Nebraska Center for Integrated Biomolecular Communication (CIBC)

内布拉斯加州综合生物分子通讯中心 (CIBC)

• 批准号: 8813076
• 负责人: JAMES M TAKACS
• 金额: $ 221.28万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813076
• 关键词: Address; Advanced Development; Biochemistry; Bioinformatics; Biological Sciences; Biomedical Research; Cells; Centers of Research Excellence; Chemicals; Chemistry; Collaborations; Communication; Communication Research; Communities; Complex; Computer Simulation; Core Facility; Coupled; Data; Data Analyses; Development; Disease; Disease Pathway; Disease Progression; Engineering; Fostering; Goals; Human; Human Resources; Individual; Informatics; Interdisciplinary Study; International; Kinetics; Knowledge; Lead; Ligands; Liver; Liver diseases; Mass Spectrum Analysis; Metabolic; Metabolic Pathway; Metagenomics; Methodology; Methods; Microscopy; Molecular; Molecular Probes; Mutation; NMR Spectroscopy; Nature; Nebraska; Organism; Outcome; Pathway interactions; Phosphorylation; Protein Analysis; Proteins; Proteomics; Regulation; Regulatory Pathway; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resolution; Science; Services; Signal Transduction; Staging; Stimulus; Structure; System; Systems Biology; Techniques; Technology; Tissue Engineering; Tissues; Universities; career development; cohort; data management; design; environmental chemical; improved; innovation; meetings; member; metabolomics; microbial; nature center; new technology; next generation sequencing; novel; pathogen; protein profiling; public health relevance; rapid technique; research and development; response; success; temporal measurement; tool

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln (UNL) seeks to foster collaborative interdisciplinary research to enhance its biomedical research infrastructure in the molecular life sciences. Building on the success of two prior UNL Centers of Biomedical Research Excellence (COBREs), it is proposed to establish the Nebraska Center for Integrated Biomolecular Communication (CIBC). The proper regulation of biomolecular communication pathways is critical to maintaining healthy function, yet there are many gaps in the fundamental understanding of those pathways. Unraveling those pathways and filling in critical knowledge gaps requires the combined expertise of collaborative, interdisciplinary research teams. CIBC's long-term goal is to foster the development of collaborative research teams with broad disciplinary representation to interrogate complex disease pathways, especially by connecting researchers who are developing new molecular probes and analytical techniques with those unravelling molecular mechanisms of complex diseases. CIBC's Specific Aims are to: 1) Support the research and career development of early stage investigators whose research is broadly focused on understanding the regulation of biomolecular communication pathways; 2) Leverage existing facilities and enhance research capabilities by establishing a Systems Biology Core and a Data Management and Analysis Core; and 3) Foster the development of integrated interdisciplinary research collaborations with diverse disciplinary representation to pursue high impact biomedical research. The initial cohort of project leaders - five early stage investigators from the Departments of Biochemistry, Chemistry, and Chemical and Biomolecular Engineering - are pursuing projects interrelated by their fundamental focus on different aspects of biomolecular communication within and between cells and tissues. These projects are directed toward identifying molecular metabolic signals of microbial syntrophy in the human gut, developing techniques for high-resolution protein glycoform analysis, unraveling ligand-Stabilin-2 interactions in liver disease progression, designing molecular probes for intracellular phosphorylation kinetics, and developing tissue engineering platforms specifically for liver. The breadth of science encompassed by these projects signifies the interdisciplinary nature of the Center's research goals. CIBC's proposed Systems Biology Core and Data Management and Analysis Core facilities leverage existing core facilities established under prior COBRE support. The proposed research cores, coupled with the interdisciplinary focus of the CIBC, will serve as a natural mixing chamber to foster the development of new collaborations among Nebraska's biomedical researchers to pursue high impact biomedical research. CIBC's innovation is in integrating the research activities of chemists, biochemists, engineers, and bioinformaticists. Its impact will be in addressing critical knowledge gaps in the understanding of how cells communicate and integrate metabolic and regulatory pathways relevant to disease development and progression.

 描述（由申请人提供）：内布拉斯加州林肯大学（UNL）试图培养协作跨学科研究，以增强分子生命科学（COBRES）的生物医学研究基础设施。 （CIBC）。离子途径对主要功能至关重组合特定目的的分子机制是：1）早期研究者的研究，其研究广泛地构成了生物分子通信途径的法规，并通过建立系统生物学核心和Andalyaly Core来增强现有的设施； ）促进综合研究合作，以纪律处分来追求来自生物化学部门的早期研究人员，以及化学和生物分子英语的生物医学研究人员针对人类肠道中微生物综合体的II信号，开发用于高分辨率蛋白质糖型分析的技术，从而揭示了肝病中的配体 - stabilin-2相互作用，desig。这些项目涵盖了专门针对肝脏的平台。 CIBC自然混合室促进了新协作的生物医学研究人员的发展，以追求高影响力的生物医学恢复。 在理解细胞如何沟通和整合与疾病发展和进步有关的新陈代谢和促进的关键差距方面的影响将是在解决关键差距方面的影响。