Prevention of Lower Urinary Tract Symptoms in Women: Yale Bladder Health Clinical Center

预防女性下尿路症状：耶鲁膀胱健康临床中心

• 批准号: 9124872
• 负责人: Leslie M. Rickey
• 金额: $ 51.33万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9124872
• 关键词: Accounting; Address; Adolescent; Adult; Affect; Age; American; Animals; Area; Award; Behavior; Behavioral; Biological Factors; Bladder; Cardiovascular Diseases; Caring; Child; Childhood; Chronic; Chronic Disease; Clinic; Clinical; Clinical Sciences; Cohort Studies; Collaborations; Communities; Comorbidity; Complex; Data; Data Set; Databases; Development; Diabetes Mellitus; Diet; Disease; Ecosystem; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Epigenetic Process; Event; Exposure to; Faculty; Family; Female; Focus Groups; Frequencies; Functional disorder; Future; Gene Expression; Genome; Goals; Habits; Health; Health Services; Health behavior; Health education; Human; Individual; Individual Differences; Infection; Insurance; Intake; Intervention; Intervention Studies; Knowledge; Lead; Life; Light; Liquid substance; Longevity; Longitudinal Studies; Lower urinary tract; Measures; Medical; Menopause; Mental Depression; Modeling; Modification; Morbidity - disease rate; NCI Scholars Program; Neurophysiology - biologic function; Obesity; Occupational; Occupations; Outcome; Pain; Patients; Persons; Physical activity; Physiology; Plant Roots; Population; Population Growth; Pregnancy; Prenatal care; Prevalence; Prevention; Prevention strategy; Preventive Intervention; Primary Health Care; Primary Prevention; Productivity; Psychosocial Factor; Public Health; Publishing; Quality of life; Records; Recruitment Activity; Research; Research Design; Research Personnel; Risk; Risk Factors; Science; Scientist; Secondary Prevention; Severities; Signal Transduction; Smoking; Societies; Stress; Surveys; Symptoms; Systems Theory; Teenagers; Training; Translational Research; United States; United States National Institutes of Health; Urinary tract infection; Vaccination; Woman; Wood material; age group; base; behavior change; clinical investigation; contextual factors; cost; design; disability; disorder prevention; evidence base; experience; falls; girls; health literacy; high risk; improved; innovation; insight; knowledge base; lifestyle factors; longitudinal database; lower urinary tract symptoms; modifiable risk; multidisciplinary; peer; programs; prospective; psychosocial; reproductive; social; socioeconomics; trait

 DESCRIPTION (provided by applicant): Lower urinary tract dysfunction (LUTD) includes symptoms related to bladder storage, emptying, pain, and infection. LUTD is a highly prevalent chronic medical condition that disproportionately affects women and contributes to overall morbidity. Based on population growth and prevalence estimates, lower urinary tract symptoms (LUTS) and conditions are expected to affect more than 43 million women over the next 30 years. The cost to society for LUTS and related issues such as falls and lost productivity is estimated to be over $65 billion per year. LUTS also interfere with participation in social and physical activities, which affects quality of life and also contributes negatively to other chronic medical conditions such as cardiovascular disease, diabetes, obesity, and depression. Clearly, there is high individual and societal impact, however many women do not understand these implications, and even symptomatic women often don't seek treatment. This is likely due to a focus on disease treatment without adequate understanding of what behaviors affect LUTS development and progression. The PLUS consortium will establish the evidence base necessary to conduct future prevention intervention studies in girls and women. The objective of our application is to demonstrate how we can build the knowledge base for bladder health using Ecological Systems Theory as a guiding framework, an approach that addresses risk factors at the individual, family/peer, and community levels. Health outcomes are affected by a variety of complex and interrelated factors both at the individual and environmental level. The majority of current evidence for bladder health and risk factors for LUTS is based on individual traits, and therefore most interventions have focused on a single stratum of the ecologic model without consideration of contextual targets within other levels. Utilizing existing databases, focus groups, and longitudinal cohort studies, we will consider issues including biologic factors, behaviors, knowledge, environment, and health services that will determine who is at risk to develop LUTS and how early symptoms are addressed and managed. A multi-level approach is essential to any sustainable, effective program; hence, an ecological framework that accounts for multiple contextual factors is critical to identifying and ultimately changing behaviors that lad to LUTS and associated health outcomes. The multidisciplinary team we have assembled for the Yale Bladder Health Clinical Center includes experts in LUTS care and research in addition to investigators with expertise in health behaviors and epidemiologic studies across the age range of females including smoking, vaccination, obesity, prenatal care, urinary tract infection, and disability. Investigators have recruited female patients both from primary care clinics and the community into numerous longitudinal studies, and their approach to chronic disease prevention will shed new light on the study of risk and protective factors for LUTS. This innovative collaboration between clinicians and prevention scientists will help redefine LUTS as a public health issue and ultimately improve the long term health and wellness of millions of girls and women.

 描述（通过应用程序证明）：较低的尿道功能障碍（LUTD）包括与膀胱储存有关的症状，疼痛LUTD是一种高度普遍的慢性角色影响，会影响女性，并有助于整体病态。在30年中，条件是30年来的4300万妇女。并贡献其他慢性 诸如心血管疾病，糖尿病和抑郁症之类的医疗状况并不理解这些含义的含义，而没有不够的影响，而不是luts的发展，而Prortib将会有证据表明我们可以在未来的妇女中进行预防。使用系统理论作为指导框架的知识基础，一种解决个人，EER和社区级别的风险因素的方法。 LUTS的风险因素基于在其他级别的收缩靶标的单个层次上使用的单个特征，我们将考虑包含生物学因素，知识，环境的问题发展LUT的风险以及如何增加症状和可持续的生态框架，这些框架是多种上下文因素，对于确定和变化的行为至关重要。包括LUTS护理和研究的专家，除了具有专业知识的研究人员，跨年龄范围内的emales s moking，疫苗，产前护理，尿路感染和残疾人的研究人员都招募了Pri Mary Care Clinics和Thee The The The The The The The The The The The The The The The The The The The The The The The The The The Mary Careils，并许多纵向研究及其对慢性疾病的方法将为LUTS的风险和保护性研究提供新的启示。 和女人。