Collab and Service

合作与服务

• 批准号: 9114600
• 负责人: Aaron Chang
• 金额: $ 8.71万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9114600
• 关键词: Adoption; Alzheimer' s Disease; Anorexia Nervosa; Area; Autistic Disorder; B cell differentiation; Biological; Biology; Biomedical Research; Cell Communication; Cells; Collaborations; Communities; Country; Custom; DNA Repair; Data; Development; Diabetes Mellitus; Disease; Family; Fostering; Frontotemporal Dementia; Geographic state; Glaucoma; Goals; Heart Diseases; Hereditary Spastic Paraplegia; High Performance Computing; Imagery; Inflammation; Internet; Investments; Journals; Malaria; Methods; Modeling; Nature; Oxidative Stress; Pathway Analysis; Proliferating; Proteomics; Publications; Publishing; Reporting; Research; Research Infrastructure; Resources; Science; Services; Site; Software Tools; Staging; System; Technology; Time; Transcriptional Regulation; Virus Diseases; Work; Wound Healing; base; biological adaptation to stress; cancer stem cell; cancer type; cilium biogenesis; cluster computing; cyber infrastructure; leukemia; member; metabolomics; open source; outreach; pathway tools; stem cell differentiation; technology development; tool

COLLABORATION AND SERVICE - PROJECT SUMMARY The Collaboration and Service component of the National Resource for Network Biology (NRNB) aims to identify collaborations that leverage our technology projects in developing new network methods, and to broaden the application of existing network analysis tools to a wide range of biomedical research domains. Our collaborations range from the use of Cytoscape as a research tool for network analysis and visualization to the development of Cytoscape apps for custom data types and analyses, new Internet-based Cytoscape Cyberinfrastructure components, application of other network and pathways tools and resources for network biology, and to users of NRNB's high performance computing cluster. Using these tools, we have fostered numerous discoveries in a variety of disease areas, such as hereditary spastic paraplegia, frontal temporal dementia, Alzheimer's disease, diabetes, anorexia nervosa, glaucoma, heart disease, leukemia, autism, malaria, and many types of cancer. Our tools and methods are also being applied in collaborative studies of the mechanisms underlying inflammation, stem cell differentiation, B-cell differentiation, ciliogenesis, cell-cell communication, transcriptional regulation, oxidative stress responses, DNA repair, cancer stem cells, viral infection, and wound healing, as well as general interactome, proteomics, and metabolomics research. Beyond our network analysis collaborations, we also engage in collaborations to develop new network biology methods and tools, often to produce free, open source Cytoscape apps, which can then be used by the entire network biology community. The diversity of NRNB collaboration projects can also be characterized as spanning every stage of a 4-stage technology development model: (1) Identifying a problem, biological question and target community, (2) Developing a new method or approach as a solution, and establishing a proof of concept, (3) Implementing a solution as a software tool or technology, and (4) Enabling and achieving broad adoption of the method via your tool or technology. The NRNB maintains staff at each member site to identify, screen and manage collaboration and service projects. In the past 4 years, we have maintained 60-80 active projects at any given time and have established a total of ~150 collaborations. With our broad outreach efforts, NRNB collaborations span 11 US states and 17 countries. As of July 2014, we report 47 publications resulting from NRNB collaboration and service projects. These publications have already been cited over 5,300 times. Notably, 20 of these publications are in Nature, Science and Cell family journals. .

合作与服务 - 项目摘要 国家网络生物学资源 (NRNB) 的协作和服务部分旨在 确定利用我们的技术项目开发新网络方法的合作， 并将现有网络分析工具的应用范围扩大到广泛的生物医学领域 研究领域。我们的合作范围包括使用 Cytoscape 作为网络研究工具 分析和可视化到开发用于自定义数据类型和分析的 Cytoscape 应用程序， 新的基于互联网的Cytoscape网络基础设施组件，其他网络的应用和 网络生物学的途径工具和资源，以及 NRNB 高性能的用户 计算集群。 使用这些工具，我们在各种疾病领域取得了许多发现，例如 遗传性痉挛性截瘫、额颞叶痴呆、阿尔茨海默病、糖尿病、厌食症 神经病、青光眼、心脏病、白血病、自闭症、疟疾和多种癌症。我们的工具 并且方法也被应用于潜在机制的合作研究 炎症、干细胞分化、B 细胞分化、纤毛发生、细胞间通讯、 转录调控、氧化应激反应、DNA修复、癌症干细胞、病毒感染、 和伤口愈合，以及一般相互作用组、蛋白质组和代谢组学研究。超过 我们的网络分析合作，我们还参与开发新的网络生物学的合作 方法和工具，通常用于生成免费的开源 Cytoscape 应用程序，然后供用户使用 整个网络生物学界。 NRNB 合作项目的多样性还可以概括为跨越各个阶段 4阶段技术开发模型：（1）确定问题、生物学问题和目标 社区，(2) 开发一种新的方法或途径作为解决方案，并建立证明 概念，(3) 将解决方案实施为软件工具或技术，以及 (4) 启用和实现 通过您的工具或技术广泛采用该方法。 NRNB 在每个成员站点都有工作人员来识别、筛选和管理协作以及 服务项目。在过去 4 年里，我们在任何特定时间都维持着 60-80 个活跃项目，并且 总共建立了约150个合作。通过我们广泛的外展努力，NRNB 合作 横跨美国 11 个州和 17 个国家。截至 2014 年 7 月，我们报告了 NRNB 发表的 47 篇出版物 合作和服务项目。这些出版物已被引用超过 5,300 次。 值得注意的是，其中 20 篇出版物发表在《自然》、《科学》和《细胞》家族期刊上。 。