A personal exposure and response monitoring system for pediatric asthma study

用于小儿哮喘研究的个人暴露和反应监测系统

• 批准号: 9076677
• 负责人: NONGJIAN TAO
• 金额: $ 195.55万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9076677
• 关键词: Acute; Address; Air; Algorithms; Arizona; Asthma; Breathing; California; Cellular Phone; Charge; Chemicals; Child; Childhood Asthma; Cloud Computing; Collaborations; Communication; Communication Aids for Disabled; Communities; Data; Data Analyses; Data Collection; Detection; Development; Devices; Environment; Environmental Exposure; Environmental Health; Epidemiologic Studies; Epidemiologist; Epidemiology; Equipment; Exposure to; Formaldehyde; Future; Goals; Gold; Health; Heart Rate; Hospitals; Hour; Humidity; Industry Collaborators; Location; Methods; Monitor; Nitrogen Dioxide; Ozone; Particle Size; Particulate Matter; Pattern; Pediatric Research; Performance; Physical activity; Physiological; Pilot Projects; Pollution; Population Study; Prevention; Production; Reference Standards; Resolution; Signal Transduction; Symptoms; System; Techniques; Technology; Temperature; Testing; Time; Universities; Validation; Wireless Technology; Work; air sampling; commercialization; data management; design; detector; digital; industry partner; miniaturize; novel; public health relevance; response; sensor; signal processing; tool; transmission process; usability

 DESCRIPTION (provided by applicant): This project will focus on creating a button-sized wearable sensor for monitoring personal exposure to both chemicals and particulate matter. This unprecedented capability will pair with physiological signal monitors to provide both environmental exposure and physiological response data. The data communication of the device will be designed such that it can be plugged into a smartphone or cloud computing data management system for easy access and analysis of the data by epidemiologists. Such a system will have an impact on the epidemiological study of the pollution exposure-response relationship, and eventually the prevention of pediatric asthma. The project will provide a wearable exposure sensor to address the challenges proposed by RFA-EB-15-002, Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS): Sensor Development Projects for Asthma (U01). The sensor will be designed to pair with other physiological signal monitors, and plug into other data management system developed by PRISMS. The specific objectives of the project are to: 1) Develop a button-sized sensor that can monitor indoor and outdoor exposure of a child 24 hours a day. The initial target analytes include important potential asthma triggers, such as particulate matter, nitrogen dioxide, ozone, and formaldehyde, as well as temperature and humidity, but the sensor platform is expandable to allow inclusion of more analytes in the future. The sensor also includes an accelerometer chip to track whether the subjects actually wear the sensor as intended. 2) Pair the button-sized personal exposure sensor with physiological signal monitors, and develops seamless data communication with an Asthma Study App, and 3) validate the entire system via a small-scale pilot study. The project will bring together strengths in chemical sensors, particulate matter detectors, epidemiology, and digital health from different groups. In order to create a long lastin impact and benefit for the large environmental health study community and end users, the team will also work with industry collaborators to prepare for commercialization.

 描述（由申请人提供）：该项目将重点放在纽扣尺寸的LS和颗粒上。智能手机或云计算的数据管理，可轻松访问该系统的数据。暴露传感器应对使用集成传感器监测系统（PRISM）的RFA-EB-15-002提出的挑战：哮喘的传感器开发项目（U01）。为：1）开发一个按钮大小的传感器，该传感器可以监视一天的室内和室外曝光。可以扩展，以便将来包含更多的分析物。 ，3）通过小型试点研究，流行病学和数字健康，从而为他们的大型环境健康研究社区和最终用户验证了整个系统。 Willy与事业合作者合作的工作，为商业化做准备。