Tai Chi Practice and Sleep-Active Glymphatic Function

太极拳练习和睡眠活跃类淋巴功能

基本信息

批准号：
10583904
负责人：
Jeffrey J Iliff
金额：
$ 49.38万
依托单位：
SEATTLE INST FOR BIOMEDICAL/CLINICAL RES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10583904
关键词：
Abeta clearance Abeta synthesis Affective Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease model Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Alzheimer’s disease biomarker Amyloid beta-Protein Beds Behavior Biological Markers Blood Vessels Brain Breathing Cardiovascular Physiology Cerebrospinal Fluid Cerebrovascular Disorders Chinese Chronic Clinical Clinical Research Clinical Trials Cognition Cognitive Dementia Deposition Development Disease Elderly Enrollment Equilibrium Failure Foundations Frequencies Functional Magnetic Resonance Imaging Future Goals Human Individual Intercellular Fluid Intervention Intervention Trial Longitudinal Studies Magnetic Resonance Imaging Measurable Measurement Measures Modality Moods Motion Movement Outcome Participant Pathologic Pathway interactions Patient Self-Report Physical activity Physiological Physiological Processes Pilot Projects Polysomnography Posture Prevention Primary Prevention Proteins Questionnaires Respiration Respiratory physiology Risk Self Assessment Senile Plaques Sleep Sleep Apnea Syndromes Sleep Fragmentations Sleep disturbances Symptoms Tai Ji Testing Training Vasomotor Ventricular Veterans Water Well in self aging brain blood oxygen level dependent cerebrospinal fluid flow contrast enhanced cost demented experience glymphatic clearance glymphatic dysfunction glymphatic function glymphatic system improved improvement on sleep interest interstitial middle age mindfulness mouse model multimodality novel strategies pressure prevent prospective randomized, clinical trials recruit response secondary analysis sleep quality solute study population tau Proteins wasting

项目摘要

PROJECT SUMMARY/ABSTRACT Amyloid plaque deposition, a key pathological hallmark of Alzheimer’s disease (AD), begins 1-2 decades before manifestation of clinical symptoms of dementia. Among cognitively intact individuals and in AD’s most prevalent sporadic form, the production of amyloid-β (Aβ) does not change, while clearance of Aβ is slowed, indicating that the failure of Aβ clearance may underlie the development of AD pathology and that interventions that improve its clearance may provide an opportunity for primary prevention of AD. Over the past 10 years, our group has helped to define the ‘glymphatic system’, a brain-wide network of perivascular pathways along which cerebrospinal fluid (CSF) surrounding the brain exchanges with brain interstitial fluid, supporting the clearance of interstitial wastes, including Aβ and tau. Impairment of glymphatic clearance is observed in the aging brain and in mouse models of AD. Thus, improving glymphatic clearance of brain interstitial proteins may be one approach to preventing the development of AD. Glymphatic function is regulated by sleep-wake behavior, with faster clearance occurring during sleep. Tai Chi is a Chinese martial art focusing on mindful body movement, posture, and breathing as an avenue to achieve a state of internal balance, calm, and clarity. In clinical studies, practice of Tai Chi is associated with improved sleep quality, cognition, mood, cardiovascular and respiratory function, and balance/physical activity. However, the physiological processes underlying the cognitive and affective effects of Tai Chi remain undefined. We hypothesize that Tai Chi practice improves glymphatic function. To test this hypothesis, we will enroll 75 middle-aged (50-70 years) participants with different levels of Tai Chi practice experience: Tai Chi proficients (10+ year of practice, n=25), Tai Chi beginners (12 months practice, n=25) and Tai Chi naïve participants (n=25). We will 1) examine the association between Tai Chi practice and glymphatic function using multi-modal magnetic resonance imaging (MRI) using contrast-enhanced MRI, T1/FLAIR assessment of MRI-visible perivascular spaces, intravoxel incoherent motion, and fast BOLD-fMRI; 2) examine relationships between Tai Chi practice and sleep, including sleep fragmentation, efficiency, and duration, assessed by self-reported questionnaires and objective measurements of sleep duration, fragmentation and efficiency using a bed pressure mat. We will examine the relationship between sleep measures and MRI-assessed glymphatic function. The ultimate goal of this study is to elucidate mechanisms of Tai Chi practice in prevention of AD and related dementias. This pilot study will determine whether long-term Tai Chi practice is associated with physiological changes in glymphatic function and sleep. If we find cross-sectional association among Tai Chi practice, glymphatic function, and sleep, in the future we will investigate whether these changes are associated with duration of Tai Chi practice and whether these changes are associated with changes in AD biomarkers in a longitudinal study or in a prospective randomized clinical trial.

项目概要/摘要淀粉样斑块沉积是阿尔茨海默病 (AD) 的一个关键病理标志，开始于 1-2 十年在认知能力完好的个体和 AD 患者中，出现痴呆的临床症状之前。流行的散发形式，淀粉样蛋白-β (Aβ) 的产生不会改变，而 Aβ 的清除速度减慢，表明 Aβ 清除失败可能是 AD 病理学发展的基础，并且干预措施在过去的 10 年里，提高其清除率可能为 AD 的一级预防提供机会。我们的小组帮助定义了“类淋巴系统”，这是一个由血管周围通路组成的全脑网络大脑周围的脑脊液（CSF）与脑间质液交换，支持间质废物的清除，包括 Aβ 和 tau 蛋白的清除。因此，改善脑间质蛋白的类淋巴清除率可能会导致大脑老化和 AD 小鼠模型。是预防 AD 发展的一种方法。淋巴功能受睡眠-觉醒调节。太极拳是一种专注于正念的中国武术。身体运动、姿势和呼吸是实现内部平衡、平静和清晰状态的途径。在临床研究中，练习太极拳与改善睡眠质量、认知、情绪、心血管和呼吸功能以及平衡/身体活动然而，生理过程。我们对太极拳练习的认知和情感影响仍不明确。为了验证这一假设，我们将招募 75 名中年（50-70 岁）参与者。具有不同级别的太极拳练习经验：太极拳高手（练习10年以上，n=25）、太极拳初学者（练习 12 个月，n = 25）和太极拳新手（n = 25）我们将 1）检查使用多模态磁共振成像研究太极练习与类淋巴功能之间的关联 (MRI) 使用对比增强 MRI、T1/FLAIR 评估 MRI 可见血管周围空间、体素不连贯的运动和快速 BOLD-fMRI；2）检查太极拳练习与睡眠之间的关系，包括睡眠碎片化、效率和持续时间，通过自我报告的问卷和目标进行评估我们将使用床压垫测量睡眠持续时间、碎片化和效率。睡眠测量与 MRI 评估的类淋巴功能之间的关系这项研究的最终目标是。这项试点研究旨在阐明太极拳练习预防 AD 和相关痴呆症的机制。确定长期太极拳练习是否与类淋巴功能的生理变化有关如果我们发现太极拳练习、类淋巴功能和睡眠之间的横断面关联，未来我们将研究这些变化是否与太极拳练习时间有关，以及是否与太极拳练习时间有关。这些变化与纵向研究或前瞻性研究中 AD 生物标志物的变化相关随机临床试验。