Hand proprioception and sensorimotor interplay

手本体感觉和感觉运动相互作用

• 批准号: 9035440
• 负责人: SLIMAN BENSMAIA
• 金额: $ 35.96万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9035440
• 关键词: Activities of Daily Living; Address; Animals; Area; Attention; Behavior; Brain; Communication; Complex; Conscious; Development; Electric Stimulation; Electrodes; Ensure; Feedback; Fingers; Goals; Hand; Health; Human; Implant; Individual; Joints; Lesion; Limb Prosthesis; Limb structure; Link; Measures; Mechanics; Methods; Modality; Molecular Conformation; Monitor; Monkeys; Motion; Motor; Motor Cortex; Movement; Muscle; Neurons; Organ; Pattern; Play; Population; Positioning Attribute; Posture; Primates; Process; Property; Proprioception; Prosthesis; Research; Role; Sampling; Sensory; Shapes; Shoes; Signal Transduction; Skin; Somatosensory Cortex; System; Techniques; Technology; Touch sensation; Training; Unconscious State; Upper Extremity; Vision; Work; base; body position; density; finger movement; grasp; interest; kinematics; mathematical methods; motor control; multi-electrode arrays; neuroprosthesis; nonhuman primate; receptive field; receptor; relating to nervous system; response; sensory feedback; sensory input; somatosensory; tool

DESCRIPTION (provided by applicant): The hand is one of the most complex, versatile, and critical human sensory organs. Sensory signals from the hand play a key role in guiding the dexterous manipulation of objects. Without these signals, we would need to constantly watch our hand to ensure that an object was properly grasped, to monitor our use of a tool, and to maintain its proper shape. Furthermore, simple activities of daily living, such as tying one's shoe, or turning a door knob, would be slow and clumsy, and require great concentration. In contrast to the sense of touch, which has received a lot of experimental attention, the representation of hand position and hand movements in the brain is poorly understood. Indeed, unlike vision and audition, for which monitors and speakers are commercially available, proprioception research presents unique technological challenges in measuring and manipulating the sensory input. As increasingly sophisticated technologies become available, however, we are able to more fruitfully investigate this important sensory modality. Our objective is to apply rigorous and quantitative methods to investigate the cortical basis of proprioception in primates, with an emphasis on hand kinematics and posture. Furthermore, we seek to understand how proprioceptive representations interact with motor representations in the cortex to guide behavior. To these ends, monkeys will perform two tasks: a grasping task, with objects different widely in shape and size, and a finger-press task, in which the animal is instructed to make individuated finger movements. While the monkeys perform these tasks, we will measure their hand movements using a camera- based motion tracking system, and record, using chronically implanted high-density multi-electrode arrays, the neuronal activity evoked in proprioceptive and motor areas of the cortex. We will then use a variety of mathematical techniques to (1) understand how hand movements and position are represented in the activity of individual neurons and of neuronal populations and (2) characterize the interactions between proprioceptive and motor representations to understand the role of this sensorimotor interplay in motor control. Our labs are currently developing approaches to convey sensory feedback through electrical stimulation of cortex for use in upper-limb neuroprostheses. Proprioceptive information about the position and movements of the prosthetic limb is essential for a complete prosthetic limb for the same reasons it is important in the native limb. Results from the proposed project will thus inform how to incorporate proprioceptive feedback in sensorized neuroprostheses.

描述（由申请人提供）：手是最复杂，最广泛和关键的人类感觉器官之一。手中的感官信号在指导物体的灵巧操纵方面起着关键作用。没有这些信号，我们将需要不断地注视着我们的手，以确保对象正确掌握，以监视我们对工具的使用并保持其正确的形状。此外，日常生活的简单活动，例如绑在鞋子或旋转门旋钮的情况下会很慢而笨拙，并且需要大量的集中注意力。与吸引了很多实验性关注的触觉相反，大脑中的手位置和手动运动的表现知之甚少。实际上，与视觉和试听不同，在商业上可以进行监视和说话者，本体感受研究提出了在衡量和操纵感官输入方面面临的独特技术挑战。但是，随着越来越复杂的技术可用，我们能够更加有效地研究这种重要的感觉方式。 我们的目标是应用严格和定量的方法来研究灵长类动物本体感受的皮质基础，重点是手动运动和姿势。此外，我们试图了解本体感受的表示如何与皮层中的运动表示形式相互作用以指导行为。在这些末端，猴子将执行两个任务：抓紧任务，形状和大小的物体差异很大，指手指压力任务，其中指示动物进行个性化的手指运动。当猴子执行这些任务时，我们将使用基于摄像机的运动跟踪系统来测量他们的手运动，并使用长期植入的高密度多电极阵列记录，在皮质的前置和运动区域引起的神经元活动。然后，我们将使用各种数学技术来（1）了解在单个神经元和神经元种群活动中的手势和位置如何表示，并且（2）（2）表征了本体感受和运动表示之间的相互作用，以了解该感觉运动相互作用在运动控制中的作用。 我们的实验室目前正在开发通过在上limb神经phopthes中使用皮质的电刺激来传达感觉反馈的方法。有关假体肢体的位置和运动的本体感知信息对于一个完全的假肢至关重要，因为它在本地肢体中很重要。因此，拟议项目的结果将告知如何将本体感受反馈纳入传感器神经phip。