Administrative Core

行政核心

• 批准号: 10596708
• 负责人: PEI ZHONG
• 金额: $ 4.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596708
• 关键词: Ablation; Address; Benign; Clinical; Clinical Research; Clinical Treatment; Collaborations; Communities; Consultations; Data Scientist; Development; Development Plans; Disease; Dust; Educational workshop; Ensure; Fiber; Frequencies; Future; Goals; Health Expenditures; Holmium; In Situ; Injury to Kidney; Knowledge; Laser Lithotripsy; Lasers; Lead; Liquid substance; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Methods; Nanotechnology; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Outcome; Patients; Play; Positioning Attribute; Prevalence; Procedures; Program Development; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Role; SECTM1 gene; Sampling; Science; Structure; Talents; Technology; Thulium; Time; Tissues; Toxic effect; Training; Treatment outcome; Universities; Ureteroscopy; Urinary Calculi; Urology; Work; absorption; career; career development; cost; data sharing; experience; improved; innovation; member; multidisciplinary; nanomaterials; nanoparticle; novel strategies; operation; programs; theories; tissue injury; tool; treatment choice; urologic

ADMINISTRATIVE CORE (AC) PROJECT SUMMARY/ABSTRACT Urinary stone disease (USD) is the second most costly urologic condition in the US, with an annual healthcare expenditure of more than $2 billion. Ureteroscopy (URS) via laser lithotripsy (LL) is the treatment of choice for USD. Recently, the introduction of high power/high frequency Holmium (Ho): YAG lasers and Thulium Fiber Laser (TFL) has fundamentally altered the clinical mode of operation in LL. Contemporary LL is often performed using dusting and pop-dusting modes that pulverize stone to dust in situ without the need for fragment extraction. However, there is an unmet need to develop approaches that can address some of the challenges of dusting and pop-dusting in order to significantly improve the clinical treatment outcome regardless of stone composition, shorten the procedure time, and lessen the risk of tissue injury. The proposed Duke FORWARD P20 Urology Center (Duke FORWARD Center) will tackle some of the most pressing problems in treating USD with LL. The Center's Research Project (RP) will focus on modifying the fluid medium to enhance the inherent cavitation or photothermal ablation mechanism for stone ablation during another critical clinical procedure, called pop-dusting, so that the treatment efficiency can be improved, while the procedure time and potentially collateral tissue damage will be reduced. The RP will be led by Po-Chun Hsu, a promising junior investigator new to USD research with expertise in nanotechnology for heat and thermal management that will be central to the RP's strategy. The primary goal of Duke FORWARD's Administrative Core (AC) is to guide and support the efforts of the Center's RP Team to successfully conduct their project and help prepare them to apply for future R01s. The Specific Aims of the AC are to: (1) Facilitate productive collaborations among the RP Team and with the broader CAIRIBU research community; and (2) implement a career development plan for RP PI Po-Chun Hsu for him to gain experience and mastery in USD research knowledge and technical capabilities. If the aims of the AC are achieved, the RP Team will have successfully accomplished the aims of their RP and will be in a position to submit one or more follow-on R01s by Year 3 of the proposed Center. In supporting the Center, the AC will facilitate innovative research with the potential to benefit millions of USD patients worldwide and will have introduced this talented new USD research team to the NIDDK-sponsored CAIRIBU benign urology research community.

行政核心 (AC) 项目摘要/摘要 尿路结石病 (USD) 是美国第二大昂贵的泌尿系统疾病，每年需要接受医疗保健 开支超过20亿美元。通过激光碎石术 (LL) 进行输尿管镜检查 (URS) 是以下疾病的首选治疗方法 美元。最近，推出高功率/高频钬（Ho）：YAG激光器和铥光纤 激光 (TFL) 从根本上改变了 LL 的临床手术模式。当代 LL 经常表演 使用喷粉和弹出喷粉模式，将石头原位粉碎成灰尘，无需提取碎片。 然而，开发能够解决除尘挑战的一些方法的需求尚未得到满足。 和喷洒，以显着改善临床治疗结果，无论结石成分如何， 缩短手术时间，降低组织损伤的风险。拟议的 Duke FORWARD P20 泌尿科 中心（杜克 FORWARD 中心）将解决用 LL 治疗美元时一些最紧迫的问题。这 中心的研究项目（RP）将侧重于修改流体介质以增强固有的空化或 在另一个关键的临床过程中，光热消融机制用于结石消融，称为流行除尘， 从而提高治疗效率，同时减少手术时间和潜在的附属组织 伤害将会减少。 RP 将由 Po-Chun Hsu 领导，他是一位刚接触 USD 的有前途的初级研究员 具有热和热管理纳米技术专业知识的研究将成为 RP 的核心 战略。杜克 FORWARD 行政核心 (AC) 的主要目标是指导和支持相关工作 中心的 RP 团队成功开展他们的项目并帮助他们为申请未来的 R01 做好准备。 AC 的具体目标是： (1) 促进 RP 团队之间以及与 更广泛的 CAIRIBU 研究社区； (2) 为 RP PI Po-Chun Hsu 实施职业发展计划 让他获得美元研究知识和技术能力的经验和掌握。如果目标是 AC 已实现，RP 团队将成功实现其 RP 目标，并处于有利位置 在拟议中心的第 3 年之前提交一份或多份后续 R01。为了支持该中心，审计委员会将 促进创新研究，有可能造福全球数百万美元患者，并将 将这个才华横溢的新美国研究团队引入 NIDDK 资助的 CAIRIBU 良性泌尿学研究 社区。