AIDS and Cancer Specimen Resource (ACSR)

艾滋病和癌症样本资源 (ACSR)

基本信息

批准号：
8920521
负责人：
MICHAEL Shannon MCGRATH
金额：
$ 423.49万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-23 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8920521
关键词：
AIDS/HIV problem Acceleration Accounting Acquired Immunodeficiency Syndrome Address Arizona Basic Science Behavioral Biological Biological Markers Biological Preservation Cause of Death Clinical Clinical Data Clinical Research Collection Communities Complement Consultations DNA Library Data Coordinating Center Developing Countries Development Diagnosis Ensure Epidemic Epidemiologic Studies Epidemiology Equipment and supply inventories Foundations Funding Future Goals Grant HIV HIV Infections HIV Seropositivity Image Incidence Individual Industry Institutes Institution Instruction Interdisciplinary Study International Investigation Kaposi Sarcoma Laboratories Leadership Liquid substance Maintenance Malignant Neoplasms Malignant neoplasm of lung Medicine Methods Mission National Cancer Institute Non-Hodgkin&apos s Lymphoma Pathogenesis Patients Population Positioning Attribute Procedures Process Program Evaluation Research Research Infrastructure Research Personnel Resources Role Sampling Scientist Services Silver Slide Specimen Staining method Stains Structure System Technology Time TimeLine Tissue Microarray Tissues Training Translational Research Translations Tumor Tissue United States Universities Validation Washington Work base behavioral study biobank cancer specimen resource cancer therapy college drug development experience improved innovation insight interest meetings multidisciplinary new technology novel novel diagnostics novel strategies novel therapeutic intervention operation programs prospective public health relevance repository response sample collection success therapeutic target trend tumor virtual web site

项目摘要

DESCRIPTION (provided by applicant): The National Cancer Institute (NCI) established the AIDS and Cancer Specimen Resource (ACSR) in 1994 to support the collection and expert preservation of clinically-annotated biospecimens for multidisciplinary research, bridging laboratory basic science with clinical, behavioral, and epidemiological studies. For the past 19 years, the ACSR has provided the foundation for successful translational research reliant on consistent access to high-quality well-annotated biospecimens. It has accomplished this via development of extensive expertise in methods for specimen collection and maintenance including specimen stability and full functionality overtime. The ACSR remains crucial to HIV-translational research, expanding services to researchers, and instituting practices to complement innovative new experimental directions by global HIV investigators. Since 2008, the current grant cycle, ACSR banked over 50,000 and distributed over 10,000 biospecimens to scientists worldwide. ACSR has also developed unique programs, offering project consultation and researcher training at all levels that assist with specimen choice and inform about biorepository procedures, thus ensuring appropriate handling and use of valuable biospecimens for research. The work accomplished under the current ACSR will be leveraged and transitioned to achieve the Specific Aims for the new ACSR to: 1) develop and maintain the ACSR infrastructure that allows efficient translation of the overall ACSR mission (to support current and future trends in HIV/AIDS malignancy research) to an ongoing functional program 2) provide scientific leadership, expand utilization and relevance of the resource; 3) acquire, maintain and distribute a diverse collection of high-quality and well-annotated biospecimens and; 4) support initiatives, projects, programs and collections, both national and international through ACSR services. To accomplish these aims we will restructure the current ACSR to a single multisite ACSR, under the direction of the Office of the Chairs (OC) and administered by the Central Operations and Data Coordinating Center (CODCC) to be led by senior investigators in a shared leadership role, Drs. Michael McGrath and Sylvia Silver, representing the continuing UCSF and George Washington University (GW) Regional Biospecimen Repositories (RBR). The two original RBRs, UCSF and GW, account for > 80% of the overall ACSR inventory (500,000+ specimens) and for supplying 90% of the specimens disbursed to researchers in the past five years. The proposed ACSR also will add value through transitioning affiliate programs at the University of Arizona, Tucson, and Baylor College of Medicine to new RBRs. The ACSR will continue to evolve and streamline operations to incorporate a state of the art inventory system, and new technologies and methods to improve specimen viability. The ACSR is a dynamic entity that has used innovative and novel approaches to meet changes in the epidemic and research directions, and is well positioned to continue support of current and future trends in HIV research that will have a positive impact on diagnosis and management of HIV-malignancies worldwide.

描述（由申请人提供）：国家癌症研究所（NCI）于1994年建立了艾滋病和癌症标本资源（ACSR），以支持和专家保存多学科研究的临床注释的生物测量，将实验室基础科学与临床，行为，行为和流行病学研究融合在一起。在过去的19年中，ACSR为成功的转化研究提供了基础，该研究依赖于始终获得高质量的良好批准的生物测量。它通过开发广泛的标本收集和维护方法的专业知识来实现这一目标，包括标本稳定性和全部功能加班。 ACSR对于艾滋病毒翻译研究，扩大对研究人员的服务以及制定实践以补充全球艾滋病毒研究者的创新新实验指导仍然至关重要。自2008年以来，当前的赠款周期以来，ACSR存储了超过50,000，并向全球科学家分发了10,000多个生物测量。 ACSR还开发了独特的计划，在各个级别提供项目咨询和研究人员培训，以帮助标本选择并告知生物措施程序，从而确保适当的处理和使用有价值的生物测量来进行研究。 The work accomplished under the current ACSR will be leveraged and transitioned to achieve the Specific Aims for the new ACSR to: 1) develop and maintain the ACSR infrastructure that allows efficient translation of the overall ACSR mission (to support current and future trends in HIV/AIDS malignancy research) to an ongoing functional program 2) provide scientific leadership, expand utilization and relevance of the resource; 3）获取，维护和分发多种高质量和宣布良好的生物测量的集合； 4）通过ACSR服务，国家和国际的支持计划，项目，计划和收藏。为了实现这些目标，我们将在椅子办公室（OC）的指导下将当前的ACSR重组为单个多站点ACSR，并由中央运营和数据协调中心（CODCC）管理，由高级调查员在共同的领导角色中领导。迈克尔·麦格拉思（Michael McGrath）和西尔维亚·西尔（Sylvia Silver），代表持续的UCSF和乔治华盛顿大学（GW）区域生物传播存储库（RBR）。 UCSF和GW的两个原始RBR占总ACSR库存的80％（500,000以上的标本），并且在过去五年中向研究人员支付了90％的标本。拟议的ACSR还将通过在亚利桑那大学，图森大学和贝勒医学院的过渡会员计划中提高价值。 ACSR将继续发展和简化操作，以结合最先进的库存系统，以及提高标本生存能力的新技术和方法。 ACSR是一个动态的实体，它使用创新和新颖的方法来满足流行病和研究方向的变化，并且可以很好地支持HIV研究中当前和未来趋势的支持，这将对全球HIV-MALIGNANCES的诊断和管理产生积极影响。