Reward responsivity and depression in autism spectrum disorder: A multimethod approach

自闭症谱系障碍中的奖励反应和抑郁：多种方法

基本信息

批准号：
10571567
负责人：
Jessica M Schwartzman
金额：
$ 16.04万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-12-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10571567
关键词：
17 year old Adolescence Adolescent Adult Behavioral Biological Markers Clinical Complex Development Development Plans Developmental Course Diagnostic Early Diagnosis Early Intervention Electroencephalography Employment Event-Related Potentials Face Family member Future Goals High Prevalence Impairment Intervention Interview Investigation Knowledge Literature Maintenance Measurement Measures Mental Depression Mental disorders Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methodology Methods Modeling Mood Disorders National Institute of Mental Health Neurobiology Outcome Pathway interactions Population Positive Valence Prevalence Provider Psychophysiology Quality of life Research Research Domain Criteria Rewards Risk Risk Factors Sampling Schedule Schizophrenia Schools Severities Social Interaction Social Processes Strategic Planning Symptoms Techniques Testing Time Training Translating Translational Research Vulnerable Populations Work adolescent with autism spectrum disorder autism spectrum disorder career career development child depression clinical translation depressive symptoms emotional experience experience follow-up high risk longitudinal analysis longitudinal design method development mortality risk neural neurophysiology novel peer physical conditioning premature prospective recruit response screening social social communication suicidal morbidity symptomatology therapy development

项目摘要

PROJECT SUMMARY Adolescents with Autism Spectrum Disorder experience depression at rates nearly twice that of their neurotypical peers (20% vs. 11%). Untreated depression is associated with adverse short (e.g., school refusal) and long-term outcomes (e.g., poor physical health, lower employment) that impair quality of life. Adolescents with autism also face a 10x increase in the risk for premature death by suicide than their neurotypical peers. Risk factors to depression in autism are not well understood and measurement efforts may be complicated by social communication difficulties (i.e., autism symptomatology) that complicate adolescents’ efforts to identify and explain emotional experiences to providers and family members. Therefore, more objective measures (e.g., electroencephalogram [EEG], specifically event-related potentials [ERPs]) may provide a better understanding of risk factors to depression in adolescents with autism. Altered reward responsivity (Research Domain Criteria [RDoC] Positive Valence) and disrupted social processes (RDoC Affiliation and Attachment) are key risk factors to depression for neurotypical adolescents, but have not been investigated in autism. Clinical and neural measures of social and nonsocial reward responsivity and associations with depression symptoms have not been examined in autism, which may provide meaningful information about developmental trajectories. Consistent with the NIMH Strategic Plan, Strategic Goal 2, “to identify and understand risk factors, biomarkers and behavioral indicators of mental illness,” this K23 application aims to examine clinical and neural markers of social and nonsocial reward responsivity and associations with depression symptoms in adolescents with autism, including longitudinal investigations. Under the mentorship of a diverse team of experts in autism, depression, reward responsivity, psychophysiological methods, and longitudinal and statistical methodologies, this proposal will examine the predictive influences of these RDoC constructs to depression in adolescents 14-17 years old with autism. Adolescence is a key developmental period for early detection and intervention as it is characterized by spikes in depression prevalence and an increasing importance of peer relationships. Specifically, this proposal will use EEG/ERP techniques and clinician-rated interviews to measure social and nonsocial reward responsivity in adolescents with autism and test relationships with depression symptoms. Adolescents will be assessed one year later to investigate how clinical and neural measures predict depression symptoms over time, which will inform the developmental course of these RDoC constructs in this vulnerable population. The applicant’s long- term goal is to understand the neurobiological and behavioral development of reward responsivity in autism and associations with depression from adolescence to adulthood so as to inform screening methods and intervention development. Mentored training will allow the applicant to gain expertise in multimethod measures (e.g., ERP methodologies, clinician-rated interviews) and longitudinal design and analysis, with an emphasis on assessing mechanisms associated with the onset, maintenance, and treatment of depression in autism.

项目概要患有自闭症谱系障碍的青少年患抑郁症的几率几乎是正常青少年的两倍未治疗的抑郁症与短期（例如拒绝上学）和长期不良行为有关。影响自闭症青少年生活质量的结果（例如身体健康状况不佳、就业率下降）。与神经正常同龄人相比，自杀过早死亡的风险增加 10 倍。自闭症中的抑郁症尚未得到很好的理解，测量工作可能会因社会原因而变得复杂沟通困难（即自闭症症状）使青少年难以识别和理解向提供者和家庭成员解释情感经历因此，需要采取更客观的措施（例如，脑电图 [EEG]，特别是事件相关电位 [ERP]）可以提供更好的理解自闭症青少年抑郁的危险因素改变的奖励反应（研究领域标准） [RDoC] 正价）和扰乱的社会过程（RDoC 归属和依恋）是关键风险因素神经典型青少年的抑郁症，但尚未对自闭症进行研究。临床和神经社会和非社会奖励反应的测量以及与抑郁症状的关联尚未在自闭症中进行了检查，这可能提供有关发展轨迹的有意义的信息。与 NIMH 战略计划的战略目标 2 一致，“识别和了解风险因素、生物标志物和精神疾病的行为指标”，这个 K23 应用程序旨在检查精神疾病的临床和神经标记自闭症青少年的社会和社会非奖励反应以及与抑郁症状的关联，包括在自闭症、抑郁症等领域的多元化专家团队的指导下进行纵向调查。奖励反应、心理生理学方法以及纵向和统计方法，该提案将检查这些 RDoC 结构对 14-17 岁青少年抑郁症的预测影响自闭症的特点是青春期是早期发现和干预的关键发育时期。具体来说，该提案是通过抑郁症患病率的激增和同伴关系的日益重要性来实现的。将使用 EEG/ERP 技术和临床医生评定的访谈来衡量社会和非社会奖励反应在患有自闭症的青少年中，将评估与抑郁症状的青少年的关系。一年后研究临床和神经测量如何随着时间的推移预测抑郁症状，这将告知这些 RDoC 结构在该弱势群体中的发展过程。术语目标是了解自闭症和奖励反应的神经生物学和行为发展从青春期到成年期与抑郁症的关联，以便为筛查方法和干预提供信息指导培训将使申请人获得多方法措施（例如 ERP）方面的专业知识。方法论、临床医生评级访谈）以及纵向设计和分析，重点是评估与自闭症抑郁症的发生、维持和治疗相关的机制。