Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Yale Clinical Research Center

预防下尿路症状 (PLUS) 研究联盟耶鲁临床研究中心

基本信息

批准号：
10053968
负责人：
Leslie M. Rickey
金额：
$ 39.5万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10053968
关键词：
Adaptive Behaviors Adolescent Adult Affect American Behavior Behavioral Behavioral Sciences Belief Bladder Clinical Research Cohort Studies Collaborations Communities Community Outreach Data Daughter Development Ecosystem Environment Environmental Risk Factor Epidemiology Foundations Frequencies Future Goals Health Health Promotion Health Status Health behavior Healthcare Home environment Individual Intake Intervention Studies Life Cycle Stages Liquid substance Lower urinary tract Measurement Measures Methodology Methods Mothers Participant Pelvic Floor Muscle Pilot Projects Policies Positioning Attribute Prevention Prevention Research Prevention program Prevention strategy Preventive Intervention Primary Health Care Primary Prevention Public Health Publications Research Research Personnel Risk Factors Schools Science Scientist Secondary Prevention Shapes Strategic Planning Systems Theory Time Training United States Woman Women&apos s Health Work clinical center clinical investigation clinical practice cohort community based participatory research design economic implication environmental change evidence base experience girls improved innovation lower urinary tract symptoms population based prevent prevention evaluation protective factors protocol development social social factors social implication symposium young woman

项目摘要

1 Lower urinary tract symptoms (LUTS) are highly prevalent among women in the United States (US) with 2 profound health, social, and economic implications. However many women do not understand these health 3 consequences, and even symptomatic women often do not seek treatment. A majority of LUTS research and 4 clinical practice has focused on treatment of the most affected subset of women; thus the evidence base for 5 prevention is sparse. An improved understanding of risk and protective factors for LUTS development in 6 women across the life course is essential to inform the development and evaluation of prevention interventions. 7 The goal of the Prevention of Lower Urinary Tract Symptoms (PLUS) Consortium is to conduct collaborative, 8 transdisciplinary studies to establish the evidence base for future intervention studies to promote bladder 9 health and prevent LUTS in adolescent and adult women. The Yale Clinical Research Center has substantively 10 contributed to this effort over the last 4 years by engaging in—and leading—PLUS foundational work including 11 the development of a conceptual framework, formative qualitative and quantitative research, strategic planning, 12 measure- and protocol-development, and the active engagement of communities of scientists, clinicians, and 13 the lay public through publications, conference presentations, and community outreach efforts. We are ideally 14 positioned to continue impactful contributions to PLUS research initiatives in the next cycle, bringing deep 15 experience and expertise in behavioral science, conceptualizing and designing large cohort studies, and 16 engaging diverse community participants to inform prevention research. 17 Drawing on ecological systems theory and using the PLUS Consortium conceptual framework, we will conduct 18 transdisciplinary prevention research that investigates multiple levels of influence on individuals’ bladder- 19 related behaviors and bladder health across the life course. Our aims are to: (1) Actively contribute to the 20 conceptualization, design, and implementation of a longitudinal national, population-based observational cohort 21 study examining women’s bladder health across the life course; (2) Analyze data from the national cohort study 22 to identify individual, social, and environmental factors associated with toileting behavior (e.g., frequency, 23 position, avoidance), the onset and use of adaptive behaviors (e.g., modifying activities and fluids, use of 24 absorptive products, pelvic floor muscle training, health care or information seeking), and subsequent bladder 25 health status over time; and (3) Conduct a mixed methods pilot study to determine how home and school 26 environments influence adolescent women’s toileting beliefs, behaviors, and bladder health status and identify 27 opportunities for behavioral and environmental changes that can help plan future intervention studies. This 28 innovative approach will assess social ecological factors that promote bladder health and contribute to LUTS 29 initiation and progression. Findings will be used to inform preventative strategies that will ultimately help reduce 30 the burden of LUTS and promote bladder health in adolescent and adult women.

1 下尿路症状 (LUTS) 在美国 (US) 女性中非常普遍 2 深远的健康、社会和经济影响然而许多女性并不了解这些健康问题。 3 后果，甚至有症状的女性也常常不寻求治疗大多数LUTS研究表明。 4 临床实践重点关注受影响最大的女性群体的治疗，因此为以下方面提供了证据基础： 5 对 LUTS 发展的风险和保护因素的了解很少。 6 妇女在整个生命过程中对于预防干预措施的制定和评估至关重要。 7 下尿路症状预防 (PLUS) 联盟的目标是开展协作、 8项跨学科研究为未来促进膀胱的干预研究奠定基础证据 9 健康和预防青少年和成年女性的 LUTS 耶鲁大学临床研究中心已取得实质性成果。 10 在过去 4 年里，通过参与并领导 PLUS 基础工作，为这项工作做出了贡献，其中包括 11 制定概念框架、形成性定性和定量研究、战略规划、 12 措施和协议的制定，以及科学家、信徒和社会团体的积极参与 13 通过出版物、会议演讲和社区外展活动向公众开放我们是理想的。 14 致力于在下一个周期继续为 PLUS 研究计划做出有影响力的贡献，带来深刻的影响 15 在行为科学、概念化和设计大型队列研究方面的经验和专业知识，以及 16 让不同的社区参与者参与进来，为预防研究提供信息。 17 借鉴生态系统理论并使用 PLUS Consortium 概念框架，我们将开展 18 项跨学科预防研究调查了对个人膀胱的多层次影响整个生命过程中的 19 种相关行为和膀胱健康我们的目标是： (1) 积极促进 20 基于人口的全国纵向观察队列的概念化、设计和实施 21 研究检查女性整个生命过程中的膀胱健康状况；(2) 分析国家队列研究的数据； 22 识别与如厕行为相关的个人、社会和环境因素（例如频率、 23 姿势、回避）、适应性行为的发生和使用（例如，改变活动和液体、使用 24 吸收性产品、盆底肌肉训练、保健或信息寻求），以及随后的膀胱 25 一段时间内的健康状况；以及 (3) 进行混合方法试点研究，以确定家庭和学校的情况 26 种环境影响青春期女性的如厕信念、行为和膀胱健康状况，并确定 27 行为和环境改变的机会可以帮助规划未来的干预研究。 28 种创新方法将评估促进膀胱健康和导致 LUTS 的社会生态因素 29 调查结果将用于指导预防策略，最终有助于减少。 30 减轻 LUTS 的负担并促进青少年和成年女性的膀胱健康。