Nebraska Center for Integrated Biomolecular Communication (CIBC)

内布拉斯加州综合生物分子通讯中心 (CIBC)

• 批准号: 10016339
• 负责人: JAMES M TAKACS
• 金额: $ 228.13万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2021-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10016339
• 关键词: Address; Advanced Development; Biochemistry; Bioinformatics; Biological Sciences; Biomedical Research; Cells; Centers of Research Excellence; Chemicals; Chemistry; Collaborations; Communication; Communication Research; Communities; Complex; Computer Models; Core Facility; Coupled; Data; Data Analyses; Development; Disease; Disease Pathway; Disease Progression; Engineering; Fostering; Goals; Human; Human Resources; Individual; Interdisciplinary Study; International; Kinetics; Knowledge; Lead; Ligands; Liver; Liver diseases; Mass Spectrum Analysis; Metabolic; Metabolic Pathway; Metagenomics; Methodology; Methods; Microscopy; Molecular; Molecular Probes; Mutation; NMR Spectroscopy; Nature; Nebraska; Organism; Outcome; Pathway interactions; Phosphorylation; Protein Analysis; Proteins; Proteomics; Regulation; Regulatory Pathway; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resolution; Science; Services; Signal Transduction; Stimulus; Structure; System; Systems Biology; Techniques; Technology; Tissue Engineering; Tissues; Universities; career development; cohort; data management; design; environmental chemical; improved; informatics tool; innovation; member; metabolomics; microbial; nature center; new technology; next generation sequencing; novel; pathogen; protein profiling; public health relevance; rapid technique; research and development; response; structured data; success; temporal measurement

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln (UNL) seeks to foster collaborative interdisciplinary research to enhance its biomedical research infrastructure in the molecular life sciences. Building on the success of two prior UNL Centers of Biomedical Research Excellence (COBREs), it is proposed to establish the Nebraska Center for Integrated Biomolecular Communication (CIBC). The proper regulation of biomolecular communication pathways is critical to maintaining healthy function, yet there are many gaps in the fundamental understanding of those pathways. Unraveling those pathways and filling in critical knowledge gaps requires the combined expertise of collaborative, interdisciplinary research teams. CIBC's long-term goal is to foster the development of collaborative research teams with broad disciplinary representation to interrogate complex disease pathways, especially by connecting researchers who are developing new molecular probes and analytical techniques with those unravelling molecular mechanisms of complex diseases. CIBC's Specific Aims are to: 1) Support the research and career development of early stage investigators whose research is broadly focused on understanding the regulation of biomolecular communication pathways; 2) Leverage existing facilities and enhance research capabilities by establishing a Systems Biology Core and a Data Management and Analysis Core; and 3) Foster the development of integrated interdisciplinary research collaborations with diverse disciplinary representation to pursue high impact biomedical research. The initial cohort of project leaders - five early stage investigators from the Departments of Biochemistry, Chemistry, and Chemical and Biomolecular Engineering - are pursuing projects interrelated by their fundamental focus on different aspects of biomolecular communication within and between cells and tissues. These projects are directed toward identifying molecular metabolic signals of microbial syntrophy in the human gut, developing techniques for high-resolution protein glycoform analysis, unraveling ligand-Stabilin-2 interactions in liver disease progression, designing molecular probes for intracellular phosphorylation kinetics, and developing tissue engineering platforms specifically for liver. The breadth of science encompassed by these projects signifies the interdisciplinary nature of the Center's research goals. CIBC's proposed Systems Biology Core and Data Management and Analysis Core facilities leverage existing core facilities established under prior COBRE support. The proposed research cores, coupled with the interdisciplinary focus of the CIBC, will serve as a natural mixing chamber to foster the development of new collaborations among Nebraska's biomedical researchers to pursue high impact biomedical research. CIBC's innovation is in integrating the research activities of chemists, biochemists, engineers, and bioinformaticists. Its impact will be in addressing critical knowledge gaps in the understanding of how cells communicate and integrate metabolic and regulatory pathways relevant to disease development and progression.

 描述（由应用程序提供）：内布拉斯加州林肯大学（UNL）试图促进协作跨学科研究，以增强其在分子生命科学中的生物医学研究基础设施。在基于两个先前的生物医学研究卓越中心（Cobres）的成功基础上，建议建立内布拉斯加州综合生物分子通信中心（CIBC）。生物分子通信途径的适当调节对于维持健康的功能至关重要，但是对这些途径的基本理解存在许多差距。解开这些途径并填补关键知识差距，需要协作，跨学科研究团队的综合专业知识。 CIBC的长期目标是促进具有广泛纪律处分的协作研究团队的发展，以询问复杂的疾病途径，尤其是通过将开发新的分子问题和分析技术与复杂疾病的分子机制的研究人员联系起来。 CIBC的具体目的是：1）支持早期研究人员的研究和职业发展，其研究主要集中于了解生物分子交流途径的调节； 2）通过建立系统生物学核心以及数据管理和分析核心来利用现有的设施并增强研究能力； 3）促进与潜水学纪律代表的综合跨学科研究合作的发展，以进行高影响生物医学研究。最初的项目领导者队列 - 来自生物化学，化学，化学和生物分子工程部门的五名早期研究人员正在追求项目，因为他们的基本关注对细胞内部和组织之间的生物分子交流的不同方面相关。这些项目针对人类肠道中微生物综合体的分子代谢信号，开发用于高分辨率蛋白质糖型分析的技术，揭示了肝脏疾病进展中的配体 - stabilin-2相互作用，设计分子问题，为细胞内磷酸化的磷酸化kinetics kinetics intery for Ingressution instue Engineering Platterns for Intelling instue intergection inter Greate for Hange Instelue Plactige for Liver liver。这些项目所包含的科学广度表明该中心研究目标的跨学科性质。 CIBC提出的系统生物学核心和数据管理和分析核心设施利用了在先前的COBRE支持下建立的现有核心设施。拟议的研究核心，再加上CIBC的跨学科重点，将作为自然混合室，以促进内布拉斯加州生物医学研究人员之间新合作的发展，以纯化高影响生物医学研究。 CIBC的创新在于整合化学家，生物化学家，工程师和生物信息学家的研究活动。 在理解细胞如何沟通和整合与疾病发展和进展相关的新陈代谢和调节途径时，影响将解决关键知识差距。