Rush Center of Excellence on Disparties in HIV and Aging (CEDHA)

拉什艾滋病毒和老龄化问题卓越中心 (CEDHA)

基本信息

批准号：
9001825
负责人：
Lisa L Barnes
金额：
$ 109.05万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-25 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9001825
关键词：
AIDS/HIV problem Acceleration Accounting Address Affect African American Age Aging Back Basic Science Chicago Clinical Cognitive Communities Comorbidity Competence Consequences of HIV County Hospitals Data Data Set Disease Progression Education Education and Outreach Effectiveness Elderly Ensure Environment Epidemiologic Studies Exercise Fish Oils Future Gender Goals HIV HIV Infections Health Human immunodeficiency virus test Illinois Immune Immunologic Markers Inflammation Institution Instruction Interdisciplinary Study Lead Leadership Lymphocyte Magnetic Resonance Imaging Measures Medicine Mentors Minority Minority Recruitment Motor Oils Performance Persons Pilot Projects Population Positioning Attribute Postdoctoral Fellow Psychosocial Stress Public Health Race Randomized Research Research Infrastructure Research Personnel Research Project Grants Research Subjects Research Training Resources Risk Factors Safety Serum Socioeconomic Status Source Specimen Testing Training and Education Trust Underserved Population Universities age related brain abnormalities career combat community college cooking data sharing design double-blind placebo controlled trial experience graduate student health disparity inflammatory marker infrastructure development innovation interest minority health multidisciplinary novel outreach programs psychosocial racial and ethnic racial difference racial disparity senescence social training opportunity university student

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the Rush Center of Excellence on Disparities in HIV and Aging (Rush CEDHA) is to provide an infrastructure to support collaborative, multidisciplinary epidemiologic research focused on understanding and eliminating racial disparities in the aging-related consequences of HIV. The proposed Center will integrate and centralize minority health and health disparities research into a single interdisciplinary and trans-disciplinary enterprise. It has four Cores and three related research projects to support the goals of the Center. The Administrative Core will provide scientific leadership to the CEDHA as a whole. The Research Core will collect annual cognitive and motor function data, psychosocial risk factors, co-morbidities, and biospecimens in older adults (>50 years) with and without HIV infection, and compare them to existing data from HIV-uninfected persons age 65-90 matched on race, gender, and socioeconomic status. The data generated by this Core will be used to support two research projects and one pilot project focused on inflammation and immune senescence in HIV. Project 1 will collect MRI data and serum inflammatory markers on subjects from the Research Core, and test hypotheses concerning the relationships among age, race, and inflammation in HIV. Project 2 will measure immune perturbations and markers of immune senescence in lymphocytes to estimate the age-associated acceleration in aging due to HIV, and test the hypothesis that racial differences in immune perturbations lead to early immune senescence in African Americans with HIV. Pilot project 1 will conduct a 12-week, randomized, double-blind, placebo-controlled trial to explore the safety and estimate the effect offish oil to modulate parameters of aging-related inflammation and immune senescence in HIV. The Research Training/Education Core will centralize education efforts in health disparities research and develop a research training component to mentor early career investigators interested in health disparities. The Community Engagement/Outreach Core will provide a wide range of educational programs to support outreach and recruitment of minorities into studies and disseminate research findings back to the communities experiencing the health disparities.

描述（由申请人提供）：艾滋病毒和衰老差异卓越差异中心的总体目标（Rush Cedha）是提供基础设施，以支持协作，多学科的流行病学研究，重点是理解和消除与HIV相关的老年人后果中的种族差异。拟议的中心将将少数民族健康和健康差异研究整合到一个跨学科和跨学科企业中。它有四个核心和三个相关的研究项目，以支持该中心的目标。行政核心将为整个Cedha提供科学领导。研究核心将收集年轻人（> 50岁）的年轻人（> 50岁）的年度认知和运动功能数据，社会心理危险因素和生物环境，并将其与65-90岁的HIV未感染者的现有数据进行比较，以种族，性别和社会经济状况匹配。该核心产生的数据将用于支持两个研究项目和一个针对HIV炎症和免疫衰老的试点项目。项目1将收集MRI数据和血清研究核心受试者的炎症标记，并检验有关HIV年龄，种族和炎症之间关系的假设。项目2将测量淋巴细胞中免疫衰老的免疫扰动和标志物，以估计艾滋病毒引起的年龄相关的衰老加速度，并检验以下假说，即免疫扰动的种族差异会导致非裔美国人患有艾滋病毒的早期免疫衰老。试点项目1将进行为期12周的，随机，双盲，安慰剂对照试验，以探索安全性并估算抗油的效果，以调节HIV中与衰老相关的炎症和免疫衰老的参数。研究培训/教育核心将集中在健康差异研究中的教育工作，并开发研究培训部分，以指导对健康差异感兴趣的早期职业研究者。社区参与/推广核心将提供广泛的教育计划，以支持少数民族的外展和招募研究，并将研究结果传播回经历健康差异的社区。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Risk and protective factors for health-related quality of life among persons aging with HIV.

DOI：
10.1080/09540121.2017.1381333
发表时间：
2018-04
期刊：
AIDS care
影响因子：
1.7
作者：
Nguyen AL;McNeil CJ;Han SD;Rhodes SD
通讯作者：
Rhodes SD

Neopterin is associated with hippocampal subfield volumes and cognition in HIV.

DOI：
10.1212/nxi.0000000000000467
发表时间：
2018-07
期刊：
Neurology(R) neuroimmunology & neuroinflammation
影响因子：
0
作者：
Fleischman DA;Arfanakis K;Leurgans S;Keating SM;Lamar M;Bennett DA;Adeyemi OM;Barnes LL
通讯作者：
Barnes LL

Racial Differences in the Effect of HIV Status on Motor and Pulmonary Function and Mobility Disability in Older Adults.

DOI：
10.1007/s40615-021-01126-0
发表时间：
2022-10
期刊：
Journal of racial and ethnic health disparities
影响因子：
3.9
作者：
Lange-Maia BS;Buchman AS;Leurgans SE;Lamar M;Lynch EB;Erlandson KM;Barnes LL
通讯作者：
Barnes LL

Association of cognitive activity and neurocognitive function in blacks and whites with HIV.

DOI：
10.1097/qad.0000000000001316
发表时间：
2017-01-28
期刊：
AIDS (London, England)
影响因子：
0
作者：
Krueger KR;Adeyemi O;Leurgans S;Shah RC;Jimenez AD;Ouellet L;Landay AL;Bennett DA;Barnes LL
通讯作者：
Barnes LL

Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial.