A PET-CT Scanner for Translational Research

用于转化研究的 PET-CT 扫描仪

• 批准号: 9307369
• 负责人: John C Gore
• 金额: $ 196.34万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-30 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9307369
• 关键词: PET; CT; Scanner; Translational; Research

DESCRIPTION (provided by applicant): This application requests funds to purchase an integrated Positron Emission and X-ray Computed Tomography (PET-CT) Imaging system for use in numerous funded research studies involving human subjects or large animals at Vanderbilt University. PET imaging is the primary molecular imaging method available for non-invasive, translational human studies. Because of its high sensitivity and the availability of a wide range of biologically relevant radiotracers, PET can be used (amongst others) to detect and diagnose cancer, to assess specific cellular and molecular characteristics of tumors, to quantify brain neurochemistry and metabolism, to study the distributions and effects of novel pharmaceuticals, and to report on multiple cellular and molecular imaging biomarkers in a variety of important clinical applications. In the brain PET is uniquely capable of assessing neurotransmitter levels, occupancies and transport in neuropsychiatric applications, and is a crucial tool in the evaluation of novel drugs and interventions. In cancer, PET is a primary modality for use as a biomarker of tumor phenotype, treatment response and for characterizing the effects of novel targeted treatments at a molecular level. The uses and applications of PET rely on the availability of suitable radionuclides that are labeled with positron-emitting atoms such as 19F and 11C. Vanderbilt has a well- established PET Center and cyclotron, along with extensive radiochemistry laboratories and personnel, but the only PET scanner reliably available for research studies is a microPET that cannot accommodate people or large animals. The requested instrument would meet the extensive demand for research PET studies of humans and large animals in a leading medical center. Moreover, as all modern PET scanners also incorporate CT for co-registration, the proposed instrument would also provide access for research CT studies as well. Although we possess dedicated CT scanners for small animals, we have no research CT capability for human subjects and imaging of large animals is not allowed by law on our clinical systems. The PET-CT scanner would provide new types of information that will complement and enhance the ongoing research of numerous NIH-funded projects, SPORES and Centers, and would be a unique resource for multiple investigators. The Radiochemistry Center at Vanderbilt is experienced in producing an array of compounds that will be used to study tumor metabolism, hypoxia and proliferation, the expression levels of specific cell receptors and proteins, and various neuroreceptors, transporters and modulators. Several of the CT applications are focused on the development of image-guided interventions. The system will be housed and managed in a dedicated Institute of Imaging Science that is experienced in providing and operating major core shared research resources for investigators, and will be supported by an expert staff and user group. A comprehensive plan for Administration and Financial Management of the resource has been developed.

描述（由申请人提供）：本申请要求资金购买综合的正电子发射和X射线计算机断层扫描（PET-CT）成像系统，用于在范德比尔特大学的许多资助研究中使用，涉及人类受试者或大型动物。 PET成像是用于非侵入性，翻译人类研究的主要分子成像方法。由于其较高的敏感性和广泛的生物学相关放射性示踪剂的可用性，可以使用PET（除其他外）来检测和诊断癌症，以评估肿瘤的特定细胞和分子特征，以量化脑神经化学和代谢，以研究新型药物的分布和效果，以研究对多个细胞和多种细胞的分布和影响。在大脑中，宠物具有独特的能力，能够评估神经精神应用中的神经递质水平，占用和运输，并且是评估新药物和干预措施的关键工具。在癌症中，PET是用作肿瘤表型生物标志物，治疗反应以及表征分子水平上新型靶向治疗的影响的主要方式。 PET的用途和应用取决于与正电子发射原子（如19F和11C）标记的合适放射性核素的可用性。范德比尔特（Vanderbilt）拥有一个良好的宠物中心和回旋子，以及广泛的放射化学实验室和人员，但是唯一可靠地用于研究研究的宠物扫描仪是无法容纳人或大型动物的微型网络。所请求的工具将满足对人类和大型动物的研究宠物研究的广泛需求。此外，由于所有现代PET扫描仪还合并了用于共同注册的CT，因此拟议的工具还将为研究CT研究提供访问权限。尽管我们为小动物拥有专用的CT扫描仪，但我们没有针对人类受试者的研究能力，并且在我们的临床系统上，不允许对大型动物进行成像。 PET-CT扫描仪将提供新类型的信息，以补充和增强对众多NIH资助的项目，孢子和中心的持续研究，并将成为多个研究人员的独特资源。范德比尔特（Vanderbilt）的放射化学中心在生产一系列化合物中经验丰富，这些化合物将用于研究肿瘤代谢，缺氧和增殖，特定细胞受体和蛋白质的表达水平以及各种神经感受器，转运蛋白和调节剂。一些CT应用程序集中在图像引导的干预措施的发展上。该系统将在专门的成像科学研究所内置和管理，该研究所在为研究人员提供和操作主要的核心共享研究资源方面经验丰富，并将得到专家员工和用户组的支持。已经制定了对资源管理和财务管理的全面计划。

项目成果

Increased microglia activation in late non-central nervous system cancer survivors links to chronic systemic symptomatology.

• DOI: 10.1002/hbm.26491
• 发表时间: 2023-12-01
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Schoenberg, Poppy L. A.;Song, Alexander K.;Mohr, Emily M.;Rogers, Baxter P.;Peterson, Todd E.;Murphy, Barbara A.
• 通讯作者: Murphy, Barbara A.