Rush Center of Excellence on Disparties in HIV and Aging (CEDHA)

拉什艾滋病毒和老龄化问题卓越中心 (CEDHA)

• 批准号: 8263861
• 负责人: Lisa L Barnes
• 金额: $ 126.71万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-25 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8263861
• 关键词: AIDS/HIV problem; Acceleration; Accounting; Address; Affect; African American; Age; Aging; Back; Basic Science; Brain; Chicago; Clinical; Cognitive; Commit; Communities; Comorbidity; Competence; Consequences of HIV; County Hospitals; Data; Data Set; Disease Progression; Education; Education and Outreach; Effectiveness; Elderly; Ensure; Environment; Epidemiologic Studies; Exercise; Fish Oils; Future; Gender; Goals; HIV; HIV Infections; Health; Human immunodeficiency virus test; Illinois; Immune; Immunologic Markers; Inflammation; Institution; Instruction; Interdisciplinary Study; Lead; Leadership; Lymphocyte; Magnetic Resonance Imaging; Measures; Medicine; Mentors; Minority; Motor; Oils; Performance; Persons; Pilot Projects; Population; Positioning Attribute; Postdoctoral Fellow; Psychosocial Stress; Public Health; Race; Randomized; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Subjects; Research Training; Resources; Risk Factors; Safety; Serum; Socioeconomic Status; Source; Specimen; Testing; Training; Training and Education; Trust; Underserved Population; Universities; age related; career; combat; cooking; data sharing; design; double-blind placebo controlled trial; experience; graduate student; health disparity; inflammatory marker; infrastructure development; innovation; interest; minority health; multidisciplinary; novel; outreach; programs; psychosocial; racial and ethnic; racial difference; senescence; social; university student

DESCRIPTION (provided by applicant): The overall goal of the Rush Center of Excellence on Disparities in HIV and Aging (Rush CEDHA) is to provide an infrastructure to support collaborative, multidisciplinary epidemiologic research focused on understanding and eliminating racial disparities in the aging-related consequences of HIV. The proposed Center will integrate and centralize minority health and health disparities research into a single interdisciplinary and trans-disciplinary enterprise. It has four Cores and three related research projects to support the goals of the Center. The Administrative Core will provide scientific leadership to the CEDHA as a whole. The Research Core will collect annual cognitive and motor function data, psychosocial risk factors, co-morbidities, and biospecimens in older adults (>50 years) with and without HIV infection, and compare them to existing data from HIV-uninfected persons age 65-90 matched on race, gender, and socioeconomic status. The data generated by this Core will be used to support two research projects and one pilot project focused on inflammation and immune senescence in HIV. Project 1 will collect MRI data and serum inflammatory markers on subjects from the Research Core, and test hypotheses concerning the relationships among age, race, and inflammation in HIV. Project 2 will measure immune perturbations and markers of immune senescence in lymphocytes to estimate the age-associated acceleration in aging due to HIV, and test the hypothesis that racial differences in immune perturbations lead to early immune senescence in African Americans with HIV. Pilot project 1 will conduct a 12-week, randomized, double-blind, placebo-controlled trial to explore the safety and estimate the effect offish oil to modulate parameters of aging-related inflammation and immune senescence in HIV. The Research Training/Education Core will centralize education efforts in health disparities research and develop a research training component to mentor early career investigators interested in health disparities. The Community Engagement/Outreach Core will provide a wide range of educational programs to support outreach and recruitment of minorities into studies and disseminate research findings back to the communities experiencing the health disparities.

描述（由申请人提供）：拉什艾滋病毒和老龄化差异卓越中心 (Rush CEDHA) 的总体目标是提供基础设施来支持协作、多学科流行病学研究，重点是了解和消除老龄化相关疾病中的种族差异艾滋病毒的后果。拟议的中心将把少数民族健康和健康差异研究整合并集中到一个跨学科和跨学科的机构中。它有四个核心和三个相关研究项目来支持该中心的目标。行政核心将为整个 CEDHA 提供科学领导。研究核心将收集感染或未感染 HIV 的老年人（> 50 岁）的年度认知和运动功能数据、心理社会风险因素、合并症和生物样本，并将其与 65 岁至未感染 HIV 的现有数据进行比较。 90 人的种族、性别和社会经济地位相匹配。该核心生成的数据将用于支持两个研究项目和一个专注于艾滋病毒炎症和免疫衰老的试点项目。项目1将收集MRI数据和血清 研究核心的受试者的炎症标记物，并测试有关艾滋病毒年龄、种族和炎症之间关系的假设。项目 2 将测量淋巴细胞中的免疫扰动和免疫衰老标志物，以估计 HIV 导致的与年龄相关的衰老加速，并检验免疫扰动的种族差异导致感染 HIV 的非裔美国人早期免疫衰老的假设。试点项目 1 将进行为期 12 周的随机、双盲、安慰剂对照试验，以探索鱼油调节 HIV 中与衰老相关的炎症和免疫衰老参数的安全性并评估其效果。研究培训/教育核心将集中于健康差异研究的教育工作，并开发研究培训部分，以指导对健康差异感兴趣的早期职业研究人员。社区参与/外展核心将提供广泛的教育计划，以支持外展和招募少数族裔参与研究，并将研究成果传播回经历健康差距的社区。