Institute for Clinical and Translational Science

临床与转化科学研究所

• 批准号: 9045749
• 负责人: DAN M COOPER
• 金额: $ 165.67万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9045749
• 关键词: Academic Medical Centers; Address; Adoption; Advocacy; Architecture; Area; Basic Science; Beds; Biological Markers; Biophotonics; California; Cancer Center; Caring; Center for Translational Science Activities; Childhood; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Health; Community Outreach; Computerized Medical Record; Consultations; Data; Data Quality; Dementia; Development; Discipline of Nursing; Distant; Educational process of instructing; Elder Abuse; Engineering; Ensure; Exercise; Faculty; Funding; Generations; Genomics; Goals; Grant; Health; Health Professional; Health Sciences; Heart; Hospitals; Human; Incubated; Individual; Information Sciences; Information Systems; Inpatients; Institutes; Institution; Instruction; Interdisciplinary Study; Laboratories; Leadership; Link; Medical; Medical Students; Medical center; Mentors; Mentorship; Methodology; Mitochondrial Diseases; Molecular; Nanotechnology; Nomenclature; Nurses; Nursing Students; Obesity; Ontology; Operations Research; Ownership; Participant; Phase; Physicians; Population Heterogeneity; Positioning Attribute; Principal Investigator; Process; Public Health; Qualitative Research; Research; Research Infrastructure; Research Personnel; Resources; Robotics; Role; Safety; Schools; Science; Scientist; Security; Seminal; Series; Services; Structure; Students; Sudden Death; Talents; Technology; Testing; Thirst; Training; Translational Research; Underinsured; United States National Institutes of Health; Universities; Vision; Voice; Work; aging brain; authority; base; biomedical informatics; career development; clinical investigation; comparative effectiveness; computer science; data management; design; disease phenotype; effectiveness research; empowered; experience; flexibility; improved; innovation; interoperability; multidisciplinary; new technology; next generation; novel; novel strategies; outreach; prevent; programs; protocol development; remote sensing; response; social; symposium; tool; volatile organic compound; volunteer

Three years ago, UCI created the Institute for Clinical and Translational Science (ICTS), which identifies tests, and implements innovative ways to break down barriers that impede biomedical discovery. In the next phase of our concerted effort to transform the UCI clinical research enterprise, our vision is to: 1) Nurture Novel Collaborations-The ICTS builds multidisciplinary research teams, such as chemists and clinicians exploring breath biomarkers in the human "ventilome." ICTS experts in the science of team science will help new partnerships to identify and remove obstacles to successful collaboration before they become insurmountable. 2) Create New Technologies for Translational Science-The ICTS made novel UCI-based technologies such as biophotonics and microdevices available to a new generation of clinicians. We will now develop and provide new methodologies by partnering with UCI information scientists in the use of ubiquitous computing for field research; with nursing and social scientists for qualitative and comparative effectiveness research; and with exercise physiologists and molecular biologists for technologies that link genomic information with dynamic disease phenotypes. 3) Share Information-The ICTS has engaged clinicians, hospital IT staff, and scholars from the School of Information and Computer Sciences to create the Center for Biomedical Informatics. We are now ready to embed infrastructure for clinical data interoperability at a unique moment, namely, as UCI begins to deploy its EMR; 4) Engage Our Community-The ICTS championed new approaches such as PEER (Participant Experience Enhancement in Research), a program that views research volunteers as partners in the process of discovery. We plan a range of outreach/dissemination activities, from mitigating elder abuse to preventing sudden death in pediatric athletes. And 5) Train-We will implement Crossing Boundaries, a set of degree and certificate programs along with mentorship interaction that tackles key issues in translational science. Finally, we view ourselves as part of a unique translational science network for Southern California, in which the resources of regional academic medical centers are integrated to better realize the overarching vision of the CTSA. RELEVANCE (See Instructions): UCI is becoming a motivating force for clinical research in this dynamic region of Southern California. The ICTS will support a wide range of projects that will benefit public health, including the ambitious NIH-funded National Childen's Study; research into rare, poorly studied diseases of mitochondrial origin; and community outreach efforts to mitigate the health consequences of obesity among underinsured people in our region.

三年前，UCI创建了临床与转化科学研究所（ICT），该研究所确定 测试，并实现创新的方法来打破阻碍生物医学发现的障碍。在下一个 我们共同努力改变UCI临床研究企业的阶段，我们的愿景是：1） 新颖的合作 - ICT建立了多学科研究团队，例如化学家和临床医生 探索人类“通用物”中的呼吸生物标志物。 ICTS科学科学专家将有助于 新的合作伙伴关系，以识别和消除成功合作的障碍 不可逾越。 2）为转化科学创建新技术 - ICT制造了基于UCI的新技术 新一代临床医生可用于生物探测器和微型版本之类的技术。我们现在会 通过与UCI​​信息科学家合作开发和提供新的方法论 用于现场研究的普遍计算；与护理和社会科学家进行定性和比较 有效研究；以及锻炼生理学家和分子生物学家，用于连接的技术 具有动态疾病表型的基因组信息。 3）共享信息 - ICT已参与 信息与计算机科学学院的临床医生，医院IT员工和学者创建 生物医学信息学中心。现在，我们准备嵌入基础架构以进行临床数据互操作性 在一个独特的时刻，即UCI开始部署其EMR。 4）参与我们的社区ICT 倡导了等新方法，例如Peer（参与者的研究中的参与者体验），该计划 这将研究志愿者视为发现过程中的合作伙伴。我们计划一系列 宣传/传播活动，从减轻虐待老年人到预防小儿突然死亡 运动员。 5）火车 - 我们将实施跨越边界，一组学位和证书计划 以及指导互动，解决转化科学中的关键问题。最后，我们看待自己 作为南加州独特转化科学网络的一部分，该地区的资源 学术医疗中心被整合在一起，以更好地实现CTSA的总体愿景。 相关性（请参阅说明）： 在南加州这个动态地区，UCI正在成为临床研究的激励力量。这 ICT将支持各种各样的项目，这些项目将使公共卫生受益，包括雄心勃勃的NIH资助 国家儿童的研究；研究线粒体起源的罕见，研究不足的疾病；和社区 宣传努力，以减轻我们地区保险人不足的人中肥胖的健康后果。

项目成果

Finite Element Model Analysis of Cephalic Trim on Nasal Tip Stability.

• DOI: 10.1001/jamafacial.2015.0941
• 发表时间: 2015-11
• 期刊: JAMA facial plastic surgery
• 作者: Leary RP;Manuel CT;Shamouelian D;Protsenko DE;Wong BJ
• 通讯作者: Wong BJ

A dynamic, embodied paradigm to investigate the role of serotonin in decision-making.

• DOI: 10.3389/fnint.2013.00078
• 发表时间: 2013-11-21
• 期刊: Frontiers in integrative neuroscience
• 影响因子: 3.5
• 作者: Asher DE;Craig AB;Zaldivar A;Brewer AA;Krichmar JL
• 通讯作者: Krichmar JL

Cost comparison of robotic-assisted laparoscopic hysterectomy versus standard laparoscopic hysterectomy.

• DOI: 10.1007/s11701-015-0526-z
• 发表时间: 2015-12
• 期刊: Journal of robotic surgery
• 影响因子: 2.3
• 作者: Winter ML;Leu SY;Lagrew DC Jr;Bustillo G
• 通讯作者: Bustillo G

Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.

• DOI: 10.1159/000360010
• 发表时间: 2014
• 期刊: American journal of nephrology
• 影响因子: 4.2
• 作者: Wong J;Piceno YM;DeSantis TZ;Pahl M;Andersen GL;Vaziri ND
• 通讯作者: Vaziri ND

Altered insulin response to an acute bout of exercise in pediatric obesity.

改变了儿童肥胖患者对急性运动的胰岛素反应。

• DOI: 10.1123/pes.2013-0182
• 发表时间: 2014
• 期刊: Pediatric exercise science
• 影响因子: 1.8
• 作者: Tran,BrianD;Leu,Szu-Yun;Oliver,Stacy;Graf,Scott;Vigil,Diana;Galassetti,Pietro
• 通讯作者: Galassetti,Pietro