，例如在当前平台上无法实施的多波段采集，并且可以假定研究人员在几年中继续支持； [2]它具有较大的孔，因此我们可以对目前排除在研究之外的大型患者进行成像，并获得更高的RF和主场均匀性。较大的孔对于应对当地人口的挑战至关重要，并允许对腹部，脊柱和乳房进行更多更好的研究； [3]带有RF线圈内MR信号直接转换的新的全数字体系结构可产生具有较高（40％）信号噪声比的图像。在此应用程序中，我们为29名选定的研究人员提供了所有这些研究应用程序中当前3T扫描仪的经验丰富的用户。他们的研究项目分为4个主要类别：（1）成像物理学， 新的和改进的MR成像方法的开发：（2）MRI和MRS在诊断和临床管理中的应用，包括开发成像生物标志物来评估治疗方法：（3）神经科学以及在正常和神经精神的构建中的结构和功能组织中的结构和功能性MRI的应用，以及MIR的构建和功能组织，以及MIR，MIR，MIR（4）相互调查（4）群众（4）（4）相互群体（4）群众（4）（4）群众（4）（4）群众（4）群体（4）群众（4）群体（4）群体（4）群体（4）群众（4）群体（4）群体（4）（4）群体（4）群体（4）群体（4）群体（4）群体（4）群体（4）群体（4）群体（4）群体（4）群体（4）群体（4）体内生理学和生物化学研究的方法。本文所述的用户的项目将需要扫描仪上可用的约80％的可用时间，其余的将用于探索性研究和新方向。扫描仪将在范德比尔特大学成像科学研究所内进行安置和管理，并将成为大量成像科学家的主要研究资源。该工具将得到制定的综合计划，以支持系统的财务和技术支持，并为其管理层提供了支持，并且该系统被认为具有强大的机构支持和监督。

项目成果

A registration strategy to characterize DTI-observed changes in skeletal muscle architecture due to passive shortening.

一种配准策略，用于表征由于被动缩短而导致的 DTI 观察到的骨骼肌结构变化。

• DOI: 10.1101/2024.04.11.589123
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Hooijmans,MelissaT;Lockard,CarlyA;Zhou,Xingyu;Coolbaugh,Crystal;PinedaGuzman,Roberto;Kersh,MarianaE;Damon,BruceM
• 通讯作者: Damon,BruceM

Reproducibility of liver iron concentration estimates in MRI through R2* measurement determined by least-squares curve fitting.

• DOI: 10.1002/acm2.13096
• 发表时间: 2020-12
• 期刊: Journal of applied clinical medical physics
• 影响因子: 2.1
• 作者: Headley AM;Grice JV;Pickens DR
• 通讯作者: Pickens DR

Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array.

使用 1 MHz 超声相控阵在猕猴中打开小体积血脑屏障。

• DOI: 10.1016/j.jconrel.2023.10.015
• 发表时间: 2023
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Manuel,ThomasJ;Sigona,MichelleK;Phipps,MAnthony;Kusunose,Jiro;Luo,Huiwen;Yang,Pai-Feng;Newton,AllenT;Gore,JohnC;Grissom,William;Chen,LiMin;Caskey,CharlesF
• 通讯作者: Caskey,CharlesF

Minimal artifact actively shimmed metallic needles in MRI.

• DOI: 10.1002/mrm.28977
• 发表时间: 2022-01
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Sengupta S;Yan X;Hoyt TL;Drake G;Gunderman A;Chen Y
• 通讯作者: Chen Y