The Sixth International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems

第六届国际骨免疫学会议：免疫与骨骼系统的相互作用

• 批准号: 9117878
• 负责人: MARK C HOROWITZ
• 金额: $ 1.5万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9117878
• 关键词: Achievement; Area; Bone Marrow; Bone Resorption; Cell Lineage; Cell physiology; Cells; Collaborations; Communication; Crete; Development; Discipline; Disease; Engraftment; Faculty; Goals; Greece; Health; Hematologist; Hematopoietic; Hematopoietic System; Hematopoietic stem cells; Homeostasis; Immune; Immune system; Immunologist; International; Marrow; Mediator of activation protein; Osteoblasts; Osteoclasts; Participant; Research; Research Personnel; Scientist; Senior Scientist; Skeletal system; Structure; bone; bone cell; cytokine; meetings; member; osteoimmunology; public health relevance; skeletal; stem cell niche; success; symposium

 DESCRIPTION (provided by applicant): It is now well accepted that the immune, hematopoietic and skeletal systems have major interactions, which occur for the most part, between the bone and bone marrow. Osteoclasts, the cells that resorb bone, are important cellular mediators of skeletal homeostasis and are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines, which were first shown to regulate immune cell function, are now known to regulate bone cells and influence skeletal health. Conversely, cells in the osteoblast lineage and their cytokines are critical for the development of the hematopoietic stem cell niche and the normal development of the hematopoietic and immune cell lineages. Up until recently, scientists involved in immune or bone cell research rarely interacted in a significant way because each discipline developed independently and, for the most part, has remained separate. The fundamental hypothesis of the organizers of this conference is that progress in the field of osteoimmunology, which is the study of the interactions of bone, hematopoietic and immune cells in health and disease, will be delayed unless better communication is established between bone biologists, hematologist and immunologists. The goal of The Sixth International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems is to bring together scientists from these fields in a setting that will facilitate, interactions and new collaborations and hasten progress towards understanding the interconnections of the immune, hematopoietic and skeletal system. Our five previous meetings were highly successful and well attended by 100-150 participants from all over the world.

 描述（由申请人提供）：现在人们普遍认为，免疫、造血和骨骼系统之间存在主要的相互作用，这种相互作用大部分发生在骨和骨髓之间。破骨细胞是吸收骨的细胞，是重要的细胞介质。骨骼稳态的细胞因子来源于造血前体细胞，也能产生免疫细胞。此外，许多细胞因子最初被证明可以调节免疫细胞功能，现在已为人所知。为了调节骨细胞并影响骨骼健康，成骨细胞谱系中的细胞及其细胞因子对于造血干细胞生态位的发育以及造血和免疫细胞谱系的正常发育至关重要。骨细胞研究很少以显着的方式相互作用，因为每个学科都是独立发展的，并且在很大程度上仍然是独立的，本次会议组织者的基本假设是骨免疫学领域的进展，骨免疫学是研究骨细胞的领域。除非骨生物学家、血液学家和免疫学家之间建立更好的沟通，否则骨骼、造血和免疫细胞在健康和疾病中的相互作用将会被推迟。第六届国际骨免疫学会议的目标是：免疫和骨骼系统的相互作用。将来自这些领域的科学家聚集在一起，促进互动和新的合作，并加快了解免疫、造血和骨骼系统之间的相互关系的进展。我们之前的五次会议非常精彩。来自世界各地的 100-150 名参与者成功参加了此次活动。