The Fifth International Conference on Osteoimmunology: Interactions of the Immune

第五届国际骨免疫学会议：免疫的相互作用

• 批准号: 8709156
• 负责人: MARK C HOROWITZ
• 金额: $ 1.5万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8709156
• 关键词: Achievement; Area; Bone Resorption; Cell Lineage; Cell physiology; Cells; Collaborations; Communication; Crete; Development; Discipline; Disease; Engraftment; Faculty; Goals; Greece; Health; Hematologist; Hematopoietic; Hematopoietic System; Hematopoietic stem cells; Homeostasis; Immune; Immune system; Immunologist; International; Marrow; Mediator of activation protein; Osteoblasts; Osteoclasts; Participant; Research; Research Personnel; Scientist; Senior Scientist; Skeletal system; Structure; System; Trees; bone; bone cell; cytokine; meetings; member; public health relevance; skeletal; stem cell niche; success; symposium

DESCRIPTION (provided by applicant): It is now well accepted that the immune, hematopoietic and skeletal systems have major interactions. Osteoclasts, the cells that resorb bone, are important cellular mediators of skeletal homeostasis and are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines, which were first shown to regulate immune cell function, are now known to regulate bone cells and influence skeletal health. Conversely, cells in the osteoblast lineage and their cytokines are critical for the development of the hematopoietic stem cell niche and the normal development of the hematopoietic and immune cell lineages. Up until recently, scientists involved in immune or bone cell research rarely interacted in a significant way because each discipline developed independently and, for the most part, has remained separate. The fundamental hypothesis of the organizers of this conference is that progress in the field of osteoimmunology, which is the study of the interactions of bone, hematopoietic and immune cells in health and disease, will be delayed unless better communication is established between bone biologists, hematologist and immunologists. The goal of The Fifth International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems" is to bring together scientists from these fields in a setting that will facilitate, interactions, new collaborations and hasten progress towards understanding the interconnections of the immune, hematopoietic and skeletal system. Our four previous meetings were extremely well attended and highly successful. 115- 150 participants from all over the world attended each meeting.

描述（由申请人提供）：现在被公认的是免疫，造血和骨骼系统具有主要相互作用。破骨细胞是吸收骨的细胞，是骨骼稳态的重要细胞介质，源自造血前体，也会引起免疫细胞。此外，已知许多首先证明可以调节免疫细胞功能的细胞因子可以调节骨细胞并影响骨骼健康。相反，成骨细胞谱系中的细胞及其细胞因子对于造血干细胞生态位的发育以及造血和免疫细胞谱系的正常发育至关重要。直到最近，参与免疫或骨细胞研究的科学家很少以很大的方式相互作用，因为每个学科都独立发展，并且在大多数情况下都保持了分开。这次会议组织者的基本假设是，除非对骨骼，造血和免疫细胞在健康和疾病中的相互作用的研究领域的进展，否则除非在骨生物学家，血液学家和免疫学家之间建立更好的交流。第五次国际骨气免疫学会议的目标：免疫和骨骼系统的相互作用”是为了将这些领域的科学家汇集在一起​​，以促进，互动，新的合作，并加速进步，以理解免疫，造血和骨骼系统的相互联系，我们的四个会议都非常成功。